GPX2 (gene)

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Protein GPX2 PDB 2he3.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesGPX2, GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPX-GI, GSHPx-2, glutathione peroxidase 2
External IDsOMIM: 138319 MGI: 106609 HomoloGene: 20479 GeneCards: GPX2
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for GPX2
Genomic location for GPX2
Band14q23.3Start64,939,152 bp[1]
End64,942,905 bp[1]
RNA expression pattern
PBB GE GPX2 202831 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 14: 64.94 – 64.94 MbChr 12: 76.79 – 76.8 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Glutathione peroxidase 2 is an enzyme that in humans is encoded by the GPX2 gene.[5][6][7]

This gene is a member of the glutathione peroxidase family encoding a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. Studies in knockout mice indicate that mRNA expression levels respond to luminal microflora, suggesting a role of the ileal glutathione peroxidases in preventing inflammation in the GI tract.[7]

The antioxidant enzyme glutathione peroxidase 2 (Gpx2) is one out of eight known glutathione peroxidases (Gpx1-8) in humans. Mammalian Gpx1, GPx2 (this protein), Gpx3, and Gpx4 have been shown to be selenium-containing enzymes, whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents. In selenoproteins, the 21st amino acid selenocysteine is inserted in the nascent polypeptide chain during the process of translational recoding of the UGA stop codon.


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176153 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042808 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chu FF, Doroshow JH, Esworthy RS (Mar 1993). "Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI". J Biol Chem. 268 (4): 2571–6. PMID 8428933.
  6. ^ Chu FF (Feb 1994). "The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively". Cytogenet Cell Genet. 66 (2): 96–8. doi:10.1159/000133675. PMID 8287691.
  7. ^ a b "Entrez Gene: GPX2 glutathione peroxidase 2 (gastrointestinal)".

Further reading[edit]