Edwards began her career at Adelaide youth theatre company Energy Connection. From 1986 to 1989 she was Associate Director of the State Theatre Company of South Australia, has been an Artistic Director of the Melbourne Theatre Company and has worked with every other major theatre Australian company, including the Sydney Theatre Company and Opera Australia. Internationally, Edwards directed the 1996 London revival of Jesus Christ Superstar, which opened on Broadway in 2000, and for which she won an Emmy Award for the televised recording of the production. Edwards contributed to the book of the musical Whistle Down the Wind, for which she directed the West End production. She directed Shakespeare's The Merchant of Venice and A Midsummer Night's Dream at the Chichester Festival Theatre in 2003 and 2004 respectively. Edwards has also directed for the Royal Shakespeare Company and Shakespeare Theatre Company (Washington D.C.). She directed the premiere production of The Boy from Oz.
She co-wrote the book and lyrics of the musical Eureka, which premiered in Melbourne in 2004.
Edwards' credits directing for film and television include the 2011 Australian film A Heartbeat Away and the "Pride" segment of 1993 television series Seven Deadly Sins, as well as filmed versions of stage presentations.
Edwards has been the recipient of three Sydney Critics Circle Awards, four Melbourne Green Room Awards (most recently for her 2012 production of Chess for The Production Company), two Mo Awards, an Emmy, two Helpmann Awards (Best Direction of a Musical for The Boy From Oz and Sweeney Todd), a Sydney Critics Award, two nominations for Helen Hayes Awards in Washington D.C., and a 2000 Centenary Medal 'for Service to Australian Society'.
- Schafer, Elizabeth. Ms-directing Shakespeare: women direct Shakespeare.
- Gale Edwards on IMDb
- "2012 Green Room Awards Recipients". Australian Stage Online. 6 May 2013. Retrieved 6 May 2013.
- "2012 Green Room Awards Nominations". Stage Whispers. 18 February 2013. Retrieved 18 February 2013.
- "EDWARDS, Annette Gale". Australian Honours Search Facility, Dept of Prime Minister & Cabinet. Retrieved 9 June 2018.