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Aliases GUCY1A2, GC-SA2, GUC1A2, guanylate cyclase 1, soluble, alpha 2, guanylate cyclase 1 soluble subunit alpha 2
External IDs MGI: 2660877 HomoloGene: 47953 GeneCards: GUCY1A2
RNA expression pattern
PBB GE GUCY1A2 206927 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 106.67 – 107.02 Mb Chr 9: 3.53 – 3.89 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Guanylate cyclase soluble subunit alpha-2 is an enzyme that in humans is encoded by the GUCY1A2 gene.[3][4]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G (Jan 1992). "Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme". FEBS Lett. 292 (1–2): 217–22. doi:10.1016/0014-5793(91)80871-Y. PMID 1683630. 
  4. ^ "Entrez Gene: GUCY1A2 guanylate cyclase 1, soluble, alpha 2". 

Further reading[edit]

  • Baba H, Suzuki T, Arai H, Emson PC (2004). "Expression of nNOS and soluble guanylate cyclase in schizophrenic brain". NeuroReport. 15 (4): 677–80. doi:10.1097/00001756-200403220-00020. PMID 15094474. 
  • Bellamy TC, Wood J, Garthwaite J (2002). "On the activation of soluble guanylyl cyclase by nitric oxide". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 507–10. doi:10.1073/pnas.012368499. PMC 117590Freely accessible. PMID 11752394. 
  • Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861. 
  • Bamberger AM, Koglin M, Kempfert J, et al. (2001). "Expression and tissue localization of soluble guanylyl cyclase in the human placenta using novel antibodies directed against the alpha(2) subunit". J. Clin. Endocrinol. Metab. 86 (2): 909–12. doi:10.1210/jc.86.2.909. PMID 11158065. 
  • Budworth J, Meillerais S, Charles I, Powell K (1999). "Tissue distribution of the human soluble guanylate cyclases". Biochem. Biophys. Res. Commun. 263 (3): 696–701. doi:10.1006/bbrc.1999.1444. PMID 10512742. 
  • Yu F, Warburton D, Wellington S, Danziger RS (1997). "Assignment of GUCIA2, the gene coding for the alpha 2 subunit of soluble guanylyl cyclase, to position 11q21-q22 on human chromosome 11". Genomics. 33 (2): 334–6. doi:10.1006/geno.1996.0208. PMID 8660992. 
  • Behrends S, Harteneck C, Schultz G, Koesling D (1995). "A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein". J. Biol. Chem. 270 (36): 21109–13. doi:10.1074/jbc.270.36.21109. PMID 7673142.