Gem-associated protein 7

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Gem (nuclear organelle) associated protein 7
Protein GEMIN7 PDB 1y96.png
PDB rendering based on 1y96.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GEMIN7 ; SIP3
External IDs OMIM607419 MGI1916981 HomoloGene11668 GeneCards: GEMIN7 Gene
RNA expression pattern
PBB GE GEMIN7 219085 s at tn.png
More reference expression data
Species Human Mouse
Entrez 79760 69731
Ensembl ENSG00000142252 ENSMUSG00000044709
UniProt Q9H840 Q9CWY4
RefSeq (mRNA) NM_001007269 NM_027189
RefSeq (protein) NP_001007270 NP_081465
Location (UCSC) Chr 19:
45.08 – 45.09 Mb
Chr 7:
19.56 – 19.57 Mb
PubMed search [1] [2]

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene.[1][2]


The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.[2]


Gem-associated protein 7 has been shown to interact with SMN1[1][3] and Gem-associated protein 6.[1][4]


  1. ^ a b c Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586. 
  2. ^ a b "Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7". 
  3. ^ Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230. 
  4. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]

  • Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex". The Journal of Biological Chemistry 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415. 
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • Grimmler M, Otter S, Peter C, Müller F, Chari A, Fischer U (Oct 2005). "Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization". Human Molecular Genetics 14 (20): 3099–111. doi:10.1093/hmg/ddi343. PMID 16159890.