Gem-associated protein 2

GEMIN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LEH, 3S6N
Identifiers
Aliases	GEMIN2, SIP1, SIP1-delta, Survival of motor neuron protein-interacting protein 1, gem nuclear organelle associated protein 2
External IDs	OMIM: 602595; MGI: 1913853; HomoloGene: 37827; GeneCards: GEMIN2; OMA:GEMIN2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	39,136,973 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	59,075,256 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; secondary oocyte; ; sperm; ; ventricular zone; ; ganglionic eminence; ; gonad; ; right testis; ; left testis; ; testicle; ; gastrocnemius muscle;
	Top expressed in
	morula; ; otic placode; ; epiblast; ; embryo; ; embryo; ; endocardial cushion; ; primitive streak; ; otic vesicle; ; abdominal wall; ; ureter;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	SMN complex; SMN-Sm protein complex; cytosol; spliceosomal complex; nucleolus; intracellular anatomical structure; nucleus; nucleoplasm; cytoplasm; nuclear body; gemini of coiled bodies;
Biological process	RNA splicing, via transesterification reactions; mRNA processing; spliceosomal complex assembly; RNA splicing; spliceosomal snRNP assembly; import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	8487
	66603
	ENSG00000092208
	ENSMUSG00000060121
	O14893
	Q9CQQ4
	NM_001009182; NM_001009183; NM_003616
	NM_025656
	NP_001009182; NP_001009183; NP_003607
	NP_079932
	Wikidata
View/Edit Human	View/Edit Mouse

Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that in humans is encoded by the GEMIN2 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

Gem-associated protein 2 has been shown to interact with DDX20^[8]^[9] and SMN1.^[6]^[10]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000092208 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060121 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fischer U, Liu Q, Dreyfuss G (October 1997). "The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis". Cell. 90 (6): 1023–9. doi:10.1016/S0092-8674(00)80368-2. PMID 9323130.
^ ^a ^b Liu Q, Fischer U, Wang F, Dreyfuss G (October 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129.
^ "Entrez Gene: SIP1 survival of motor neuron protein interacting protein 1".
^ Mourelatos, Zissimos; Dostie Josée; Paushkin Sergey; Sharma Anup; Charroux Bernard; Abel Linda; Rappsilber Juri; Mann Matthias; Dreyfuss Gideon (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6). United States: 720–8. doi:10.1101/gad.974702. ISSN 0890-9369. PMC 155365. PMID 11914277. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (December 1999). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. 147 (6). UNITED STATES: 1181–94. doi:10.1083/jcb.147.6.1181. ISSN 0021-9525. PMC 2168095. PMID 10601333. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Carnegie, Graeme K; Sleeman Judith E; Morrice Nick; Hastie C James; Peggie Mark W; Philp Amanda; Lamond Angus I; Cohen Patricia T W (May 2003). "Protein phosphatase 4 interacts with the Survival of motor neurons complex and enhances the temporal localisation of snRNPs". J. Cell. Sci. 116 (Pt 10). England: 1905–13. doi:10.1242/jcs.00409. ISSN 0021-9533. PMID 12668731. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Meister, G; Bühler D; Laggerbauer B; Zobawa M; Lottspeich F; Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13). ENGLAND: 1977–86. doi:10.1093/hmg/9.13.1977. ISSN 0964-6906. PMID 10942426. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Gem-associated protein 2

Interactions

See also

References

Further reading