Gamma-aminobutyric acid receptor subunit alpha-1

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
GABRA1
Identifiers
AliasesGABRA1, ECA4, EIEE19, EJM, EJM5, gamma-aminobutyric acid type A receptor alpha1 subunit
External IDsMGI: 95613 HomoloGene: 629 GeneCards: GABRA1
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for GABRA1
Genomic location for GABRA1
Band5q34Start161,847,063 bp[1]
End161,899,981 bp[1]
RNA expression pattern
PBB GE GABRA1 206678 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010250
NM_001359035

RefSeq (protein)

NP_000797
NP_001121115
NP_001121116
NP_001121117
NP_001121120

NP_034380
NP_001345964

Location (UCSC)Chr 5: 161.85 – 161.9 MbChr 11: 42.13 – 42.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-aminobutyric acid receptor subunit alpha-1 is a protein that in humans is encoded by the GABRA1 gene.[5]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[6]

The GABRA1 receptor is the specific target of the z-drug class of nonbenzodiazepine hypnotic agents and is responsible for their hypnotic and hallucinogenic effects.

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000022355 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000010803 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Johnson KJ, Sander T, Hicks AA, van Marle A, Janz D, Mullan MJ, Riley BP, Darlison MG (Dec 1992). "Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysis". Genomics. 14 (3): 745–8. doi:10.1016/S0888-7543(05)80178-8. PMID 1330891.
  6. ^ "Entrez Gene: GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1".

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.