|Latin||Tractus digestorius (mouth to anus),|
canalis alimentarius (esophagus to large intestine),
canalis gastrointestinales stomach to large intestine)
|Major parts of the|
The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines. Food taken in through the mouth is digested to extract nutrients and absorb energy, and the waste expelled at the anus as feces. Gastrointestinal is an adjective meaning of or pertaining to the stomach and intestines.
Most animals have a "through-gut" or complete digestive tract. Exceptions are more primitive ones: sponges have small pores (ostia) throughout their body for digestion and a larger dorsal pore (osculum) for excretion, comb jellies have both a ventral mouth and dorsal anal pores, while cnidarians and acoels have a single pore for both digestion and excretion.
The human gastrointestinal tract consists of the esophagus, stomach, and intestines, and is divided into the upper and lower gastrointestinal tracts. The GI tract includes all structures between the mouth and the anus, forming a continuous passageway that includes the main organs of digestion, namely, the stomach, small intestine, and large intestine. The complete human digestive system is made up of the gastrointestinal tract plus the accessory organs of digestion (the tongue, salivary glands, pancreas, liver and gallbladder). The tract may also be divided into foregut, midgut, and hindgut, reflecting the embryological origin of each segment. The whole human GI tract is about nine metres (30 feet) long at autopsy. It is considerably shorter in the living body because the intestines, which are tubes of smooth muscle tissue, maintain constant muscle tone in a halfway-tense state but can relax in spots to allow for local distention and peristalsis.
The gastrointestinal tract contains the gut microbiota, with some 4,000 different strains of bacteria having diverse roles in maintenance of immune health and metabolism, and many other microorganisms. Cells of the GI tract release hormones to help regulate the digestive process. These digestive hormones, including gastrin, secretin, cholecystokinin, and ghrelin, are mediated through either intracrine or autocrine mechanisms, indicating that the cells releasing these hormones are conserved structures throughout evolution.
Human gastrointestinal tract
The structure and function can be described both as gross anatomy and as microscopic anatomy or histology. The tract itself is divided into upper and lower tracts, and the intestines small and large parts.
Upper gastrointestinal tract
The upper gastrointestinal tract consists of the mouth, pharynx, esophagus, stomach, and duodenum. The exact demarcation between the upper and lower tracts is the suspensory muscle of the duodenum. This differentiates the embryonic borders between the foregut and midgut, and is also the division commonly used by clinicians to describe gastrointestinal bleeding as being of either "upper" or "lower" origin. Upon dissection, the duodenum may appear to be a unified organ, but it is divided into four segments based upon function, location, and internal anatomy. The four segments of the duodenum are as follows (starting at the stomach, and moving toward the jejunum): bulb, descending, horizontal, and ascending. The suspensory muscle attaches the superior border of the ascending duodenum to the diaphragm.
The suspensory muscle is an important anatomical landmark which shows the formal division between the duodenum and the jejunum, the first and second parts of the small intestine, respectively. This is a thin muscle which is derived from the embryonic mesoderm.
Lower gastrointestinal tract
The lower gastrointestinal tract includes most of the small intestine and all of the large intestine. In human anatomy, the intestine (bowel, or gut. Greek: éntera) is the segment of the gastrointestinal tract extending from the pyloric sphincter of the stomach to the anus and as in other mammals, consists of two segments: the small intestine and the large intestine. In humans, the small intestine is further subdivided into the duodenum, jejunum, and ileum while the large intestine is subdivided into the cecum, ascending, transverse, descending and sigmoid colon, rectum, and anal canal.
The small intestine begins at the duodenum and is a tubular structure, usually between 6 and 7 m long. Its mucosal area in an adult human is about 30 m2 (320 sq ft). The combination of the circular folds, the villi, and the microvilli increases the absorptive area of the mucosa about 600-fold, making a total area of about 250 m2 (2,700 sq ft) for the entire small intestine. Its main function is to absorb the products of digestion (including carbohydrates, proteins, lipids, and vitamins) into the bloodstream. There are three major divisions:
- Duodenum: A short structure (about 20–25 cm long) which receives chyme from the stomach, together with pancreatic juice containing digestive enzymes and bile from the gall bladder. The digestive enzymes break down proteins, and bile emulsifies fats into micelles. The duodenum contains Brunner's glands which produce a mucus-rich alkaline secretion containing bicarbonate. These secretions, in combination with bicarbonate from the pancreas, neutralize the stomach acids contained in the chyme.
- Jejunum: This is the midsection of the small intestine, connecting the duodenum to the ileum. It is about 2.5 m (8.2 ft) long and contains the circular folds also known as plicae circulares and villi that increase its surface area. Products of digestion (sugars, amino acids, and fatty acids) are absorbed into the bloodstream here.
- Ileum: The final section of the small intestine. It is about 3 m long, and contains villi similar to the jejunum. It absorbs mainly vitamin B12 and bile acids, as well as any other remaining nutrients.
- Cecum (first portion of the colon) and appendix
- Ascending colon (ascending in the back wall of the abdomen)
- Right colic flexure (flexed portion of the ascending and transverse colon apparent to the liver)
- Transverse colon (passing below the diaphragm)
- Left colic flexure (flexed portion of the transverse and descending colon apparent to the spleen)
- Descending colon (descending down the left side of the abdomen)
- Sigmoid colon (a loop of the colon closest to the rectum)
- Anal canal
The main function of the large intestine is to absorb water and salts. The area of the large intestinal mucosa of an adult human is about 2 m2 (22 sq ft).
The gut is an endoderm-derived structure. At approximately the sixteenth day of human development, the embryo begins to fold ventrally (with the embryo's ventral surface becoming concave) in two directions: the sides of the embryo fold in on each other and the head and tail fold toward one another. The result is that a piece of the yolk sac, an endoderm-lined structure in contact with the ventral aspect of the embryo, begins to be pinched off to become the primitive gut. The yolk sac remains connected to the gut tube via the vitelline duct. Usually, this structure regresses during development; in cases where it does not, it is known as Meckel's diverticulum.
During fetal life, the primitive gut is gradually patterned into three segments: foregut, midgut, and hindgut. Although these terms are often used in reference to segments of the primitive gut, they are also used regularly to describe regions of the definitive gut as well.
Each segment of the gut is further specified and gives rise to specific gut and gut-related structures in later development. Components derived from the gut proper, including the stomach and colon, develop as swellings or dilatations in the cells of the primitive gut. In contrast, gut-related derivatives — that is, those structures that derive from the primitive gut but are not part of the gut proper, in general, develop as out-pouchings of the primitive gut. The blood vessels supplying these structures remain constant throughout development.
|Part||Part in adult||Gives rise to||Arterial supply|
|Foregut||esophagus to first 2 sections of the duodenum||Esophagus, stomach, duodenum (1st and 2nd parts), liver, gallbladder, pancreas, superior portion of pancreas
(Note that though the spleen is supplied by the celiac trunk, it is derived from dorsal mesentery and therefore not a foregut derivative)
|Midgut||lower duodenum, to the first two-thirds of the transverse colon||lower duodenum, jejunum, ileum, cecum, appendix, ascending colon, and first two-thirds of the transverse colon||branches of the superior mesenteric artery|
|Hindgut||last third of the transverse colon, to the upper part of the anal canal||last third of the transverse colon, descending colon, rectum, and upper part of the anal canal||branches of the inferior mesenteric artery|
The gastrointestinal tract has a form of general histology with some differences that reflect the specialization in functional anatomy. The GI tract can be divided into four concentric layers in the following order:
The mucosa is the innermost layer of the gastrointestinal tract. The mucosa surrounds the lumen, or open space within the tube. This layer comes in direct contact with digested food (chyme). The mucosa is made up of:
- Epithelium – innermost layer. Responsible for most digestive, absorptive and secretory processes.
- Lamina propria – a layer of connective tissue. Unusually cellular compared to most connective tissue
- Muscularis mucosae – a thin layer of smooth muscle that aids the passing of material and enhances the interaction between the epithelial layer and the contents of the lumen by agitation and peristalsis
The mucosae are highly specialized in each organ of the gastrointestinal tract to deal with the different conditions. The most variation is seen in the epithelium.
The submucosa consists of a dense irregular layer of connective tissue with large blood vessels, lymphatics, and nerves branching into the mucosa and muscularis externa. It contains the submucosal plexus, an enteric nervous plexus, situated on the inner surface of the muscularis externa.
The muscular layer consists of an inner circular layer and a longitudinal outer layer. The circular layer prevents food from traveling backward and the longitudinal layer shortens the tract. The layers are not truly longitudinal or circular, rather the layers of muscle are helical with different pitches. The inner circular is helical with a steep pitch and the outer longitudinal is helical with a much shallower pitch. Whilst the muscularis externa is similar throughout the entire gastrointestinal tract, an exception is the stomach which has an additional inner oblique muscular layer to aid with grinding and mixing of food. The muscularis externa of the stomach is composed of the inner oblique layer, middle circular layer, and outer longitudinal layer.
Between the circular and longitudinal muscle layers is the myenteric plexus. This controls peristalsis. Activity is initiated by the pacemaker cells, (myenteric interstitial cells of Cajal). The gut has intrinsic peristaltic activity (basal electrical rhythm) due to its self-contained enteric nervous system. The rate can be modulated by the rest of the autonomic nervous system.
The coordinated contractions of these layers is called peristalsis and propels the food through the tract. Food in the GI tract is called a bolus (ball of food) from the mouth down to the stomach. After the stomach, the food is partially digested and semi-liquid, and is referred to as chyme. In the large intestine the remaining semi-solid substance is referred to as faeces.
Adventitia and serosa
The outermost layer of the gastrointestinal tract consists of several layers of connective tissue.
Intraperitoneal parts of the GI tract are covered with serosa. These include most of the stomach, first part of the duodenum, all of the small intestine, caecum and appendix, transverse colon, sigmoid colon and rectum. In these sections of the gut, there is a clear boundary between the gut and the surrounding tissue. These parts of the tract have a mesentery.
Retroperitoneal parts are covered with adventitia. They blend into the surrounding tissue and are fixed in position. For example, the retroperitoneal section of the duodenum usually passes through the transpyloric plane. These include the esophagus, pylorus of the stomach, distal duodenum, ascending colon, descending colon and anal canal. In addition, the oral cavity has adventitia.
Gene and protein expression
Approximately 20,000 protein coding genes are expressed in human cells and 75% of these genes are expressed in at least one of the different parts of the digestive organ system. Over 600 of these genes are more specifically expressed in one or more parts of the GI tract and the corresponding proteins have functions related to digestion of food and uptake of nutrients. Examples of specific proteins with such functions are pepsinogen PGC and the lipase LIPF, expressed in chief cells, and gastric ATPase ATP4A and gastric intrinsic factor GIF, expressed in parietal cells of the stomach mucosa. Specific proteins expressed in the stomach and duodenum involved in defence include mucin proteins, such as mucin 6 and intelectin-1.
The time taken for food to transit through the gastrointestinal tract varies on multiple factors, including age, ethnicity, and gender.[medical citation needed] Several techniques have been used to measure transit time, including radiography following a barium-labeled meal, breath hydrogen analysis, scintigraphic analysis following a radiolabeled meal, and simple ingestion and spotting of corn kernels. It takes 2.5 to 3 hours for 50% of the contents to leave the stomach.[medical citation needed] The rate of digestion is also dependent of the material being digested, as food composition from the same meal may leave the stomach at different rates.[medical citation needed] Total emptying of the stomach takes around 4–5 hours, and transit through the colon takes 30 to 50 hours.
The surface area of the digestive tract is estimated to be about 32 square meters, or about half a badminton court. With such a large exposure (more than three times larger than the exposed surface of the skin), these immune components function to prevent pathogens from entering the blood and lymph circulatory systems. Fundamental components of this protection are provided by the intestinal mucosal barrier, which is composed of physical, biochemical, and immune elements elaborated by the intestinal mucosa. Microorganisms also are kept at bay by an extensive immune system comprising the gut-associated lymphoid tissue (GALT)
There are additional factors contributing to protection from pathogen invasion. For example, low pH (ranging from 1 to 4) of the stomach is fatal for many microorganisms that enter it. Similarly, mucus (containing IgA antibodies) neutralizes many pathogenic microorganisms. Other factors in the GI tract contribution to immune function include enzymes secreted in the saliva and bile.
Immune system homeostasis
Beneficial bacteria also can contribute to the homeostasis of the gastrointestinal immune system. For example, Clostridia, one of the most predominant bacterial groups in the GI tract, play an important role in influencing the dynamics of the gut's immune system. It has been demonstrated that the intake of a high fiber diet could be responsible for the induction of T-regulatory cells (Tregs). This is due to the production of short-chain fatty acids during the fermentation of plant-derived nutrients such as butyrate and propionate. Basically, the butyrate induces the differentiation of Treg cells by enhancing histone H3 acetylation in the promoter and conserved non-coding sequence regions of the FOXP3 locus, thus regulating the T cells, resulting in the reduction of the inflammatory response and allergies.
The large intestine hosts several kinds of bacteria that can deal with molecules that the human body cannot otherwise break down. This is an example of symbiosis. These bacteria also account for the production of gases at host-pathogen interface inside the intestine (this gas is released as flatulence when eliminated through the anus). However the large intestine is mainly concerned with the absorption of water from digested material (which is regulated by the hypothalamus) and the reabsorption of sodium, as well as any nutrients that may have escaped primary digestion in the ileum.
Health-enhancing intestinal bacteria of the gut flora serve to prevent the overgrowth of potentially harmful bacteria in the gut. These two types of bacteria compete for space and "food", as there are limited resources within the intestinal tract. A ratio of 80-85% beneficial to 15–20% potentially harmful bacteria generally is considered normal within the intestines, and maintains homeostasis. A bad ratio of potentially harmful bacteria may disrupt this balance and cause dysbiosis.
Detoxification and drug metabolism
Various pathogens, such as bacteria that cause foodborne illnesses, can induce gastroenteritis which results from inflammation of the stomach and small intestine. Antibiotics to treat such bacterial infections can decrease the microbiome diversity of the gastrointestinal tract, and further enable inflammatory mediators. Gastroenteritis is the most common disease of the GI tract.
- Gastrointestinal cancer may occur at any point in the gastrointestinal tract, and includes mouth cancer, tongue cancer, oesophageal cancer, stomach cancer, and colorectal cancer.
- Inflammatory conditions. Ileitis is an inflammation of the ileum, colitis is an inflammation of the large intestine.
- Appendicitis is inflammation of the appendix located at the caecum. This is a potentially fatal condition if left untreated; most cases of appendicitis require surgical intervention.
Diverticular disease is a condition that is very common in older people in industrialized countries. It usually affects the large intestine but has been known to affect the small intestine as well. Diverticulosis occurs when pouches form on the intestinal wall. Once the pouches become inflamed it is known as diverticulitis.
Inflammatory bowel disease is an inflammatory condition affecting the bowel walls, and includes the subtypes Crohn's disease and ulcerative colitis. While Crohn's can affect the entire gastrointestinal tract, ulcerative colitis is limited to the large intestine. Crohn's disease is widely regarded as an autoimmune disease. Although ulcerative colitis is often treated as though it were an autoimmune disease, there is no consensus that it actually is such.
Functional gastrointestinal disorders the most common of which is irritable bowel syndrome. Functional constipation and chronic functional abdominal pain are other functional disorders of the intestine that have physiological causes but do not have identifiable structural, chemical, or infectious pathologies.
Several symptoms are used to indicate problems with the gastrointestinal tract:
- Vomiting, which may include regurgitation of food or the vomiting of blood
- Diarrhea, or the passage of liquid or more frequent stools
- Constipation, which refers to the passage of fewer and hardened stools
- Blood in stool, which includes fresh red blood, maroon-coloured blood, and tarry-coloured blood
Gastrointestinal surgery can often be performed in the outpatient setting. In the United States in 2012, operations on the digestive system accounted for 3 of the 25 most common ambulatory surgery procedures and constituted 9.1 percent of all outpatient ambulatory surgeries.
- Radioopaque dyes may be swallowed to produce a barium swallow
- Parts of the tract may be visualised by camera. This is known as endoscopy if examining the upper gastrointestinal tract and colonoscopy or sigmoidoscopy if examining the lower gastrointestinal tract. Capsule endoscopy is where a capsule containing a camera is swallowed in order to examine the tract. Biopsies may also be taken when examined.
- An abdominal x-ray may be used to examine the lower gastrointestinal tract.
- Enteric duplication cyst
- Peptic ulcer disease
- Yellow fever
- Helicobacter pylori is a gram-negative spiral bacterium. Over half the world's population is infected with it, mainly during childhood; it is not certain how the disease is transmitted. It colonizes the gastrointestinal system, predominantly the stomach. The bacterium has specific survival conditions that are specific to the human gastric microenvironment: it is both capnophilic and microaerophilic. Helicobacter also exhibits a tropism for gastric epithelial lining and the gastric mucosal layer about it. Gastric colonization of this bacterium triggers a robust immune response leading to moderate to severe inflammation, known as gastritis. Signs and symptoms of infection are gastritis, burning abdominal pain, weight loss, loss of appetite, bloating, burping, nausea, bloody vomit, and black tarry stools. Infection can be detected in a number of ways: GI X-rays, endoscopy, blood tests for anti-Helicobacter antibodies, a stool test, and a urease breath test (which is a by-product of the bacteria). If caught soon enough, it can be treated with three doses of different proton pump inhibitors as well as two antibiotics, taking about a week to cure. If not caught soon enough, surgery may be required.
- Intestinal pseudo-obstruction is a syndrome caused by a malformation of the digestive system, characterized by a severe impairment in the ability of the intestines to push and assimilate. Symptoms include daily abdominal and stomach pain, nausea, severe distension, vomiting, heartburn, dysphagia, diarrhea, constipation, dehydration and malnutrition. There is no cure for intestinal pseudo-obstruction. Different types of surgery and treatment managing life-threatening complications such as ileus and volvulus, intestinal stasis which lead to bacterial overgrowth, and resection of affected or dead parts of the gut may be needed. Many patients require parenteral nutrition.
- Ileus is a blockage of the intestines.
- Coeliac disease is a common form of malabsorption, affecting up to 1% of people of northern European descent. An autoimmune response is triggered in intestinal cells by digestion of gluten proteins. Ingestion of proteins found in wheat, barley and rye, causes villous atrophy in the small intestine. Lifelong dietary avoidance of these foodstuffs in a gluten-free diet is the only treatment.
- Enteroviruses are named by their transmission-route through the intestine (enteric meaning intestinal), but their symptoms aren't mainly associated with the intestine.
- Endometriosis can affect the intestines, with similar symptoms to IBS.
- Bowel twist (or similarly, bowel strangulation) is a comparatively rare event (usually developing sometime after major bowel surgery). It is, however, hard to diagnose correctly, and if left uncorrected can lead to bowel infarction and death. (The singer Maurice Gibb is understood to have died from this.)
- Angiodysplasia of the colon
- Hirschsprung's disease (aganglionosis)
- Polyp (medicine) (see also colorectal polyp)
- Pseudomembranous colitis
- Toxic megacolon usually a complication of ulcerative colitis
Uses of animal guts
Intestines from animals other than humans are used in a number of ways. From each species of livestock that is a source of milk, a corresponding rennet is obtained from the intestines of milk-fed calves. Pig and calf intestines are eaten, and pig intestines are used as sausage casings. Calf intestines supply calf-intestinal alkaline phosphatase (CIP), and are used to make goldbeater's skin. Other uses are:
- The use of animal gut strings by musicians can be traced back to the third dynasty of Egypt. In the recent past, strings were made out of lamb gut. With the advent of the modern era, musicians have tended to use strings made of silk, or synthetic materials such as nylon or steel. Some instrumentalists, however, still use gut strings in order to evoke the older tone quality. Although such strings were commonly referred to as "catgut" strings, cats were never used as a source for gut strings.
- Sheep gut was the original source for natural gut string used in racquets, such as for tennis. Today, synthetic strings are much more common, but the best gut strings are now made out of cow gut.
- Gut cord has also been used to produce strings for the snares that provide a snare drum's characteristic buzzing timbre. While the modern snare drum almost always uses metal wire rather than gut cord, the North African bendir frame drum still uses gut for this purpose.
- "Natural" sausage hulls, or casings, are made of animal gut, especially hog, beef, and lamb.
- The wrapping of kokoretsi, gardoubakia, and torcinello is made of lamb (or goat) gut.
- Haggis is traditionally boiled in, and served in, a sheep stomach.
- Chitterlings, a kind of food, consist of thoroughly washed pig's gut.
- Animal gut was used to make the cord lines in longcase clocks and for fusee movements in bracket clocks, but may be replaced by metal wire.
- The oldest known condoms, from 1640 AD, were made from animal intestine.
Many birds and other animals have a specialised stomach in the digestive tract called a gizzard used for grinding up food.
Another feature not found in the human but found in a range of other animals is the crop. In birds this is found as a pouch alongside the esophagus.
Most vertebrates including fishes, amphibians, birds, reptiles, and egg-laying mammals have a major difference in their GI tract in that it ends in a cloaca and not an anus, having merged the urinary system with the genito-anal pore. Therians (most/other mammals, including humans) separated their anus from their uro-genital opening for both sexes, with subgroup placentalians later separating their urinary and genital openings by a little distance, this time only in females.
A through-gut (one with both mouth and anus) is thought to have evolved within the nephrozoan clade of Bilateria, after their ancestral ventral orifice (single, as in cnidarians and acoels; re-evolved in nephrozoans like flatworms) stretched antero-posteriorly, before the middle part of the stretch would get narrower and closed fully, leaving an anterior orifice (mouth) and a posterior orifice (anus plus genital opening). A stretched gut without the middle part closed is present in another branch of bilaterians, the extinct proarticulates. This and the amphistomic development (when both mouth and anus develop from the gut stretch in the embryo) present in some nephrozoans (e.g. roundworms) are considered to support this hypothesis.
- Gastrointestinal physiology
- All pages with titles beginning with Gastrointestinal
- All pages with titles containing Gastrointestinal
- "Overview of Invertebrates". www.ck12.org. 6 October 2015. Retrieved 25 June 2021.
- Ruppert EE, Fox RS, Barnes RD (2004). "Introduction to Bilateria". Invertebrate Zoology (7 ed.). Brooks / Cole. p. 197 . ISBN 978-0-03-025982-1.
- "gastrointestinal tract" at Dorland's Medical Dictionary
- Gastrointestinal+tract at the US National Library of Medicine Medical Subject Headings (MeSH)
- "digestive system" at Dorland's Medical Dictionary
- G., Hounnou; C., Destrieux; J., Desmé; P., Bertrand; S., Velut (2002-12-01). "Anatomical study of the length of the human intestine". Surgical and Radiologic Anatomy. 24 (5): 290–294. doi:10.1007/s00276-002-0057-y. ISSN 0930-1038. PMID 12497219. S2CID 33366428.
- Raines, Daniel; Arbour, Adrienne; Thompson, Hilary W.; Figueroa-Bodine, Jazmin; Joseph, Saju (2014-05-26). "Variation in small bowel length: Factor in achieving total enteroscopy?". Digestive Endoscopy. 27 (1): 67–72. doi:10.1111/den.12309. ISSN 0915-5635. PMID 24861190. S2CID 19069407.
- Lin, L; Zhang, J (2017). "Role of intestinal microbiota and metabolites on gut homeostasis and human diseases". BMC Immunology. 18 (1): 2. doi:10.1186/s12865-016-0187-3. PMC 5219689. PMID 28061847.
- Marchesi, J. R; Adams, D. H; Fava, F; Hermes, G. D; Hirschfield, G. M; Hold, G; Quraishi, M. N; Kinross, J; Smidt, H; Tuohy, K. M; Thomas, L. V; Zoetendal, E. G; Hart, A (2015). "The gut microbiota and host health: A new clinical frontier". Gut. 65 (2): 330–339. doi:10.1136/gutjnl-2015-309990. PMC 4752653. PMID 26338727.
- Clarke, Gerard; Stilling, Roman M; Kennedy, Paul J; Stanton, Catherine; Cryan, John F; Dinan, Timothy G (2014). "Minireview: Gut Microbiota: The Neglected Endocrine Organ". Molecular Endocrinology. 28 (8): 1221–38. doi:10.1210/me.2014-1108. PMC 5414803. PMID 24892638.
- Nelson RJ. 2005. Introduction to Behavioral Endocrinology. Sinauer Associates: Massachusetts. p 57.
- Thomasino, Anne Marie (2001). "Length of a Human Intestine". The Physics Factbook.
- Upper+Gastrointestinal+Tract at the US National Library of Medicine Medical Subject Headings (MeSH)
- David A. Warrell (2005). Oxford textbook of medicine: Sections 18-33. Oxford University Press. pp. 511–. ISBN 978-0-19-856978-7. Retrieved 1 July 2010.
- Lower+Gastrointestinal+Tract at the US National Library of Medicine Medical Subject Headings (MeSH)
- Kapoor, Vinay Kumar (13 Jul 2011). Gest, Thomas R. (ed.). "Large Intestine Anatomy". Medscape. WebMD LLC. Retrieved 2013-08-20.
- Gray, Henry (1918). Gray's Anatomy. Philadelphia: Lea & Febiger.
- Drake, Richard L.; Vogl, Wayne; Tibbitts, Adam W.M. Mitchell; illustrations by Richard; Richardson, Paul (2015). Gray's anatomy for students (3rd ed.). Philadelphia: Elsevier/Churchill Livingstone. p. 312. ISBN 978-0-8089-2306-0.
- Helander, Herbert F.; Fändriks, Lars (2014-06-01). "Surface area of the digestive tract - revisited". Scandinavian Journal of Gastroenterology. 49 (6): 681–689. doi:10.3109/00365521.2014.898326. ISSN 1502-7708. PMID 24694282. S2CID 11094705.
- Hall, John (2011). Guyton and Hall textbook of medical physiology (Twelfth ed.). p. 794. ISBN 9781416045748.
- Bruce M. Carlson (2004). Human Embryology and Developmental Biology (3rd ed.). Saint Louis: Mosby. ISBN 978-0-323-03649-8.
- Abraham L. Kierszenbaum (2002). Histology and cell biology: an introduction to pathology. St. Louis: Mosby. ISBN 978-0-323-01639-1.
- Sarna, S.K. (2010). "Introduction". Colonic Motility: From Bench Side to Bedside. San Rafael, California: Morgan & Claypool Life Sciences. ISBN 9781615041503.
- "The human proteome in gastrointestinal tract - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2017-09-21.
- Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; Lindskog, Cecilia; Oksvold, Per; Mardinoglu, Adil; Sivertsson, Åsa; Kampf, Caroline; Sjöstedt, Evelina (2015-01-23). "Tissue-based map of the human proteome". Science. 347 (6220): 1260419. doi:10.1126/science.1260419. ISSN 0036-8075. PMID 25613900. S2CID 802377.
- Gremel, Gabriela; Wanders, Alkwin; Cedernaes, Jonathan; Fagerberg, Linn; Hallström, Björn; Edlund, Karolina; Sjöstedt, Evelina; Uhlén, Mathias; Pontén, Fredrik (2015-01-01). "The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling". Journal of Gastroenterology. 50 (1): 46–57. doi:10.1007/s00535-014-0958-7. ISSN 0944-1174. PMID 24789573. S2CID 21302849.
- Bowen, Richard. "Gastrointestinal Transit: How Long Does It Take?". Colorado State University.
- Keendjele, Tuwilika P. T.; Eelu, Hilja H.; Nashihanga, Tunelago E.; Rennie, Timothy W.; Hunter, Christian John (1 March 2021). "Corn? When did I eat corn? Gastrointestinal transit time in health science students". Advances in Physiology Education. 45 (1): 103–108. doi:10.1152/advan.00192.2020. PMID 33544037. S2CID 231817664.
- Kim, SK (1968). "Small intestine transit time in the normal small bowel study". American Journal of Roentgenology. 104 (3): 522–524. doi:10.2214/ajr.104.3.522. PMID 5687899.
- Ghoshal, U. C.; Sengar, V.; Srivastava, D. (2012). "Colonic Transit Study Technique and Interpretation: Can These be Uniform Globally in Different Populations with Non-uniform Colon Transit Time?". Journal of Neurogastroenterology and Motility. 18 (2): 227–228. doi:10.5056/jnm.2012.18.2.227. PMC 3325313. PMID 22523737.
- Mowat, Allan M.; Agace, William W. (2014-10-01). "Regional specialization within the intestinal immune system". Nature Reviews. Immunology. 14 (10): 667–685. doi:10.1038/nri3738. ISSN 1474-1741. PMID 25234148. S2CID 31460146.
- Flannigan, Kyle L.; Geem, Duke; Harusato, Akihito; Denning, Timothy L. (2015-07-01). "Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation". The American Journal of Pathology. 185 (7): 1809–1819. doi:10.1016/j.ajpath.2015.02.024. ISSN 1525-2191. PMC 4483458. PMID 25976247.
- Sánchez de Medina, Fermín; Romero-Calvo, Isabel; Mascaraque, Cristina; Martínez-Augustin, Olga (2014-12-01). "Intestinal inflammation and mucosal barrier function". Inflammatory Bowel Diseases. 20 (12): 2394–2404. doi:10.1097/MIB.0000000000000204. ISSN 1536-4844. PMID 25222662. S2CID 11434730.
- Schubert, Mitchell L. (2014-11-01). "Gastric secretion". Current Opinion in Gastroenterology. 30 (6): 578–582. doi:10.1097/MOG.0000000000000125. ISSN 1531-7056. PMID 25211241. S2CID 8267813.
- Márquez, Mercedes; Fernández Gutiérrez Del Álamo, Clotilde; Girón-González, José Antonio (2016-01-28). "Gut epithelial barrier dysfunction in human immunodeficiency virus-hepatitis C virus coinfected patients: Influence on innate and acquired immunity". World Journal of Gastroenterology. 22 (4): 1433–1448. doi:10.3748/wjg.v22.i4.1433. ISSN 2219-2840. PMC 4721978. PMID 26819512.
- Furusawa, Yukihiro; Obata, Yuuki; Fukuda, Shinji; Endo, Takaho A.; Nakato, Gaku; Takahashi, Daisuke; Nakanishi, Yumiko; Uetake, Chikako; Kato, Keiko; Kato, Tamotsu; Takahashi, Masumi; Fukuda, Noriko N.; Murakami, Shinnosuke; Miyauchi, Eiji; Hino, Shingo; Atarashi, Koji; Onawa, Satoshi; Fujimura, Yumiko; Lockett, Trevor; Clarke, Julie M.; Topping, David L.; Tomita, Masaru; Hori, Shohei; Ohara, Osamu; Morita, Tatsuya; Koseki, Haruhiko; Kikuchi, Jun; Honda, Kenya; Hase, Koji; Ohno, Hiroshi (2013). "Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells". Nature. 504 (7480): 446–450. Bibcode:2013Natur.504..446F. doi:10.1038/nature12721. PMID 24226770. S2CID 4408815.
- Knight, Judson (2002). Science of Everyday Things: Real-life biology. Vol. 4. ISBN 9780787656348.
- Jakoby, WB; Ziegler, DM (5 December 1990). "The enzymes of detoxication". The Journal of Biological Chemistry. 265 (34): 20715–8. doi:10.1016/S0021-9258(17)45272-0. PMID 2249981.
- Nitzan, Orna; Elias, Mazen; Peretz, Avi; Saliba, Walid (2016-01-21). "Role of antibiotics for treatment of inflammatory bowel disease". World Journal of Gastroenterology. 22 (3): 1078–1087. doi:10.3748/wjg.v22.i3.1078. ISSN 1007-9327. PMC 4716021. PMID 26811648.
- Wier LM, Steiner CA, Owens PL (February 2015). "Surgeries in Hospital-Owned Outpatient Facilities, 2012". HCUP Statistical Brief #188. Rockville, MD: Agency for Healthcare Research and Quality.
- Fox, James; Timothy Wang (January 2007). "Inflammation, Atrophy, and Gastric Cancer". Journal of Clinical Investigation. review. 117 (1): 60–69. doi:10.1172/JCI30111. PMC 1716216. PMID 17200707.
- Murphy, Kenneth (20 May 2014). Janeway's Immunobiology. New York: Garland Science, Taylor and Francis Group, LLC. pp. 389–398. ISBN 978-0-8153-4243-4.
- Parham, Peter (20 May 2014). The Immune System. New York: Garland Science Taylor and Francis Group LLC. p. 494. ISBN 978-0-8153-4146-8.
- Goering, Richard (20 May 2014). MIMS Medical Microbiology. Philadelphia: Elsevier. pp. 32, 64, 294, 133–4, 208, 303–4, 502. ISBN 978-0-3230-4475-2.
- Hiskey, Daven (12 November 2010). "Violin strings were never made out of actual cat guts". TodayIFoundOut.com. Retrieved 15 December 2015.
- "World's oldest condom". Ananova. 2008. Retrieved 2008-04-11.
- Joel, Lucas (10 January 2020). "Fossil Reveals Earth's Oldest Known Animal Guts - The find in a Nevada desert revealed an intestine inside a creature that looks like a worm made of a stack of ice cream cones". The New York Times. Retrieved 10 January 2020.
- Svhiffbauer, James D.; et al. (10 January 2020). "Discovery of bilaterian-type through-guts in cloudinomorphs from the terminal Ediacaran Period". Nature Communications. 11 (205): 205. Bibcode:2020NatCo..11..205S. doi:10.1038/s41467-019-13882-z. PMC 6954273. PMID 31924764.
- Nielsen, C., Brunet, T. & Arendt, D. Evolution of the bilaterian mouth and anus. Nat Ecol Evol 2, 1358–1376 (2018). https://doi.org/10.1038/s41559-018-0641-0
- De Robertis, E. M., & Tejeda-Muñoz, N. (2022). Evo-Devo of urbilateria and its larval forms. Developmental Biology, 487, 10–20. https://doi.org/10.1016/j.ydbio.2022.04.003