GPX3

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GPX3
PDB 2r37 EBI.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGPX3, GPx-P, GSHPx-3, GSHPx-P, glutathione peroxidase 3
External IDsMGI: 105102 HomoloGene: 20480 GeneCards: GPX3
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for GPX3
Genomic location for GPX3
Band5q33.1Start151,020,438 bp[1]
End151,028,992 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002084
NM_001329790

NM_001083929
NM_008161
NM_001329860

RefSeq (protein)

NP_001316719
NP_002075

NP_001316789
NP_032187

Location (UCSC)Chr 5: 151.02 – 151.03 MbChr 11: 54.9 – 54.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an enzyme that in humans is encoded by the GPX3 gene.[5][6][7]

GPx-3 belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000211445 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018339 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: glutathione peroxidase 3 (plasma)".
  6. ^ Takahashi K, Avissar N, Whitin J, Cohen H (August 1987). "Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme". Arch. Biochem. Biophys. 256 (2): 677–86. doi:10.1016/0003-9861(87)90624-2. PMID 3619451.
  7. ^ Chu FF (1994). "The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively". Cytogenet. Cell Genet. 66 (2): 96–8. doi:10.1159/000133675. PMID 8287691.

Further reading[edit]