GPX5

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GPX5
PDB 2i3y EBI.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GPX5, HEL-S-75p, glutathione peroxidase 5
External IDs MGI: 104886 HomoloGene: 1155 GeneCards: 2880
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001509
NM_003996

NM_010343

RefSeq (protein)

NP_001500.1
NP_003987.2

NP_034473.2

Location (UCSC) Chr 6: 28.53 – 28.53 Mb Chr 13: 21.29 – 21.29 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene.[3][4]

GPx-5 belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[3]

References[edit]

Further reading[edit]