GRAM domain

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
GRAM domain
1zvr.png
Myotubularin-related protein 2
Identifiers
SymbolGRAM
PfamPF02893
Pfam clanCL0266
InterProIPR004182
SMARTGRAM
SCOP1lw3
SUPERFAMILY1lw3
OPM superfamily130
OPM protein1zvr
CDDcd10570
Membranome349

The GRAM domain is found in glucosyltransferases, myotubularins and other membrane-associated proteins.[1] The structure of the GRAM domain is similar to that found in PH domains.[2]

Human proteins containing this domain[edit]

DIP; GRAMD1A; GRAMD1B; GRAMD1C; GRAMD2; GRAMD3; MTM1; MTMR1; MTMR2; NCOA7; NSMAF; OXR1; SBF1; SBF2; TBC1D8; TBC1D8B; TBC1D9; TBC1D9B; WBP2; WBP2NL; dJ439F8.1;

References[edit]

  1. ^ Doerks T, Strauss M, Brendel M, Bork P (October 2000). "GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins". Trends Biochem. Sci. 25 (10): 483–5. doi:10.1016/S0968-0004(00)01664-9. PMID 11050430.
  2. ^ Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA (December 2003). "Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome". Mol. Cell. 12 (6): 1391–402. doi:10.1016/S1097-2765(03)00486-6. PMID 14690594.