Gastric inhibitory polypeptide receptor

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GIPR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGIPR, PGQTL2, gastric inhibitory polypeptide receptor
External IDsOMIM: 137241 MGI: 1352753 HomoloGene: 20081 GeneCards: GIPR
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for GIPR
Genomic location for GIPR
Band19q13.32Start45,668,221 bp[1]
End45,683,722 bp[1]
RNA expression pattern
PBB GE GIPR 208105 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000164
NM_001308418

NM_001080815

RefSeq (protein)

NP_000155
NP_001295347

NP_001074284

Location (UCSC)Chr 19: 45.67 – 45.68 MbChr 7: 19.16 – 19.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The gastric inhibitory polypeptide receptor (GIP-R), also known as the glucose-dependent insulinotropic polypeptide receptor, is a protein that in humans is encoded by the GIPR gene.[5][6] GIP-R is a member of the 7-transmembrane protein family, a class of G protein–coupled receptors.[7] GIP-R is found on beta-cells in the pancreas.[8][9]

Function[edit]

Gastric inhibitory polypeptide (GIP), also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000010310 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030406 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: gastric inhibitory polypeptide receptor".
  6. ^ Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization". Genomics. 28 (3): 607–609. doi:10.1006/geno.1995.1203. PMID 7490109.
  7. ^ NCBI, NCBI Gene entry 2696 (GIPR), retrieved 2018-12-20.
  8. ^ "Gastrointestinal Hormones and Peptides". Retrieved 2007-08-24.
  9. ^ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (3–4): 179–188. doi:10.1080/10606820213687. PMID 12529935.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.