Gadoteric acid

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Gadoteric acid
Gadoteric acid.png
Systematic (IUPAC) name
gadolinium(+3) cation; 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate
Clinical data
AHFS/ International Drug Names
CAS Registry Number 72573-82-1 YesY
ATC code V08CA02
PubChem CID: 3085828
KEGG D08007 YesY
Chemical data
Formula C16H25GdN4O8
Molecular mass 558.64 g/mol
 N (what is this?)  (verify)

Gadoteric acid (trade names Artirem, Dotarem) is a macrocycle-structured gadolinium-based MRI contrast agent. It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd3+), and is used in form of the meglumine salt.[1] The drug is approved and used in a number of countries worldwide.[2] It is used to assist imaging of blood vessels and of inflamed or diseased tissue where the blood vessels become 'leaky'. It is often used when viewing intracranial lesions with abnormal vascularity or abnormalities in the blood–brain barrier. Its paramagnetic property reduces the T1 relaxation time (and to some extent the T2 and T2* relaxation times) in NMR, which is the source of its clinical utility.


  1. ^ Herborn, C. U.; Honold, E.; Wolf, M.; Kemper, J.; Kinner, S.; Adam, G.; Barkhausen, J. (2007). "Clinical Safety and Diagnostic Value of the Gadolinium Chelate Gadoterate Meglumine (Gd-DOTA)". Investigative Radiology 42 (1): 58–62. doi:10.1097/01.rli.0000248893.01067.e5. PMID 17213750.  edit
  2. ^ Gadoteric Acid