GZMB

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GZMB
Protein GZMB PDB 1fq3.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases GZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
External IDs HomoloGene: 108184 GeneCards: GZMB
RNA expression pattern
PBB GE GZMB 210164 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004131
NM_001346011

n/a

RefSeq (protein)

NP_001332940
NP_004122

n/a

Location (UCSC) Chr 14: 24.63 – 24.63 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Granzyme B is a serine protease that in humans is encoded by the GZMB gene.[2] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[3]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet. 84 (5): 465–70. PMID 2323780. doi:10.1007/bf00195821. 
  3. ^ "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.010