From Wikipedia, the free encyclopedia
Jump to: navigation, search
Glutathione peroxidase 3
PDB 2r37 EBI.png
PDB rendering based on 2r37.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GPX3 ; GPx-P; GSHPx-3; GSHPx-P
External IDs OMIM138321 MGI105102 HomoloGene20480 GeneCards: GPX3 Gene
EC number
Species Human Mouse
Entrez 2878 14778
Ensembl ENSG00000211445 ENSMUSG00000018339
UniProt P22352 P46412
RefSeq (mRNA) NM_002084 NM_001083929
RefSeq (protein) NP_002075 NP_032187
Location (UCSC) Chr 5:
151.02 – 151.03 Mb
Chr 11:
54.9 – 54.91 Mb
PubMed search [1] [2]

Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an enzyme that in humans is encoded by the GPX3 gene.[1][2][3]

GPx-3belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.[1]


  1. ^ a b "Entrez Gene: glutathione peroxidase 3 (plasma)". 
  2. ^ Takahashi K, Avissar N, Whitin J, Cohen H (August 1987). "Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme". Arch. Biochem. Biophys. 256 (2): 677–86. doi:10.1016/0003-9861(87)90624-2. PMID 3619451. 
  3. ^ Chu FF (1994). "The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively". Cytogenet. Cell Genet. 66 (2): 96–8. doi:10.1159/000133675. PMID 8287691. 

Further reading[edit]