GRK4

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GRK4
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GRK4, GPRK2L, GPRK4, GRK4a, IT11, G protein-coupled receptor kinase 4
External IDs MGI: 95801 HomoloGene: 23158 GeneCards: 2868
RNA expression pattern
PBB GE GRK4 208365 s at tn.png

PBB GE GRK4 210600 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001004056
NM_001004057
NM_005307
NM_182982

NM_001080743
NM_019497

RefSeq (protein)

NP_001004056.1
NP_001004057.1
NP_005298.2
NP_892027.2

NP_001074212.1
NP_062370.2

Location (UCSC) Chr 4: 2.96 – 3.04 Mb Chr 5: 34.66 – 34.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

G protein-coupled receptor kinase 4 is an enzyme that in humans is encoded by the GRK4 gene.[1][2]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.[2]

References[edit]

  1. ^ Ambrose C, James M, Barnes G, Lin C, Bates G, Altherr M, Duyao M, Groot N, Church D, Wasmuth JJ, et al. (Jun 1993). "A novel G protein-coupled receptor kinase gene cloned from 4p16.3". Hum Mol Genet 1 (9): 697–703. doi:10.1093/hmg/1.9.697. PMID 1338872. 
  2. ^ a b "Entrez Gene: GRK4 G protein-coupled receptor kinase 4". 

Further reading[edit]