GPX2 (gene)

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Protein GPX2 PDB 2he3.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases GPX2, GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPX-GI, GSHPx-2, glutathione peroxidase 2
External IDs MGI: 106609 HomoloGene: 20479 GeneCards: 2877
RNA expression pattern
PBB GE GPX2 202831 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 14: 64.94 – 64.94 Mb Chr 12: 76.79 – 76.8 Mb
PubMed search [1] [2]
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Glutathione peroxidase 2 is an enzyme that in humans is encoded by the GPX2 gene.[3][4][5]

This gene is a member of the glutathione peroxidase family encoding a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. Studies in knockout mice indicate that mRNA expression levels respond to luminal microflora, suggesting a role of the ileal glutathione peroxidases in preventing inflammation in the GI tract.[5]

The antioxidant enzyme glutathione peroxidase 2 (Gpx2) is one out of eight known glutathione peroxidases (Gpx1-8) in humans. Mammalian Gpx1, GPx2 (this protein), Gpx3, and Gpx4 have been shown to be selenium-containing enzymes, whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents. In selenoproteins, the 21st amino acid selenocysteine is inserted in the nascent polypeptide chain during the process of translational recoding of the UGA stop codon.


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Chu FF, Doroshow JH, Esworthy RS (Mar 1993). "Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI". J Biol Chem. 268 (4): 2571–6. PMID 8428933. 
  4. ^ Chu FF (Feb 1994). "The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively". Cytogenet Cell Genet. 66 (2): 96–8. doi:10.1159/000133675. PMID 8287691. 
  5. ^ a b "Entrez Gene: GPX2 glutathione peroxidase 2 (gastrointestinal)". 

Further reading[edit]