|Other names||Gender identity disorder|
|Symptoms||Distress related to one's assigned gender or sex|
|Complications||Eating disorders, suicide, depression, anxiety, social isolation|
|Differential diagnosis||Variance in gender identity or expression that is not distressing|
|Medication||Hormones (e.g., androgens, antiandrogens, estrogens)|
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Gender dysphoria (GD) is the distress a person feels due to a mismatch between their gender identity and their assigned sex. The diagnostic label gender identity disorder (GID) was used until 2013 with the release of the DSM-5. The condition was renamed to remove the stigma associated with the term disorder.
People with gender dysphoria commonly identify as transgender. Gender nonconformity is not the same thing as gender dysphoria and does not always lead to dysphoria or distress. According to the American Psychiatric Association, the critical element of gender dysphoria is "clinically significant distress".
Treatment for gender dysphoria may involve supporting the person through changes in gender expression. Hormone therapy or surgery may be used to assist such changes. Treatment may also include counseling or psychotherapy.
Signs and symptoms
Gender dysphoria in those assigned male at birth tends to follow one of two broad trajectories: early-onset or late-onset. Early-onset gender dysphoria is behaviorally visible in childhood. Sometimes gender dysphoria will desist in this group and they will identify as gay or homosexual for a period of time, followed by recurrence of gender dysphoria. This group is usually sexually attracted to members of their natal sex in adulthood. Late-onset gender dysphoria does not include visible signs in early childhood, but some report having had wishes to be the opposite sex in childhood that they did not report to others. Trans women who experience late-onset gender dysphoria will usually be sexually attracted to women and may identify as lesbians. It is common for people assigned male at birth who have late-onset gender dysphoria to engage in cross-dressing with sexual excitement. In those assigned female at birth, early-onset gender dysphoria is the most common course. This group is usually sexually attracted to women. Trans men who experience late-onset gender dysphoria will usually be sexually attracted to men and may identify as gay.
Symptoms of GD in children include preferences for opposite sex-typical toys, games, or activities; great dislike of their own genitalia; and a strong preference for playmates of the opposite sex. Some children may also experience social isolation from their peers, anxiety, loneliness, and depression.
In adolescents and adults, symptoms include the desire to be and to be treated as the other sex. Adults with GD are at increased risk for stress, isolation, anxiety, depression, poor self-esteem, and suicide. Transgender people are also at heightened risk for eating disorders and substance abuse.
The specific causes of gender dysphoria remain unknown, and treatments targeting the etiology or pathogenesis of gender dysphoria do not exist. Evidence from studies of twins suggests that genetic factors play a role in the development of gender dysphoria and gender identity is thought to likely reflect a complex interplay of biological, environmental, and cultural factors.
- A strong desire to be of a gender other than one's assigned gender
- A strong desire to be treated as a gender other than one's assigned gender
- A significant incongruence between one's experienced or expressed gender and one's sexual characteristics
- A strong desire for the sexual characteristics of a gender other than one's assigned gender
- A strong desire to be rid of one's sexual characteristics due to incongruence with one's experienced or expressed gender
- A strong conviction that one has the typical reactions and feelings of a gender other than one's assigned gender
In addition, the condition must be associated with clinically significant distress or impairment.
The DSM-5 moved this diagnosis out of the sexual disorders category and into a category of its own. The diagnosis was renamed from gender identity disorder to gender dysphoria, after criticisms that the former term was stigmatizing. Subtyping by sexual orientation was deleted. The diagnosis for children was separated from that for adults, as "gender dysphoria in children". The creation of a specific diagnosis for children reflects the lesser ability of children to have insight into what they are experiencing, or ability to express it in the event that they have insight. Other specified gender dysphoria or unspecified gender dysphoria can be diagnosed if a person does not meet the criteria for gender dysphoria but still has clinically significant distress or impairment. Intersex people are now included in the diagnosis of GD.
- Transsexualism (F64.0): Desire to live and be accepted as a member of the opposite sex, usually accompanied by a desire for surgery and hormonal treatment
- Gender identity disorder of childhood (F64.2): Persistent and intense distress about one's assigned gender, manifested prior to puberty
- Other gender identity disorders (F64.8)
- Gender identity disorder, unspecified (F64.9)
- Sexual maturation disorder (F66.0): Uncertainty about one's gender identity or sexual orientation, causing anxiety or distress
The ICD-11, which will come into effect on 1 January 2022, significantly revises classification of gender identity-related conditions. Under "conditions related to sexual health", the ICD-11 lists "gender incongruence", which is coded into three conditions:
- Gender incongruence of adolescence or adulthood (HA60): replaces F64.0
- Gender incongruence of childhood (HA61): replaces F64.2
- Gender incongruence, unspecified (HA6Z): replaces F64.9
In addition, sexual maturation disorder has been removed, along with dual-role transvestism. ICD-11 defines gender incongruence as "a marked and persistent incongruence between an individual’s experienced gender and the assigned sex", with no requirement for significant distress or impairment.
Treatment for a person diagnosed with GD may include psychotherapy or to support the individual's preferred gender through hormone therapy, gender expression and role, or surgery. This may include psychological counseling or physical changes resulting from medical interventions such as hormonal treatment, genital surgery, electrolysis or laser hair removal, chest/breast surgery, or other reconstructive surgeries. The goal of treatment may simply be to reduce problems resulting from the person's transgender status, for example, counseling the patient in order to reduce guilt associated with cross-dressing.
Guidelines have been established to aid clinicians. The World Professional Association for Transgender Health (WPATH) Standards of Care are used by some clinicians as treatment guidelines. Others use guidelines outlined in Gianna Israel and Donald Tarver's Transgender Care. Guidelines for treatment generally follow a "harm reduction" model.
The question of whether to counsel young children to be happy with their assigned sex, or to allow them to continue to exhibit behaviors that do not match their assigned sex—or to explore a gender transition—is controversial. Follow-up studies of children with gender dysphoria consistently show that the majority of them will not remain gender dysphoric after puberty and will instead identify as gay or lesbian. Factors that are associated with gender dysphoria persisting through puberty include intensity of gender dysphoria, amount of cross-gendered behavior, and verbal identification with the desired/experienced gender (i.e. stating that they are a different gender rather than wish to be a different gender).
Professionals who treat gender dysphoria in children sometimes prescribe drugs, known as puberty blockers, to delay the onset of puberty until a child is believed to be old enough to make an informed decision on whether hormonal or surgical gender reassignment is in their best interest. The use of puberty blockers for transgender children is controversial, however. In the UK, a high court ruling in the case of Bell v Tavistock found that it was "doubtful" that a child under 16 could understand and weigh the consequences of such a decision, and thus was unlikely to be able to give informed consent. Following the ruling, NHS England announced that children under 16 would no longer be given puberty blockers without court authorization. and a UK Department of Health commissioned review found that the quality of evidence for puberty blocker outcomes (for mental health, quality of life and impact on gender dysphoria) was very low certainty. In the United States, several states have introduced or are considering legislation that would prohibit the use of puberty blockers in the treatment of transgender children.
Until the 1970s, psychotherapy was the primary treatment for gender dysphoria and generally was directed to helping the person adjust to their assigned sex. Psychotherapy is any therapeutic interaction that aims to treat a psychological problem. Though some clinicians still use only psychotherapy to treat gender dysphoria, it may now be used in addition to biological interventions. Psychotherapeutic treatment of GD involves helping the patient to adapt to their gender incongruence or to explorative investigation of confounding co-occurring mental health issues. Attempts to alleviate GD by changing the patient's gender identity to reflect assigned sex have been ineffective.:1741 Severe mental disorders and general identity confusion are the context for the majority of adolescent-onset cases. Treating these psychiatric comorbidities first may be called for, before drawing conclusions regarding gender identity.
Biological treatments physically alter primary and secondary sex characteristics to reduce the discrepancy between an individual's physical body and gender identity. Biological treatments for GD are typically undertaken in conjunction with psychotherapy; however, the WPATH Standards of Care state that psychotherapy should not be an absolute requirement for biological treatments. It is known that some mental disorders are important to evaluate and treat before proceeding with hormones or surgery, as treatment of these mental disorders can sometimes make the wish for altering one's body disappear or significantly lessen.
Psychotherapy, hormone therapy, and sex reassignment surgery can be effective at treating GD when the WPATH Standards of Care are followed.:1570 However, a WPATH commissioned systematic review of the outcomes of hormone therapy concluded that the strength of the evidence for the association of hormone therapy with improvements in the quality of life, depression and anxiety is low due to methodological limitations of the studies undertaken. Gender-dysphoric patients who choose to undergo sex reassignment surgery report high levels of satisfaction.
For adolescents, much is unknown, including persistence. Disagreement among practitioners regarding treatment of adolescents is in part due to the lack of long-term data. Young people qualifying for biomedical treatment according to the Dutch model (including having GD from early childhood on which intensifies at puberty and absence of psychiatric comorbidities that could challenge diagnosis or treatment) found reduction in gender dysphoria, although limitations to these outcome studies have been noted, such as lack of controls or considering alternatives like psychotherapy.
“Most available evidence indicating positive outcomes for gender reassignment is of poor quality."More rigorous evaluations are needed to assess endocrine and surgical protocol effectiveness and safety. For instance, a 2020 Cochrane review found insufficient evidence to determine whether feminizing hormones were safe or effective. More research is needed to understand the potential harm of hormonal therapies. For surgery, studies are needed to examine the long-term psychological benefits (several have found significant long-term post-surgery psychological and psychiatric pathology, persistence of suicide attempts and suicide mortality were found in one of the few studies with robust methodology).
The DSM-5 estimates that about 0.005% to 0.014% of people assigned male at birth and 0.002% to 0.003% of people assigned female at birth are diagnosable with gender dysphoria.
According to Black's Medical Dictionary, gender dysphoria “occurs in one in 30,000 male births and one in 100,000 female births.” Studies in European countries in the early 2000s found that about 1 in 12,000 natal male adults and 1 in 30,000 natal female adults seek out sex reassignment surgery. Studies of hormonal treatment or legal name change find higher prevalence than sex reassignment, with, for example a 2010 Swedish study finding that 1 in 7750 adult natal males and 1 in 13120 adult natal females requested a legal name change to a name of the opposite gender.
Studies that measure transgender status by self-identification find even higher rates of gender identity different from sex assigned at birth (although some of those who identify as transgender or gender nonconforming may not experience clinically significant distress and so do not have gender dysphoria). A study in New Zealand found that 1 in 3630 natal males and 1 in 22714 natal females have changed their legal gender markers. A survey of Massachusetts adults found that 0.5% identify as transgender. A national survey in New Zealand of 8,500 randomly selected secondary school students from 91 randomly selected high schools found 1.2% of students responded "yes" to the question "Do you think you are transgender?". Outside of a clinical setting, the stability of transgender or non-binary identities is unknown.
Research indicates people who transition in adulthood are up to three times more likely to be male assigned at birth, but that among people transitioning in childhood the sex ratio is close to 1:1. The prevalence of gender dysphoria in children is unknown due to the absence of formal prevalence studies.
Neither the DSM-I (1952) nor the DSM-II (1968) contained a diagnosis analogous to gender dysphoria. Gender identity disorder first appeared as a diagnosis in the DSM-III (1980), where it appeared under "psychosexual disorders" but was used only for the childhood diagnosis. Adolescents and adults received a diagnosis of transsexualism (homosexual, heterosexual, or asexual type). The DSM-III-R (1987) added "Gender Identity Disorder of Adolescence and Adulthood, Non-Transsexual Type" (GIDAANT).
Society and culture
Researchers disagree about the nature of distress and impairment in people with GD. Some authors have suggested that people with GD suffer because they are stigmatized and victimized; and that, if society had less strict gender divisions, transgender people would suffer less.
Some controversy surrounds the creation of the GD diagnosis, with Davy et al. stating that although the creators of the diagnosis state that it has rigorous scientific support, "it is impossible to scrutinize such claims, since the discussions, methodological processes, and promised field trials of the diagnosis have not been published."
Some cultures have three defined genders: man, woman, and effeminate man. For example, in Samoa, the fa'afafine, a group of feminine males, are entirely socially accepted. The fa'afafine do not have any of the stigma or distress typically associated in most cultures with deviating from a male/female gender role. This suggests the distress so frequently associated with GD in a Western context is not caused by the disorder itself, but by difficulties encountered from social disapproval by one's culture. However, research has found that the anxiety associated with gender dysphoria persists in cultures, Eastern or otherwise, which are more accepting of gender nonconformity.
In Australia, a 2014 High Court of Australia judgment unanimously ruled in favor of a plaintiff named Norrie, who asked to be classified by a third gender category, 'non-specific', after a long court battle with the NSW Registrar of Births, Deaths and Marriages. However, the Court did not accept that gender was a social construction: it found that sex reassignment "surgery did not resolve her sexual ambiguity".:para 11
Classification as a disorder
The psychiatric diagnoses of gender identity disorder (now gender dysphoria) was introduced in DSM-III in 1980. Arlene Istar Lev and Deborah Rudacille have characterized the addition as a political maneuver to re-stigmatize homosexuality. (Homosexuality was removed from DSM-II in 1974.) By contrast, Kenneth Zucker and Robert Spitzer argue that gender identity disorder was included in DSM-III because it "met the generally accepted criteria used by the framers of DSM-III for inclusion." Some researchers, including Spitzer and Paul J. Fink, contend that the behaviors and experiences seen in transsexualism are abnormal and constitute a dysfunction. The American Psychiatric Association stated that gender nonconformity is not the same thing as gender dysphoria, and that "gender nonconformity is not in itself a mental disorder. The critical element of gender dysphoria is the presence of clinically significant distress associated with the condition."
Individuals with gender dysphoria may or may not regard their own cross-gender feelings and behaviors as a disorder. Advantages and disadvantages exist to classifying gender dysphoria as a disorder. Because gender dysphoria had been classified as a disorder in medical texts (such as the previous DSM manual, the DSM-IV-TR, under the name "gender identity disorder"), many insurance companies are willing to cover some of the expenses of sex reassignment therapy. Without the classification of gender dysphoria as a medical disorder, sex reassignment therapy may be viewed as a cosmetic treatment, rather than medically necessary treatment, and may not be covered. In the United States, transgender people are less likely than others to have health insurance, and often face hostility and insensitivity from healthcare providers.
The DSM-IV-TR diagnostic component of distress is not inherent in the cross-gender identity; rather, it is related to social rejection and discrimination suffered by the individual. Psychology professor Darryl Hill insists that gender dysphoria is not a mental disorder, but rather that the diagnostic criteria reflect psychological distress in children that occurs when parents and others have trouble relating to their child's gender variance. Transgender people have often been harassed, socially excluded, and subjected to discrimination, abuse and violence, including murder.
In December 2002, the British Lord Chancellor's office published a Government Policy Concerning Transsexual People document that categorically states, "What transsexualism is not ... It is not a mental illness." In May 2009, the government of France declared that a transsexual gender identity will no longer be classified as a psychiatric condition, but according to French trans rights organizations, beyond the impact of the announcement itself, nothing changed. Denmark made a similar statement in 2016.
In the ICD-11, GID is reclassified as "gender incongruence", a condition related to sexual health. The working group responsible for this recategorization recommended keeping such a diagnosis in ICD-11 to preserve access to health services.
- "Gender Dysphoria" (PDF). American Psychiatric Publishing. Retrieved December 24, 2016.
- Maddux JE, Winstead BA (2015). Psychopathology: Foundations for a Contemporary Understanding. Routledge. pp. 464–465. ISBN 978-1317697992.
- Coleman E (2011). "Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7" (PDF). International Journal of Transgenderism. Routledge Taylor & Francis Group. 13 (4): 165–232. doi:10.1080/15532739.2011.700873. S2CID 39664779. Archived from the original (PDF) on August 2, 2014. Retrieved August 30, 2014.
- Davidson, Michelle R. (2012). A Nurse's Guide to Women's Mental Health. Springer Publishing Company. p. 114. ISBN 978-0-8261-7113-9.
- American Psychiatric Association, DSM-5 Fact Sheets, Updated Disorders: Gender Dysphoria (Washington, D.C.: American Psychiatric Association, 2013): 2 ("DSM-5 aims to avoid stigma and ensure clinical care for individuals who see and feel themselves to be a different gender than their assigned gender. It replaces the diagnostic name 'gender identity disorder' with 'gender dysphoria', as well as makes other important clarifications in the criteria.").
- Russo J, Coker JK, King JH (2017). DSM-5® and Family Systems. Springer Publishing Company. p. 352. ISBN 978-0826183996.
People meeting criteria for Gender Dysphoria most often identify themselves as trans or transgender. Trans or transgender can be used as umbrella terms to include the broad spectrum of persons whose gender identity differs from the assigned gender (APA, 2013).
- Ranna Parekh. "What Is Gender Dysphoria?". American Psychiatric Publishing. Retrieved November 20, 2018.
- World Professional Association for Transgender Health (WPATH), Standards of Care for the Health of Transsexual, Transgender, and Gender Nonconforming People, ver. 7 (2011), 5 ("only some gender nonconforming people experience gender dysphoria at some point in their lives.")
- Heylens G, De Cuypere G, Zucker KJ, Schelfaut C, Elaut E, Vanden Bossche H, De Baere E, T'Sjoen G (March 2012). "Gender identity disorder in twins: a review of the case report literature". The Journal of Sexual Medicine. 9 (3): 751–7. doi:10.1111/j.1743-6109.2011.02567.x. PMID 22146048.
Of 23 monozygotic female and male twins, nine (39.1%) were concordant for GID; in contrast, none of the 21 same‐sex dizygotic female and male twins were concordant for GID, a statistically significant difference (P = 0.005)... These findings suggest a role for genetic factors in the development of GID.
- Diamond, Milton (2013). "Transsexuality Among Twins: Identity Concordance, Transition, Rearing, and Orientation". International Journal of Transgenderism. 14 (1): 24–38. doi:10.1080/15532739.2013.750222. S2CID 144330783.
Combining data from the present survey with those from past-published reports, 20% of all male and female monozygotic twin pairs were found concordant for transsexual identity... The responses of our twins relative to their rearing, along with our findings regarding some of their experiences during childhood and adolescence show their identity was much more influenced by their genetics than their rearing.
- Rosenthal, Stephen M. (2014-12-01). "Approach to the Patient: Transgender Youth: Endocrine Considerations". The Journal of Clinical Endocrinology & Metabolism. 99 (12): 4379–4389. doi:10.1210/jc.2014-1919. ISSN 0021-972X.
- Bryant, Karl (2018). "Gender Dysphoria". Encyclopædia Britannica Online. Retrieved August 16, 2018.
- Zucker, Kenneth J.; Lawrence, Anne A.; Kreukels, Baudewijntje P.C. (2016). "Gender Dysphoria in Adults". Annual Review of Clinical Psychology. 12: 217–247. doi:10.1146/annurev-clinpsy-021815-093034. PMID 26788901.
[For DSM-5] a reconceptualization was articulated in which 'identity' per se was not considered a sign of a mental disorder. Rather, it was the incongruence between one’s felt gender and assigned sex/gender (usually at birth) leading to distress and/or impairment that was the core feature of the diagnosis.
- Lev, Arlene Istar (2013). "Gender Dysphoria: Two Steps Forward, One Step Back". Clinical Social Work Journal. 41 (3): 288–296. doi:10.1007/s10615-013-0447-0. S2CID 144556484.
[Despite some misgivings], I think that the change in nomenclature from the DSM-IV to the DSM-5 is a step forward, that is, removing the concept of gender as the site of the disorder and placing the focus on issues of distress and dysphoria.
- Diagnostic and Statistical Manual of Mental Disorders (Fifth ed.). Arlington, VA: American Psychiatric Publishing. 2013. pp. 451–460. ISBN 978-0-89042-554-1.
- Guillamon A, Junque C, Gómez-Gil E (October 2016). "A Review of the Status of Brain Structure Research in Transsexualism". Archives of Sexual Behavior. 45 (7): 1615–48. doi:10.1007/s10508-016-0768-5. PMC 4987404. PMID 27255307.
- American Psychiatry Association (2013). Diagnostic and Statistical Manual of Mental Disorders (DSM-5) (5th ed.). Washington, DC and London: American Psychiatric Publishing. pp. 451–460. ISBN 978-0-89042-555-8.
- Diemer EW, Grant JD, Munn-Chernoff MA, Patterson DA, Duncan AE (August 2015). "Gender Identity, Sexual Orientation, and Eating-Related Pathology in a National Sample of College Students". The Journal of Adolescent Health. 57 (2): 144–9. doi:10.1016/j.jadohealth.2015.03.003. PMC 4545276. PMID 25937471.
- Harmon, A., & Oberleitner, M. G. (2016). Gender dysphoria. In Gale (Ed.), Gale encyclopedia of children's health: Infancy through adolescence (3rd ed.). Farmington, MI: Gale.
- Gijs, L; Brawaeys, A (2007). "Surgical Treatment of Gender Dysphoria in Adults and Adolescents: Recent Developments, Effectiveness, and Challenges". Annual Review of Sex Research. 18 (178–224).
- "Gender Dysphoria in Children". American Psychiatric Association. May 4, 2011. Retrieved July 3, 2011.
- "P 00 Gender Dysphoria in Children". American Psychiatric Association. Retrieved April 2, 2012.
- Davy, Zowie; Toze, Michael (2018). "What Is Gender Dysphoria? A Critical Systematic Narrative Review". Transgender Health. Mary Ann Liebert, Inc. Publishers. 3 (1): 159–169. doi:10.1089/trgh.2018.0014. PMC 6225591. PMID 30426079.
- "International Classification of Diseases (ICD) F64 Gender identity disorders". World Health Organization. Retrieved August 9, 2018.
- Potts, S; Bhugra, D (1995). "Classification of sexual disorders". International Review of Psychiatry. 7 (2): 167–174. doi:10.3109/09540269509028323.
- "International Classification of Diseases". World Health Organization. Retrieved August 11, 2018.
- "Gender incongruence (ICD-11)". icd.who.int. WHO. Retrieved August 28, 2018.
- Reed GM, Drescher J, Krueger RB, Atalla E, Cochran SD, First MB, Cohen-Kettenis PT, Arango-de Montis I, Parish SJ, Cottler S, Briken P, Saxena S (October 2016). "Disorders related to sexuality and gender identity in the ICD-11: revising the ICD-10 classification based on current scientific evidence, best clinical practices, and human rights considerations". World Psychiatry. 15 (3): 205–221. doi:10.1002/wps.20354. PMC 5032510. PMID 27717275.
- "NHS - Treatment - Gender dysphoria". NHS. 2016. Retrieved January 10, 2019.
- Leiblum, Sandra (2006). Principles and Practice of Sex Therapy, Fourth Edition. The Guilford Press. pp. 488–9. ISBN 978-1-59385-349-5.
- Heyes, C. J., & Latham, J. R. (2018). Trans surgeries and cosmetic surgeries: The politics of analogy. Transgender Studies Quarterly, 5(2), 174-189.
- Committee On Adolescence (July 2013). "Office-based care for lesbian, gay, bisexual, transgender, and questioning youth". Pediatrics. 132 (1): 198–203. doi:10.1542/peds.2013-1282. PMID 23796746.
However, adolescents with multiple or anonymous partners, having unprotected intercourse, or having substance abuse issues should be tested at shorter intervals.
- "www.glma.org Compendium of Health Profession Association LGBT Policy & Position Statements" (PDF). GLMA. 2013. Retrieved August 27, 2013.
- "APA Policy Statements on Lesbian, Gay, Bisexual, & Transgender Concerns" (PDF). American Psychological Association. 2011. Retrieved August 27, 2013.
BE IT FURTHER RESOLVED that APA recognizes the efficacy, benefit, and necessity of gender transition treatments for appropriately evaluated individuals and calls upon public and private insurers to cover these medically necessary treatments;
- Wallien, M. S. C., & Cohen-Kettenis, P. T. (2008). Psychosexual outcome of gender-dysphoric children. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 1413–1423.
- Drummond, K. D., Bradley, S. J., Badali-Peterson, M., & Zucker, K. J. (2008). A follow-up study of girls with gender identity disorder. Developmental Psychology, 44, 34–45.
- Steensma, T. D., McGuire, J. K., Kreukels, B. P. C., Beekman, A. J., & Cohen-Kettenis, P. T. (2013). Factors associated with desistence and persistence of childhood gender dysphoria: A quantitative follow-up study. Journal of the American Academy of Child and Adolescent Psychiatry, 52, 582–590.
- Ristori, Jiska; Steensma, Thomas D. (2 January 2016). "Gender dysphoria in childhood". International Review of Psychiatry. 28 (1): 13–20. doi:10.3109/09540261.2015.1115754. PMID 26754056. S2CID 5461482.
- The Transgendered Child: A Handbook for Families and Professionals (Brill and Pepper, 2008)[full citation needed][page needed]
- Alleyne, Richard (15 April 2011). "Puberty blocker for children considering sex change". The Telegraph. Retrieved 1 December 2020.
- "Quincy Bell and A v. Tavistock and Portman NHS Foundation Trust" (PDF). Retrieved 4 December 2020.
- "Puberty blockers: Under-16s 'unlikely' to be able to give informed consent". BBC News. 1 December 2020. Retrieved 4 December 2020.
- Woode, David (1 December 2020). "Children under 16 will no longer be given puberty blockers without court authorisation". inews.co.uk. Retrieved 4 December 2020.
- "Evidence review: Gonadotrophin releasing hormone analogues for children and adolescents with gender dysphoria". Retrieved 2 April 2021.
The critical outcomes for decision making are the impact on gender dysphoria, mental health and quality of life. The quality of evidence for these outcomes was assessed as very low certainty using modified GRADE.
- Safer, Joshua D. (17 February 2020). "Controversial pubertal blocker legislation may bring unintended consequences for children". Healio. Retrieved 15 December 2020.
- Kaltiala-Heino, Riittakerttu; Sumia, Maria; Työläjärvi, Marja; Lindberg, Nina (2015). "Two years of gender identity service for minors: overrepresentation of natal girls with severe problems in adolescent development". Child and Adolescent Psychiatry and Mental Health. 9: 9. doi:10.1186/s13034-015-0042-y. ISSN 1753-2000. PMC 4396787. PMID 25873995.
"for the majority of adolescent-onset cases, GD presented in the context of severe mental disorders and general identity confusion. In such situations, appropriate treatment for psychiatric comorbidities may be warranted before conclusions regarding gender identity can be drawn.","There is still no clear consensus regarding hormonal treatment for adolescents because long-term data are unavailable;","In a nationwide long-term follow-up study of adult cases, psychiatric morbidity, suicide attempts and suicide mortality persisted as elevated after juridical and medical SR.
- Swedish National Board of Health and Welfare (Feb 2020). "Development of the diagnosis gender dysphoria (Swedish)" (PDF). socialstyrelsen.se. Retrieved 13 March 2021.
- Kozlowska, Kasia; Chudleigh, Catherine; McClure, Georgia; Maguire, Ann M.; Ambler, Geoffrey R. (2021-01-12). "Attachment Patterns in Children and Adolescents With Gender Dysphoria". Frontiers in Psychology. 11: 582688. doi:10.3389/fpsyg.2020.582688. ISSN 1664-1078.
- D’Angelo, Roberto; Syrulnik, Ema; Ayad, Sasha; Marchiano, Lisa; Kenny, Dianna Theadora; Clarke, Patrick (2021-01-01). "One Size Does Not Fit All: In Support of Psychotherapy for Gender Dysphoria". Archives of Sexual Behavior. 50 (1): 7–16. doi:10.1007/s10508-020-01844-2. ISSN 1573-2800. PMC 7878242. PMID 33089441.
- George R. Brown, MD (July 20, 2011). "Chapter 165 Sexuality and Sexual Disorders". In Robert S. Porter, MD; et al. (eds.). The Merck Manual of Diagnosis and Therapy (19th ed.). Whitehouse Station, NJ, USA: Merck & Co., Inc. pp. 1740–1747. ISBN 978-0-911910-19-3.
- Bockting, W; Knudson, G; Goldberg, J (January 2006). "Counselling and Mental Health Care of Transgender Adults and Loved Ones". International Journal of Transgenderism. 9: 35–82. doi:10.1300/J485v09n03_03.
"As per Figure 1, delusions about sex or gender, dissociative disorders, thought disorders,or obsessive or compulsive features should be evaluated and treated prior to proceeding with hormone therapy or surgery. Thought disorders, dissociative disorders, and obsessive-compulsive disorders can, rarely, cause a transient wish for sex reassignment which disappears or significantly lessens when the underlying mental health condition is treated. It is important to treat these disorders before proceeding with hormones or surgery to ensure that the desire for alteration of primary or secondary sex characteristics is not a temporary desire." See also WPATH Standards of Care, version 7, page 23:“The role of mental health professionals includes making reasonably sure that the gender dysphoria is not secondary to or better accounted for by other diagnoses.” And the paradigmatic Dutch model for consideration of comorbid conditions before proceeding with treatment for childhood onset.
- "Standards of Care for the Health of Transsexual, Transgender, and Gender Nonconforming People" (PDF). World Professional Association for Transgender Health. pp. 28–29. Retrieved 15 March 2021.
- "Hormone Therapy, Mental Health, and Quality of Life Among Transgender People: A Systematic Review". Journal of the Endocrine Society.
This systematic review of 20 studies found evidence that gender-affirming hormone therapy may be associated with improvements in QOL scores and decreases in depression and anxiety symptoms among transgender people. Associations were similar across gender identity and age. The strength of evidence for these conclusions is low due to methodological limitations.
- Carroll, Richard A. (September 1999). "Outcomes of Treatment for Gender Dysphoria". Journal of Sex Education and Therapy. 24 (3): 128–136. doi:10.1080/01614576.1999.11074292.
- Cohen-Kettenis, Peggy T.; Delemarre-van de Waal, Henriette A.; Gooren, Louis J. G. (2008). "The treatment of adolescent transsexuals: changing insights". The Journal of Sexual Medicine. 5 (8): 1892–1897. doi:10.1111/j.1743-6109.2008.00870.x. ISSN 1743-6109. PMID 18564158.
- de Vries, Annelou L. C.; McGuire, Jenifer K.; Steensma, Thomas D.; Wagenaar, Eva C. F.; Doreleijers, Theo A. H.; Cohen-Kettenis, Peggy T. (2014). "Young adult psychological outcome after puberty suppression and gender reassignment". Pediatrics. 134 (4): 696–704. doi:10.1542/peds.2013-2958. ISSN 1098-4275. PMID 25201798.
- Zucker, Kenneth J. (2019-10-01). "Adolescents with Gender Dysphoria: Reflections on Some Contemporary Clinical and Research Issues". Archives of Sexual Behavior. 48 (7): 1983–1992. doi:10.1007/s10508-019-01518-8. ISSN 1573-2800.
In the Dutch model, several factors were identified in deeming adolescent eligibility for early biomedical treatment. According to Cohen-Kettenis, Delemarre-van de Waal, and Gooren (2008), these included the following: (1) the presence of gender dysphoria from early childhood on; (2) an exacerbation of the gender dysphoria after the first signs of puberty; (3) the absence of psychiatric comorbidity that would interfere with a diagnostic evaluation or treatment; (4) adequate psychological and social support during treatment; and (5) a demonstration of knowledge of the sex/gender reassignment process. Several studies have reported on the benefits of this therapeutic protocol in reducing gender dysphoria (e.g., de Vries et al., 2014, which is the best study to date). Of course, one should bear in mind some of the limitation to these outcome studies, including the fact that not all assessed adolescents were deemed eligible for the treatment protocol (and thus we know relatively little about the longer-term outcomes of these youth) and that study designs have not included alternative treatment options (such as psychosocial therapy) or even being assigned to a wait-list control condition;
- D’Angelo, Roberto (2018-10-01). "Psychiatry's ethical involvement in gender-affirming care". Australasian Psychiatry. 26 (5): 460–463. doi:10.1177/1039856218775216. ISSN 1039-8562.
Most available evidence indicating positive outcomes for gender reassignment is of poor quality. The few studies with robust methodology suggest that some patients have poor outcomes and may be at risk of suicide.
- Hembree, Wylie C; Cohen-Kettenis, Peggy T; Gooren, Louis; Hannema, Sabine E; Meyer, Walter J; Murad, M Hassan; Rosenthal, Stephen M; Safer, Joshua D; Tangpricha, Vin; T’Sjoen, Guy G (2017-11-01). "Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society* Clinical Practice Guideline". The Journal of Clinical Endocrinology & Metabolism. 102 (11): 3869–3903. doi:10.1210/jc.2017-01658. ISSN 0021-972X.
“In the future, we need more rigorous evaluations of the effectiveness and safety of endocrine and surgical protocols. Specifically, endocrine treatment protocols for GD/gender incongruence should include the careful assessment of the following: (1) the effects of prolonged delay of puberty in adolescents on bone health, gonadal function, and the brain (including effects on cognitive, emotional, social, and sexual development); [...] and (4) the risks and benefits of gender-affirming hormone treatment in older transgender people.”“Future research is needed to ascertain the potential harm of hormonal therapies (176).” “Owing to the lack of controlled studies, incomplete follow-up, and lack of valid assessment measures, evaluating various surgical approaches and techniques is difficult." "Several postoperative studies report significant long-term psychological and psychiatric pathology (259–261).” "We need more studies with appropriate controls that examine long-term quality of life, psychosocial outcomes, and psychiatric outcomes to determine the long-term benefits of surgical treatment.”
- Haupt, Claudia; Henke, Miriam; Kutschmar, Alexia; Hauser, Birgit; Baldinger, Sandra; Saenz, Sarah Rafaela; Schreiber, Gerhard (2020-11-28). "Antiandrogen or estradiol treatment or both during hormone therapy in transitioning transgender women". Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd013138.pub2. ISSN 1465-1858.
We found insufficient evidence to determine the efficacy or safety of hormonal treatment approaches for transgender women in transition."
- Diagnostic and Statistical Manual of Mental Disorders 5. American Psychiatric Association. 2013. p. 454. ISBN 978-0-89042-555-8.
- Gender Identity Disorders. in Harvey Marcovitch, ed. Black's Medical Dictionary, 43rd edition, New York: Bloomsbury, 2018
- Zucker, Kenneth J. (2017). "Epidemiology of gender dysphoria and transgender identity". Sexual Health. 14 (5): 404. doi:10.1071/SH17067. ISSN 1448-5028.
- Conron, KJ; Scott, G; Stowell, GS; Landers, S (January 2012), "Transgender Health in Massachusetts: Results from a Household Probability Sample of Adults", American Journal of Public Health, American Public Health Association, 102 (1): 118–222, doi:10.2105/AJPH.2011.300315, ISSN 1541-0048, OCLC 01642844, PMC 3490554, PMID 22095354,
Between 2007 and 2009, survey participants aged 18 to 64 years in the Massachusetts Behavioral Risk Factor Surveillance System (MA-BRFSS; N = 28 662) were asked: "Some people describe themselves as transgender when they experience a different gender identity from their sex at birth. For example, a person born into a male body, but who feels female or lives as a woman. Do you consider yourself to be transgender?" […] We restricted the analytic sample to 28176 participants who answered yes or no to the transgender question (excluding n=364, 1.0% weighted who declined to respond. […] Transgender respondents (n=131; 0.5%; 95% confidence interval [CI]=0.3%, 0.6%) were somewhat younger and more likely to be Hispanic than were nontransgender respondents.
- Clark TC, Lucassen MF, Bullen P, Denny SJ, Fleming TM, Robinson EM, Rossen FV (July 2014). "The health and well-being of transgender high school students: results from the New Zealand adolescent health survey (Youth'12)". The Journal of Adolescent Health. 55 (1): 93–9. doi:10.1016/j.jadohealth.2013.11.008. PMID 24438852.
Whether a student was transgender was measured by the question, "Do you think you are transgender? This is a girl who feels like she should have been a boy, or a boy who feels like he should have been a girl (e.g., Trans, Queen, Fa’faffine, Whakawahine, Tangata ira Tane, Genderqueer)?" […] Over 8,000 students (n = 8,166) answered the question about whether they were transgender. Approximately 95% of students did not report being transgender (n=7,731; 94.7%), 96 students reported being transgender (1.2%), 202 reported not being sure (2.5%), and 137 did not understand the question (1.7%).
- Landén M, Wålinder J, Lundström B (April 1996). "Prevalence, incidence and sex ratio of transsexualism". Acta Psychiatrica Scandinavica. 93 (4): 221–3. doi:10.1111/j.1600-0447.1996.tb10638.x. PMID 8712018. S2CID 26661088.
On average, the male [to female]:female [to male] ratio in prevalence studies is estimated to be 3:1. However […] the incidence studies have shown a considerably lower male [to female] predominance. In Sweden and England and Wales, a sex ratio of 1:1 has been reported. In the most recent incidence data from Sweden, there is a slight male [to female] predominance among the group consisting of all applicants for sex reassignment, while in the group of primary [early onset] transsexuals there is no difference in incidence between men and women.
- Koh J (2012). "[The history of the concept of gender identity disorder]". Seishin Shinkeigaku Zasshi = Psychiatria et Neurologia Japonica. 114 (6): 673–80. PMID 22844818.
- Pauly, Ira B. (1993). "Terminology and Classification of Gender Identity Disorders". Journal of Psychology & Human Sexuality. 5 (4): 1–14. doi:10.1300/J056v05n04_01.
- Drescher, Jack, Transsexualism, Gender Identity Disorder and the DSM, Journal of Gay & Lesbian Mental Health 14, no. 2 (2010): 112.
- Bryant, Karl Edward (2007). The Politics of Pathology and the Making of Gender Identity Disorder. Ann Arbor, Michigan. p. 222. ISBN 978-0-549-26816-1.
- Giordano, Simona (2012). Children with Gender Identity Disorder: A Clinical, Ethical, and Legal Analysis. New Jersey: Routledge. p. 147. ISBN 978-0-415-50271-9.
- Vasey PL, Bartlett NH (2007). "What can the Samoan "Fa'afafine" teach us about the Western concept of gender identity disorder in childhood?". Perspectives in Biology and Medicine. 50 (4): 481–90. doi:10.1353/pbm.2007.0056. PMID 17951883. S2CID 37437172.
- Diagnostic and Statistical Manual of Mental Disorders 5. American Psychiatric Association. 2013. p. 459. ISBN 978-0-89042-555-8.
- NSW Registrar of Births, Deaths and Marriages v Norrie  HCA 11 (2 April 2014), High Court (Australia).
- Lev, Arlene Istar (2004). Transgender Emergence: Therapeutic Guidelines for Working with Gender-Variant People and Their Families. Haworth Press. p. 172. ISBN 978-0-7890-2117-5.
- Rudacille, Deborah (February 2005). The Riddle of Gender: Science, Activism, and Transgender Rights. Pantheon. ISBN 978-0-375-42162-4.[page needed]
- Zucker, KJ; Spitzer, RL (Jan–Feb 2005), "Was the gender identity disorder of childhood diagnosis introduced into DSM-III as a backdoor maneuver to replace homosexuality? A historical note.", Journal of Sex and Marital Therapy, 31 (1): 31–42, doi:10.1080/00926230590475251, PMID 15841704, S2CID 22589255
- "Controversy Continues to Grow Over DSM's GID Diagnosis". Psychiatric News.
- Ford, Zack. "APA Revises Manual: Being Transgender is No Longer a Mental Disorder". Archived from the original on February 2, 2013. Retrieved April 7, 2013.
- Mallon, Gerald P. (2009). Social Work Practice with Transgender and Gender Variant Youth. New Jersey: Routledge. ISBN 978-0-415-99482-8.
- "Government Policy concerning Transsexual People". People's rights/Transsexual people. U.K. Department for Constitutional Affairs. 2003. Archived from the original on May 11, 2008.
- "La transsexualité ne sera plus classée comme affectation psychiatrique". Le Monde. May 16, 2009.
- "La France est très en retard dans la prise en charge des transsexuels". Libération (in French). May 17, 2011.
En réalité, ce décret n'a été rien d'autre qu'un coup médiatique, un très bel effet d'annonce. Sur le terrain, rien n'a changé.
- "Denmark will become first country to no longer define being transgender as a mental illness". The Independent. May 14, 2016.
- Conway, Lynn (June 26, 2014). "Successful TransMen: Links and Photos". ai.eecs.umich.edu. Retrieved December 2, 2014.
- Conway, Lynn (February 5, 2011). "Transsexual Women's Successes: Links and Photos". ai.eecs.umich.edu. Retrieved December 2, 2014.
- Jacques, Juliet. "A Transgender Journey". The Guardian. Retrieved December 2, 2014.
- Sharp, Victoria Madeleine; Lewis, Clive Buckland; Lieven, Natalie Marie Daniella. "Bell v Tavistock" (PDF). In the High Court of Justice Administrative Court Divisional Court ( EWHC 3274 (Admin)): CO/60/2020.
- World Professional Association for Transgender Health (2012). Standards of Care for Gender Identity Disorders (PDF). Harry Benjamin International Gender Dysphoria Association. Archived from the original (PDF) on September 24, 2014. Includes a description of ICD-10 criteria.
- Health Law Standards of Care for Transsexualism – An alternative to the Benjamin Standards of Care proposed by the International Conference on Transgender Law and Employment Policy.
- The Lord Chancellor's Department Government Policy concerning Transsexual People