GPX2 (gene)

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Glutathione peroxidase 2
Protein GPX2 PDB 2he3.png
PDB rendering based on 2he3.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GPX2 ; GI-GPx; GPRP; GPRP-2; GPx-2; GPx-GI; GSHPX-GI; GSHPx-2
External IDs OMIM138319 MGI106609 HomoloGene20479 GeneCards: GPX2 Gene
EC number
RNA expression pattern
PBB GE GPX2 202831 at tn.png
More reference expression data
Species Human Mouse
Entrez 2877 14776
Ensembl ENSG00000176153 ENSMUSG00000042808
UniProt P18283 Q9JHC0
RefSeq (mRNA) NM_002083 NM_030677
RefSeq (protein) NP_002074 NP_109602
Location (UCSC) Chr 14:
64.94 – 64.94 Mb
Chr 12:
76.79 – 76.8 Mb
PubMed search [1] [2]

Glutathione peroxidase 2 is an enzyme that in humans is encoded by the GPX2 gene.[1][2][3]

This gene is a member of the glutathione peroxidase family encoding a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. Studies in knockout mice indicate that mRNA expression levels respond to luminal microflora, suggesting a role of the ileal glutathione peroxidases in preventing inflammation in the GI tract.[3]

The antioxidant enzyme glutathione peroxidase 2 (Gpx2) is one out of eight known glutathione peroxidases (Gpx1-8) in humans. Mammalian Gpx1, GPx2 (this protein), Gpx3, and Gpx4 have been shown to be selenium-containing enzymes, whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents. In selenoproteins, the 21st amino acid selenocysteine is inserted in the nascent polypeptide chain during the process of translational recoding of the UGA stop codon.


  1. ^ Chu FF, Doroshow JH, Esworthy RS (Mar 1993). "Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI". J Biol Chem 268 (4): 2571–6. PMID 8428933. 
  2. ^ Chu FF (Feb 1994). "The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively". Cytogenet Cell Genet 66 (2): 96–8. doi:10.1159/000133675. PMID 8287691. 
  3. ^ a b "Entrez Gene: GPX2 glutathione peroxidase 2 (gastrointestinal)". 

Further reading[edit]