Galanin receptor 3

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Galanin receptor 3
Symbol GALR3
External IDs OMIM603692 MGI1329003 HomoloGene20798 IUPHAR: 245 ChEMBL: 2731 GeneCards: GALR3 Gene
RNA expression pattern
PBB GE GALR3 33579 i at tn.png
More reference expression data
Species Human Mouse
Entrez 8484 14429
Ensembl ENSG00000128310 ENSMUSG00000006378
UniProt O60755 O88853
RefSeq (mRNA) NM_003614 NM_015738
RefSeq (protein) NP_003605 NP_056553
Location (UCSC) Chr 22:
37.82 – 37.83 Mb
Chr 15:
79.03 – 79.04 Mb
PubMed search [1] [2]

Galanin receptor 3 (GAL3) is a G-protein coupled receptor encoded by the GALR3 gene.[1]

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts[1]

See also[edit]


External links[edit]

  • "Galanin Receptors: GAL3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

  • Smith KE, Walker MW, Artymyshyn R et al. (1998). "Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels". J. Biol. Chem. 273 (36): 23321–6. doi:10.1074/jbc.273.36.23321. PMID 9722565. 
  • Kolakowski LF, O'Neill GP, Howard AD et al. (1998). "Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3". J. Neurochem. 71 (6): 2239–51. doi:10.1046/j.1471-4159.1998.71062239.x. PMID 9832121. 
  • Iismaa TP, Fathi Z, Hort YJ et al. (1999). "Structural organization and chromosomal localization of three human galanin receptor genes". Ann. N. Y. Acad. Sci. 863: 56–63. doi:10.1111/j.1749-6632.1998.tb10683.x. PMID 9928159. 
  • Lapsys NM, Furler SM, Henderson NK et al. (1999). "A polymorphism in the human GALR3 galanin receptor gene (GALNR3)". Mol. Cell. Probes 13 (4): 325–7. doi:10.1006/mcpr.1999.0254. PMID 10441207. 
  • Dunham I, Shimizu N, Roe BA et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Berger A, Tuechler C, Almer D et al. (2002). "Elevated expression of galanin receptors in childhood neuroblastic tumors". Neuroendocrinology 75 (2): 130–8. doi:10.1159/000048229. PMID 11867941. 
  • Belfer I, Hipp H, Bollettino A et al. (2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes, Brain and Behavior 6 (5): 473–81. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333. 
  • Runesson J, Sollenberg UE, Jurkowski W et al. (2010). "Determining receptor–ligand interaction of human galanin receptor type 3". Neurochem. Int. 57 (7): 804–811. doi:10.1016/j.neuint.2010.08.018. PMID 20817064. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.