GSTM3

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GSTM3
Protein GSTM3 PDB 3gtu.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GSTM3, GST5, GSTB, GSTM3-3, GTM3, glutathione S-transferase mu 3 (brain)
External IDs MGI: 1309466 HomoloGene: 658 GeneCards: GSTM3
RNA expression pattern
PBB GE GSTM3 202554 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000849

NM_010360

RefSeq (protein)

NP_000840
NP_000840.2

NP_034490.1
NP_034490

Location (UCSC) Chr 1: 109.73 – 109.74 Mb Chr 3: 107.9 – 107.9 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione S-transferase M3 (brain), also known as GSTM3, is an enzyme which in humans is encoded by the GSTM3 gene.[3][4]

Function[edit]

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including some carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins.[3]

References[edit]

Further reading[edit]