GSPT2

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GSPT2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GSPT2, ERF3B, GST2, G1 to S phase transition 2
External IDs MGI: 1316727 HomoloGene: 99786 GeneCards: GSPT2
RNA expression pattern
PBB GE GSPT2 205541 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018094

NM_008179

RefSeq (protein)

NP_060564

NP_032205.2
NP_032205

Location (UCSC) Chr X: 51.74 – 51.75 Mb Chr X: 94.64 – 94.64 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B is an enzyme that in humans is encoded by the GSPT2 gene.[3][4]

GSPT2 is closely related to GSPT1 (MIM 139259), a GTP-binding protein that plays an essential role at the G1- to S-phase transition of the cell cycle in yeast and human cells. GSPT1 is a positive regulator of translational accuracy and, in a binary complex with eRF1 (MIM 600285), functions as a polypeptide chain release factor.[supplied by OMIM][4]

Interactions[edit]

GSPT2 has been shown to interact with PABPC1.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hansen LL, Jakobsen CG, Justesen J (Jan 2000). "Assignment of the human peptide chain release factor 3 (GSPT2) to Xp11.23→p11.21 and of the distal marker DXS1039 by radiation hybrid mapping". Cytogenet Cell Genet. 86 (3–4): 250–1. doi:10.1159/000015353. PMID 10575220. 
  4. ^ a b "Entrez Gene: GSPT2 G1 to S phase transition 2". 
  5. ^ Hoshino, S; Imai M; Kobayashi T; Uchida N; Katada T (Jun 1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein". J. Biol. Chem. UNITED STATES. 274 (24): 16677–80. doi:10.1074/jbc.274.24.16677. ISSN 0021-9258. PMID 10358005. 

Further reading[edit]