Gem-associated protein 6

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GEMIN6
Protein GEMIN6 PDB 1y96.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGEMIN6, gem nuclear organelle associated protein 6
External IDsMGI: 1914492 HomoloGene: 11711 GeneCards: GEMIN6
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for GEMIN6
Genomic location for GEMIN6
Band2p22.1Start38,751,534 bp[1]
End38,785,002 bp[1]
RNA expression pattern
PBB GE GEMIN6 219539 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024775

NM_026053
NM_001355458

RefSeq (protein)

NP_079051

NP_080329
NP_001342387

Location (UCSC)Chr 2: 38.75 – 38.79 MbChr 17: 80.22 – 80.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene.[5][6]The gem-associated proteins are those found in the gems of Cajal bodies.

Function[edit]

GEMIN6 is part of a large macromolecular complex, the SMN localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM][6]

Interactions[edit]

Gem-associated protein 6 has been shown to interact with gem-associated protein 7.[7][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152147 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055760 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
  6. ^ a b "Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6".
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  8. ^ Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.

Further reading[edit]

  • Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
  • Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (Jun 2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure. 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.
  • Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex". The Journal of Biological Chemistry. 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.