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Protein GRB14 PDB 2aug.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesGRB14, growth factor receptor bound protein 14
External IDsMGI: 1355324 HomoloGene: 3303 GeneCards: GRB14
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for GRB14
Genomic location for GRB14
Band2q24.3Start164,492,812 bp[1]
End164,621,848 bp[1]
RNA expression pattern
PBB GE GRB14 206204 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 164.49 – 164.62 MbChr 2: 64.91 – 65.02 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.[5][6]

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.[6]


GRB14 has been shown to interact with Epidermal growth factor receptor,[7] Fibroblast growth factor receptor 1[8] and TNKS2.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115290 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026888 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Baker E, Sutherland GR, Sutherland RL, Daly RJ (February 1997). "Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization". Genomics. 36 (1): 218–220. doi:10.1006/geno.1996.0453. PMID 8812444.
  6. ^ a b "Entrez Gene: GRB14 growth factor receptor-bound protein 14".
  7. ^ Daly, R J; Sanderson G M; Janes P W; Sutherland R L (May 1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. UNITED STATES. 271 (21): 12502–12510. doi:10.1074/jbc.271.21.12502. ISSN 0021-9258. PMID 8647858.
  8. ^ Reilly, J F; Mickey G; Maher P A (March 2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. UNITED STATES. 275 (11): 7771–7778. doi:10.1074/jbc.275.11.7771. ISSN 0021-9258. PMID 10713090.
  9. ^ Lyons, R J; Deane R; Lynch D K; Ye Z S; Sanderson G M; Eyre H J; Sutherland G R; Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. United States. 276 (20): 17172–17180. doi:10.1074/jbc.M009756200. ISSN 0021-9258. PMID 11278563.

Further reading[edit]