Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene. 
Glycogen synthase kinase 3-alpha
EC 18.104.22.168 is a multifunctional protein serine kinase, homologous to 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including Drosophila glycogen synthase and various transcription factors (e.g., JUN). It also plays a role in the WNT and phosphoinositide 3-kinase (especially PIK3CG) signaling pathways.  
Model organisms [ edit ]
Model organisms have been used in the study of GSK3A function. A conditional knockout mouse line, called Gsk3a tm1a(EUCOMM)Wtsi  was generated as part of the  International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.   
Male and female animals underwent a standardized
phenotypic screen to determine the effects of deletion.  Twenty one tests were carried out on  mutant mice but no significant abnormalities were observed. 
See also [ edit ]
References [ edit ]
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