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Protein GRAP2 PDB 1h3h.png
Aliases GRAP2, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38, GRB2-related adaptor protein 2, GRB2 related adaptor protein 2
External IDs MGI: 1333842 HomoloGene: 21007 GeneCards: GRAP2
Gene location (Human)
Chromosome 22 (human)
Chr. Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for GRAP2
Genomic location for GRAP2
Band 22q13.1 Start 39,901,082 bp[1]
End 39,973,721 bp[1]
RNA expression pattern
PBB GE GRAP2 208406 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 22: 39.9 – 39.97 Mb Chr 15: 80.62 – 80.65 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2 gene.[5][6][7]


This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.[7]


GRAP2 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100351 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042351 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Qiu M, Hua S, Agrawal M, Li G, Cai J, Chan E, Zhou H, Luo Y, Liu M (Dec 1998). "Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1". Biochemical and Biophysical Research Communications. 253 (2): 443–7. doi:10.1006/bbrc.1998.9795. PMID 9878555. 
  6. ^ a b c d Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K (May 1999). "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT". The Journal of Experimental Medicine. 189 (9): 1383–90. doi:10.1084/jem.189.9.1383. PMC 2193052Freely accessible. PMID 10224278. 
  7. ^ a b "Entrez Gene: GRAP2 GRB2-related adaptor protein 2". 
  8. ^ Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Jul 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". The Journal of Biological Chemistry. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. PMID 10801854. 
  9. ^ a b Ellis JH, Ashman C, Burden MN, Kilpatrick KE, Morse MA, Hamblin PA (Jun 2000). "GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28". Journal of Immunology. 164 (11): 5805–14. doi:10.4049/jimmunol.164.11.5805. PMID 10820259. 
  10. ^ a b Liu SK, Fang N, Koretzky GA, McGlade CJ (Jan 1999). "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors". Current Biology. 9 (2): 67–75. doi:10.1016/s0960-9822(99)80017-7. PMID 10021361. 
  11. ^ a b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  12. ^ Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M (Mar 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene. 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. PMID 11313918. 

Further reading[edit]