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Protein GSTT1 PDB 2c3n.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases GSTT1, glutathione S-transferase theta 1
External IDs GeneCards: GSTT1
Gene location (Human)
Chromosome 22 (human)
Chr. Chromosome 22 (human)
Chromosome 22 (human)
Genomic location for GSTT1
Genomic location for GSTT1
Band 22q11.23 Start 24,376,133 bp
End 24,384,680 bp
RNA expression pattern
PBB GE GSTT1 203815 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 22: 24.38 – 24.38 Mb n/a
PubMed search [1] n/a
View/Edit Human

Glutathione S-transferase theta-1 is an enzyme that in humans is encoded by the GSTT1 gene.[2]

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.[3]


  1. ^ "Human PubMed Reference:". 
  2. ^ Webb G, Vaska V, Coggan M, Board P (Jun 1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics. 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495. 
  3. ^ "Entrez Gene: GSTT1 glutathione S-transferase theta 1".