Gate control theory
Ronald Melzack, a Canadian researcher, proposed the gate control theory with Patrick David Wall in 1965. The gate control theory of pain asserts that non-painful input closes the "gates" to painful input, which prevents pain sensation from traveling to the central nervous system. Therefore, stimulation by non-noxious input is able to suppress pain.
First proposed in 1965 by Ronald Melzack and Patrick Wall, the theory offers a physiological explanation for the previously observed effect of psychology on pain perception. Combining early concepts derived from the specificity theory and the peripheral pattern theory, the gate control theory is considered to be one of the most influential theories of pain because it provided a neural basis which reconciled the specificity and pattern theories and ultimately revolutionized pain research.
Although there are some important observations which the gate control theory cannot explain adequately, it remains the only theory of pain that most accurately accounts for the physical and psychological aspects of pain perception.
Willem Noordenbos (1910-1990), a Dutch researcher at the University of Amsterdam, was the first one to propose a model with an interaction between small (unmyelinated) and thick (myelinated) fibers in 1959. The fast (myelinated) fibers block the slow (unmyelinated) fibers, "fast blocks slow".
Ronald Melzack and Patrick Wall introduced their "gate control" theory of pain in the 1965 Science article "Pain Mechanisms: A New Theory". The authors proposed that both thin (pain) and large diameter (touch, pressure, vibration) nerve fibers carry information from the site of injury to two destinations in the dorsal horn of the spinal cord: transmission cells that carry the pain signal up to the brain, and inhibitory interneurons that impede transmission cell activity. Activity in both thin and large diameter fibers excites transmission cells. Thin fiber activity impedes the inhibitory cells (tending to allow the transmission cell to fire) and large diameter fiber activity excites the inhibitory cells (tending to inhibit transmission cell activity). So, the more large fiber (touch, pressure, vibration) activity relative to thin fiber activity at the inhibitory cell, the less pain is felt. The authors had drawn a neural "circuit diagram" to explain why we rub a smack. They pictured not only a signal traveling from the site of injury to the inhibitory and transmission cells and up the spinal cord to the brain, but also a signal traveling from the site of injury directly up the cord to the brain (bypassing the inhibitory and transmission cells) where, depending on the state of the brain, it may trigger a signal back down the spinal cord to modulate inhibitory cell activity (and so pain intensity). The theory offered a physiological explanation for the previously observed effect of psychology on pain perception.
Gate control theory asserts that activation of nerves which do not transmit pain signals, called nonnociceptive fibers, can interfere with signals from pain fibers, thereby inhibiting pain. Afferent pain-receptive nerves, those that bring signals to the brain, comprise at least two kinds of fibers - a fast, relatively thick, myelinated "Aδ" fiber that carries messages quickly with intense pain, and a small, unmyelinated, slow "C" fiber that carries the longer-term throbbing and chronic pain. Large-diameter Aβ fibers are nonnociceptive (do not transmit pain stimuli) and inhibit the effects of firing by Aδ and C fibers.
The peripheral nervous system has centers at which pain stimuli can be regulated. Some areas in the dorsal horn of the spinal cord that are involved in receiving pain stimuli from Aδ and C fibers, called laminae, also receive input from Aβ fibers. The nonnociceptive fibers indirectly inhibit the effects of the pain fibers, 'closing a gate' to the transmission of their stimuli. In other parts of the laminae, pain fibers also inhibit the effects of nonnociceptive fibers, 'opening the gate'. This presynaptic inhibition of the dorsal nerve endings can occur through specific types of GABAA receptors (not through the α1 GABAA receptor and not through the activation of glycine receptors which are also absent from these types of terminals). Thus certain GABAA receptor subtypes but not glycine receptors can presynaptically regulate nociception and pain transmission.
An inhibitory connection may exist with Aβ and C fibers, which may form a synapse on the same projection neuron. The same neurons may also form synapses with an inhibitory interneuron that also synapses on the projection neuron, reducing the chance that the latter will fire and transmit pain stimuli to the brain (image on the right). The inhibitory interneuron fires spontaneously. The C fiber's synapse would inhibit the inhibitory interneuron, indirectly increasing the projection neuron's chance of firing. The Aβ fiber, on the other hand, forms an excitatory connection with the inhibitory interneuron, thus decreasing the projection neuron's chance of firing (like the C fiber, the Aβ fiber also has an excitatory connection on the projection neuron itself). Thus, depending on the relative rates of firing of C and Aβ fibers, the firing of the nonnociceptive fiber may inhibit the firing of the projection neuron and the transmission of pain stimuli.
Gate control theory thus explains how stimulus that activates only nonnociceptive nerves can inhibit pain. The pain seems to be lessened when the area is rubbed because activation of nonnociceptive fibers inhibits the firing of nociceptive ones in the laminae. In transcutaneous electrical nerve stimulation (TENS), nonnociceptive fibers are selectively stimulated with electrodes in order to produce this effect and thereby lessen pain.
One area of the brain involved in reduction of pain sensation is the periaqueductal gray matter that surrounds the third ventricle and the cerebral aqueduct of the ventricular system. Stimulation of this area produces analgesia (but not total numbing) by activating descending pathways that directly and indirectly inhibit nociceptors in the laminae of the spinal cord. Descending pathways also activate opioid receptor-containing parts of the spinal cord.
Afferent pathways interfere with each other constructively, so that the brain can control the degree of pain that is perceived, based on which pain stimuli are to be ignored to pursue potential gains. The brain determines which stimuli are profitable to ignore over time. Thus, the brain controls the perception of pain quite directly, and can be "trained" to turn off forms of pain that are not "useful". This understanding led Melzack to assert that pain is in the brain.
In 1968, three years after the introduction of the gate control theory, Ronald Melzack concluded that pain is a multidimensional complex with numerous sensory, affective, cognitive, and evaluative components. Melzack's description has been adapted by the International Association for the Study of Pain in a contemporary definition of pain. Despite flaws in its presentation of neural architecture, the theory of gate control is currently the only theory that most accurately accounts for the physical and psychological aspects of pain.
The gate control theory ended a century-old debate about whether pain is represented by specific neural elements (specificity theory) or by patterned activity (pattern theory) within a convergent somatosensory subsystem. Although it is now considered to be oversimplified with flaws in the presentation of neural architecture, the gate control theory spurred many studies in pain research and significantly advanced our understanding of pain.
Today, it is generally accepted that modern pain research began with the publication of the Gate Control Theory of Pain.
- Moayedi, M.; Davis, K. D. (3 October 2012). "Theories of pain: from specificity to gate control". Journal of Neurophysiology 109 (1): 5–12. doi:10.1152/jn.00457.2012.
- Meldrum, Marcia L. "Physiology of pain". Encyclopædia Britannica. Retrieved 27 April 2014.
The theory of pain that most accurately accounts for the physical and psychological aspects of pain is the gate-control theory
- Mander, Rosemary (2010). Pain in Childbearing and its Control: Key Issues for Midwives and Women. John Wiley & Sons.
- Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150(3699):971–9. doi:10.1126/science.150.3699.971. PMID 5320816.
- Melzack R, Katz J. The Gate Control Theory: Reaching for the Brain. In: Craig KD, Hadjistavropoulos T. Pain: psychological perspectives. Mahwah, N.J: Lawrence Erlbaum Associates, Publishers; 2004. ISBN 0-8058-4299-3.
- Skevington, Suzanne. Psychology of pain. New York: Wiley; 1995. ISBN 0-471-95771-2. p. 11.
- Kandel, Eric R.; James H. Schwartz; Thomas M. Jessell (2000). Principles of Neural Science (4th ed.). New York: McGraw-Hill. pp. 482–486. ISBN 0-8385-7701-6.
- Lorenzo LE, Godin AG, Wang F, St-Louis M, Carbonetto S, Wiseman PW, Ribeiro-da-Silva A, De Koninck Y (June 2014). "Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite the Presence of GABAA Receptors". J. Neurosci. 34 (24): 8300–17. doi:10.1523/JNEUROSCI.0159-14.2014. PMID 24920633.
- "Patrick Wall, 76, British Authority on Pain". The New York Times. 21 August 2001. Retrieved 27 April 2014.
- Craig, James C.; Rollman, Gary B. (February 1999). "SOMESTHESIS". Annual Review of Psychology 50 (1): 305–331. doi:10.1146/annurev.psych.50.1.305.
- Craig, A.D. (Bud) (March 2003). "Pain Mechanisms: Labeled Lines Versus Convergence in Central Processing". Annual Review of Neuroscience 26 (1): 1–30. doi:10.1146/annurev.neuro.26.041002.131022. PMID 12651967.
- Cervero, F. (23 June 2013). "III. Pain research: what have we learned and where are we going". British Journal of Anaesthesia 111 (1): 6–8. doi:10.1093/bja/aet209.
Modern pain research began in the mid 1960s with the publication of the Gate Control Theory of Pain