Ganoderic acid

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Ganoderic acid A
Ganoderic acid.png
Preferred IUPAC name
(2R,6R)-6-[(1R,3S,3aR,4S,5aR,9aS,11aR)-3,4-Dihydroxy-3a,6,6,9a,11a-pentamethyl-7,10-dioxo-2,3,3a,4,5,5a,6,7,8,9,9a,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-1-yl]-2-methyl-4-oxoheptanoic acid
3D model (JSmol)
  • InChI=1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1 ☒N
  • InChI=1/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1
  • OC(=O)[C@H](C)CC(=O)C[C@@H](C)[C@H]2C[C@H](O)[C@@]1(C)C/3=C(\C(=O)C[C@@]12C)[C@@]4(C)CCC(=O)[C@](C)(C)[C@@H]4C[C@@H]\3O
Molar mass 516.67
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Ganoderic acids are a class of closely related triterpenoids (derivatives from lanosterol) found in Ganoderma mushrooms. For thousands of years, the fruiting bodies of Ganoderma fungi have been used in traditional medicines in East Asia.[1][2] Consequently, there have been efforts to identify the chemical constituents that may be responsible for the putative pharmacological effects. The two most well described ganoderic acids out of the many that have been identified and characterized are ganoderic acids A and B. Some ganoderic acids have been found to possess biological activities including hepatoprotection,[3] anti-tumor effects,[4] and 5-alpha reductase inhibition.[5]


  1. ^ Nishitoba, Tsuyoshi; Goto, Sanae; Sato, Hiroji; Sakamura, Sadao (1989). "Bitter triterpenoids from the fungus Ganoderma applanatum". Phytochemistry. 28 (1): 193–7. doi:10.1016/0031-9422(89)85036-8.
  2. ^ Mizuno, T.; Wang, G.; Zhang, J.; Kawagishi, H.; Nishitoba, T.; Li, J. (1995). "Reishi, Ganoderma lucidum and Ganoderma tsugae: Bioactive substances and medicinal effects". Food Reviews International. 11: 151–166. doi:10.1080/87559129509541025. closed access
  3. ^ Liu, Li-Ying; Chen, Hui; Liu, Chao; Wang, Hong-Qing; Kang, Jie; Li, Yan; Chen, Ruo-Yun (2014). "Triterpenoids of Ganoderma theaecolum and their hepatoprotective activities". Fitoterapia. 98: 254–9. doi:10.1016/j.fitote.2014.08.004. PMID 25111010.
  4. ^ Wang, G.; Zhao, J.; Liu, J.; Huang, Y.; Zhong, J. J.; Tang, W. (2007). "Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo". International Immunopharmacology. 7 (6): 864–870. doi:10.1016/j.intimp.2007.02.006. PMID 17466920. closed access
  5. ^ Liu, J.; Kurashiki, K.; Shimizu, K.; Kondo, R. (December 2006). "Structure–activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum". Bioorganic & Medicinal Chemistry. 14 (24): 8654–8660. doi:10.1016/j.bmc.2006.08.018. PMID 16962782. closed access