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Protein GTF2F2 PDB 1bby.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesGTF2F2, BTF4, RAP30, TF2F2, TFIIF, general transcription factor IIF subunit 2
External IDsOMIM: 189969 MGI: 1915955 HomoloGene: 37884 GeneCards: GTF2F2
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for GTF2F2
Genomic location for GTF2F2
Band13q14.12-q14.13Start45,120,510 bp[1]
End45,284,893 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 13: 45.12 – 45.28 MbChr 14: 75.9 – 76.01 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

General transcription factor IIF subunit 2 is a protein that in humans is encoded by the GTF2F2 gene.[5][6]


GTF2F2 has been shown to interact with POLR2E[7] and HTATSF1.[8]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188342 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067995 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (May 1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.
  6. ^ "Entrez Gene: GTF2F2 general transcription factor IIF, polypeptide 2, 38kDa".
  7. ^ Wei W, Dorjsuren D, Lin Y, Qin W, Nomura T, Hayashi N, Murakami S (Apr 2001). "Direct interaction between the subunit RAP30 of transcription factor IIF (TFIIF) and RNA polymerase subunit 5, which contributes to the association between TFIIF and RNA polymerase II". J. Biol. Chem. 276 (15): 12266–73. doi:10.1074/jbc.M009634200. PMID 11278533.
  8. ^ Kim JB, Yamaguchi Y, Wada T, Handa H, Sharp PA (Sep 1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins". Mol. Cell. Biol. 19 (9): 5960–8. doi:10.1128/mcb.19.9.5960. PMC 84462. PMID 10454543.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.