GSTA3

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GSTA3
Protein GSTA3 PDB 1gsd.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GSTA3, GSTA3-3, GTA3, glutathione S-transferase alpha 3
External IDs MGI: 95856 HomoloGene: 37355 GeneCards: GSTA3
RNA expression pattern
PBB GE GSTA3 222102 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000847

NM_001077353
NM_001288617
NM_010356

RefSeq (protein)

NP_000838

NP_001070821.1
NP_034486.2
NP_001070821
NP_001275546
NP_034486

Location (UCSC) Chr 6: 52.9 – 52.91 Mb Chr 1: 21.24 – 21.27 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione S-transferase A3 is an enzyme that in humans is encoded by the GSTA3 gene.[3][4][5]

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Suzuki T, Johnston PN, Board PG (Mar 1994). "Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes". Genomics. 18 (3): 680–6. doi:10.1016/S0888-7543(05)80373-8. PMID 8307579. 
  4. ^ Board PG (Apr 1998). "Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4". Biochem J. 330 (2): 827–31. PMC 1219212Freely accessible. PMID 9480897. 
  5. ^ a b "Entrez Gene: GSTA3 glutathione S-transferase A3". 

Further reading[edit]