From Wikipedia, the free encyclopedia
Jump to: navigation, search
Protein PGC PDB 1avf.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases PGC, PEPC, PGII, gastricsin, progastricsin (pepsinogen C), progastricsin
External IDs MGI: 98909 HomoloGene: 55669 GeneCards: PGC
RNA expression pattern
PBB GE PGC 205261 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 41.74 – 41.75 Mb Chr 17: 47.73 – 47.73 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Gastricsin also known as pepsinogen C is an enzyme that in humans is encoded by the PGC gene.[3][4][5][6]


Gastricsin is an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself.[6]

Clinical significance[edit]

Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.[6]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hayano T, Sogawa K, Ichihara Y, Fujii-Kuriyama Y, Takahashi K (January 1988). "Primary structure of human pepsinogen C gene". J. Biol. Chem. 263 (3): 1382–5. PMID 3335549. 
  4. ^ Pals G, Azuma T, Mohandas TK, Bell GI, Bacon J, Samloff IM, Walz DA, Barr PJ, Taggart RT (February 1989). "Human pepsinogen C (progastricsin) polymorphism: evidence for a single locus located at 6p21.1-pter". Genomics. 4 (2): 137–48. doi:10.1016/0888-7543(89)90292-9. PMID 2567697. 
  5. ^ Taggart RT, Cass LG, Mohandas TK, Derby P, Barr PJ, Pals G, Bell GI (January 1989). "Human pepsinogen C (progastricsin). Isolation of cDNA clones, localization to chromosome 6, and sequence homology with pepsinogen A". J. Biol. Chem. 264 (1): 375–9. PMID 2909526. 
  6. ^ a b c "Entrez Gene: PGC progastricsin (pepsinogen C)". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.