GSK1702934A

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GSK1702934A
GSK1702934A structure.png
Identifiers
  • 3-[1-(5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carbonyl)piperidin-4-yl]-1H-benzimidazol-2-one
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC22H25N3O2S
Molar mass395.52 g·mol−1
3D model (JSmol)
  • C1CCC2=C(CC1)SC(=C2)C(=O)N3CCC(CC3)N4C5=CC=CC=C5NC4=O
  • InChI=1S/C22H25N3O2S/c26-21(20-14-15-6-2-1-3-9-19(15)28-20)24-12-10-16(11-13-24)25-18-8-5-4-7-17(18)23-22(25)27/h4-5,7-8,14,16H,1-3,6,9-13H2,(H,23,27)
  • Key:AXWRAIIIBRLXBP-UHFFFAOYSA-N

GSK1702934A is a chemical compound which acts as an activator of the TRPC family of calcium channels, with selectivity for the TRPC3 and TRPC6 subtypes. It has been used to investigate the role of TRPC channels in heart function and regulation of blood pressure, as well as roles in the brain.[1][2][3][4]

References[edit]

  1. ^ Xu X, Lozinskaya I, Costell M, Lin Z, Ball JA, Bernard R, Behm DJ, Marino JP, Schnackenberg (2013). "CG Characterization of Small Molecule TRPC3 and TRPC6 agonist and Antagonists". Biophysical Journal. 104: 454a. doi:10.1016/j.bpj.2012.11.2513.
  2. ^ Doleschal B, Primessnig U, Wölkart G, Wolf S, Schernthaner M, Lichtenegger M, Glasnov TN, Kappe CO, Mayer B, Antoons G, Heinzel F, Poteser M, Groschner K (April 2015). "TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1". Cardiovascular Research. 106 (1): 163–73. doi:10.1093/cvr/cvv022. PMC 4362401. PMID 25631581.
  3. ^ Tiapko O, Groschner K (July 2018). "TRPC3 as a Target of Novel Therapeutic Interventions". Cells. 7 (7). doi:10.3390/cells7070083. PMC 6071100. PMID 30037143.
  4. ^ Wang Y, Liu L, Tao H, Wen L, Qin S (December 2020). "TRPC6 participates in the development of blood pressure variability increase in sino-aortic denervated rats". Heart and Vessels. 35 (12): 1755–1765. doi:10.1007/s00380-020-01682-1. PMID 32844288.