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Glutathione peroxidase 5
PDB 2i3y EBI.png
PDB rendering based on 2i3y.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GPX5 ; HEL-S-75p
External IDs OMIM603435 MGI104886 HomoloGene1155 GeneCards: GPX5 Gene
EC number
Species Human Mouse
Entrez 2880 14780
Ensembl ENSG00000224586 ENSMUSG00000004344
UniProt O75715 P21765
RefSeq (mRNA) NM_001509 NM_010343
RefSeq (protein) NP_001500 NP_034473
Location (UCSC) Chr 6:
28.53 – 28.53 Mb
Chr 13:
21.29 – 21.29 Mb
PubMed search [1] [2]

Glutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene.[1][2]

GPx-5 belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[1]


Further reading[edit]