GRK4

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GRK4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGRK4, GPRK2L, GPRK4, GRK4a, IT11, G protein-coupled receptor kinase 4
External IDsMGI: 95801 HomoloGene: 23158 GeneCards: GRK4
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for GRK4
Genomic location for GRK4
Band4p16.3Start2,963,608 bp[1]
End3,040,747 bp[1]
RNA expression pattern
PBB GE GRK4 208365 s at fs.png

PBB GE GRK4 210600 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001004056
NM_001004057
NM_005307
NM_182982
NM_001350173

NM_001080743
NM_019497

RefSeq (protein)

NP_001004056
NP_001004057
NP_005298
NP_892027
NP_001337102

NP_001074212
NP_062370

Location (UCSC)Chr 4: 2.96 – 3.04 MbChr 5: 34.66 – 34.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G protein-coupled receptor kinase 4 is an enzyme that in humans is encoded by the GRK4 gene.[5][6]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125388 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052783 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Ambrose C, James M, Barnes G, Lin C, Bates G, Altherr M, Duyao M, Groot N, Church D, Wasmuth JJ, et al. (Jun 1993). "A novel G protein-coupled receptor kinase gene cloned from 4p16.3". Hum Mol Genet. 1 (9): 697–703. doi:10.1093/hmg/1.9.697. PMID 1338872.
  6. ^ a b "Entrez Gene: GRK4 G protein-coupled receptor kinase 4".

Further reading[edit]