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General transcription factor IIIC, polypeptide 1, alpha 220kDa
Symbols GTF3C1 ; TFIIIC; TFIIIC220; TFIIICalpha
External IDs OMIM603246 MGI107887 HomoloGene31040 GeneCards: GTF3C1 Gene
RNA expression pattern
PBB GE GTF3C1 35671 at tn.png
PBB GE GTF3C1 202320 at tn.png
More reference expression data
Species Human Mouse
Entrez 2975 233863
Ensembl ENSG00000077235 ENSMUSG00000032777
UniProt Q12789 Q8K284
RefSeq (mRNA) NM_001286242 NM_207239
RefSeq (protein) NP_001273171 NP_997122
Location (UCSC) Chr 16:
27.46 – 27.55 Mb
Chr 7:
125.64 – 125.71 Mb
PubMed search [1] [2]

General transcription factor 3C polypeptide 1 is a protein that in humans is encoded by the GTF3C1 gene.[1][2][3]


GTF3C1 has been shown to interact with GTF3C4.[4]


  1. ^ Lagna G, Kovelman R, Sukegawa J, Roeder RG (May 1994). "Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC". Mol. Cell. Biol. 14 (5): 3053–64. doi:10.1128/mcb.14.5.3053. PMC 358673. PMID 8164661. 
  2. ^ L'Etoile ND, Fahnestock ML, Shen Y, Aebersold R, Berk AJ (Apr 1994). "Human transcription factor IIIC box B binding subunit". Proc. Natl. Acad. Sci. U.S.A. 91 (5): 1652–6. doi:10.1073/pnas.91.5.1652. PMC 43221. PMID 8127861. 
  3. ^ "Entrez Gene: GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa". 
  4. ^ Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.