Gastric inhibitory polypeptide receptor

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Gastric inhibitory polypeptide receptor
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GIPR ; PGQTL2
External IDs OMIM137241 MGI1352753 HomoloGene20081 IUPHAR: 248 ChEMBL: 4383 GeneCards: GIPR Gene
RNA expression pattern
PBB GE GIPR 208105 at tn.png
More reference expression data
Species Human Mouse
Entrez 2696 381853
Ensembl ENSG00000010310 ENSMUSG00000030406
UniProt P48546 Q0P543
RefSeq (mRNA) NM_000164 NM_001080815
RefSeq (protein) NP_000155 NP_001074284
Location (UCSC) Chr 19:
45.67 – 45.68 Mb
Chr 7:
19.16 – 19.17 Mb
PubMed search [1] [2]

The gastric inhibitory polypeptide receptor (GIP-R) also known as the glucose-dependent insulinotropic polypeptide receptor is a protein that in humans is encoded by the GIPR gene.[1][2] The GIP-R is seven-transmembrane proteins found on beta-cells in the pancreas.[3][4]


Gastric inhibitory polypeptide (GIP), also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response.[1]


  1. ^ a b "Entrez Gene: gastric inhibitory polypeptide receptor". 
  2. ^ Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization". Genomics 28 (3): 607–609. doi:10.1006/geno.1995.1203. PMID 7490109. 
  3. ^ "Gastrointestinal Hormones and Peptides". Retrieved 2007-08-24. 
  4. ^ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels 8 (3–4): 179–188. doi:10.1080/10606820213687. PMID 12529935. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.