Gadoxetic acid

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Gadoxetic acid
Clinical data
Trade namesEovist
Other namesGadoxetate disodium (USAN US)
AHFS/Drugs.comInternational Drug Names
ATC code
Legal status
Legal status
  • 2-[[2-[bis(2-oxido-2-oxoethyl)amino]-3-(4-ethoxyphenyl)propyl]-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate; gadolinium(+3) cation
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass681.75 g·mol−1
3D model (JSmol)
  • CCOc1ccc(cc1)C[C@@H](CN(CCN(CC(=O)O)CC(=O)[O-])CC(=O)[O-])N(CC(=O)O)CC(=O)[O-].[Gd+3]
  • InChI=1S/C23H33N3O11.Gd/c1-2-37-18-5-3-16(4-6-18)9-17(26(14-22(33)34)15-23(35)36)10-24(11-19(27)28)7-8-25(12-20(29)30)13-21(31)32;/h3-6,17H,2,7-15H2,1H3,(H,27,28)(H,29,30)(H,31,32)(H,33,34)(H,35,36);/q;+3/p-3/t17-;/m0./s1
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Gadoxetic acid is a gadolinium-based MRI contrast agent.[3] Its salt, gadoxetate disodium, is marketed as Primovist in Europe and Eovist in the United States by Bayer HealthCare Pharmaceuticals.[1][4]

Medical uses[edit]

It is used to increase the T1 signal intensity while imaging the liver lesions such as benign cysts, hemangioma, and liver cancer. It is excreted into bile by active secretion.[5]


In those with end-stage renal failure, the clearance rate is only 17% with terminal half-life of 12 times longer than those with normal renal function.[5]


  1. ^ a b "Eovist- gadoxetate disodium injection, solution". DailyMed. National Library of Medicine, National Institutes of Health, U.S. Health & Human Services. Retrieved 21 April 2021.
  2. ^ "Active substance(s): gadoxetic acid disodium" (PDF). List of nationally authorised medicinal products. European Medicines Agency. 14 January 2021.
  3. ^ Koh DM, Ba-Ssalamah A, Brancatelli G, Fananapazir G, Fiel MI, Goshima S, et al. (August 2021). "Consensus report from the 9th International Forum for Liver Magnetic Resonance Imaging: applications of gadoxetic acid-enhanced imaging". European Radiology. 31 (8): 5615–5628. doi:10.1007/s00330-020-07637-4. PMC 8270799. PMID 33523304.
  4. ^ "Eovist - Homepage". Archived from the original on 2009-04-25. Retrieved 2009-03-22.
  5. ^ a b "Clinical pharmacology and biopharmaceutics review" (PDF). Center for drug evaluation and research. Archived from the original (PDF) on 12 May 2021. Retrieved 15 December 2022.