GSTO1

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GSTO1
Protein GSTO1 PDB 1eem.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GSTO1, GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, glutathione S-transferase omega 1
External IDs MGI: 1342273 HomoloGene: 37971 GeneCards: GSTO1
EC number 1.20.4.2
RNA expression pattern
PBB GE GSTO1 201470 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004832
NM_001191002
NM_001191003

NM_010362

RefSeq (protein)

NP_001177931
NP_001177932
NP_004823

NP_034492.1
NP_034492

Location (UCSC) Chr 10: 104.24 – 104.27 Mb Chr 19: 47.85 – 47.86 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.[3][4][5]

This gene encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis.[5] This protein has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J (Sep 2000). "Identification, characterization, and crystal structure of the Omega class glutathione transferases". J Biol Chem. 275 (32): 24798–806. doi:10.1074/jbc.M001706200. PMID 10783391. 
  4. ^ Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG (Mar 2003). "Characterization of the human Omega class glutathione transferase genes and associated polymorphisms". Pharmacogenetics. 13 (3): 131–44. doi:10.1097/01.fpc.0000054062.98065.6e. PMID 12618591. 
  5. ^ a b "Entrez Gene: GSTO1 glutathione S-transferase omega 1". 
  6. ^ Whitbread AK, Masoumi A, Tetlow N, Schmuck E, Coggan M, Board PG (2005). "Characterization of the omega class of glutathione transferases". Meth. Enzymol. Methods in Enzymology. 401: 78–99. doi:10.1016/S0076-6879(05)01005-0. ISBN 978-0-12-182806-6. PMID 16399380. 

Further reading[edit]