In multivariate behavioral & quantitative genetics, a genetic correlation (denoted or ) is the proportion of variance that two traits share due to genetic causes, the correlation between the genetic influences on a trait and the genetic influences on a different trait estimating the degree of pleiotropy or causal overlap. A genetic correlation of 0 implies that the genetic effects on one trait are independent of the other, while a correlation of 1 implies that all of the genetic influences on the two traits are identical. The bivariate genetic correlation can be generalized to inferring genetic latent variable factors across >2 traits using factor analysis. Genetic correlation models were introduced into behavioral genetics in the 1970s-1980s.
Genetic correlations have applications in validation of GWAS results, breeding, prediction of traits, and discovering the etiology of traits & diseases.
They can be estimated using twin studies and molecular genetics. Genetic correlations have been found to be common in non-human genetics and to be broadly similar to their respective phenotypic correlations, and also found extensively in human traits.
This finding of widespread pleiotropy has implications for artificial selection in agriculture, interpretation of phenotypic correlations, social inequality, attempts to use Mendelian randomization in causal inference, the understanding of the biological origins of complex traits, and the design of GWASes.
A genetic correlations is to be contrasted with environment correlations between the environments affecting two traits (e.g. if poor nutrition in a household caused both lower IQ and height); a genetic correlation between two traits can contribute to the observed (phenotypic) correlation between two traits, but genetic correlations can also be opposite observed phenotypic correlations if the environment correlation is sufficiently strong in the other direction, perhaps due to tradeoffs or specialization; for example, in the UK Biobank, of 118 continuous human traits, 29% of their intercorrelations have opposite signs between environmental & genetic correlations.
- 1 Interpretation
- 2 Cause
- 3 Uses
- 4 Computing the genetic correlation
- 5 Correlations
- 6 See also
- 7 References
- 8 External links
Genetic correlations are not the same as heritability, as it is about the overlap between the two sets of influences and not their absolute magnitude; two traits could be both highly heritable but not be genetically correlated or have small heritabilities and be completely correlated (as long as the heritabilities are non-zero).
For example, consider two traits - dark skin and black hair. These two traits may individually have a very high heritability (most of the population-level variation in the trait due to genetic differences, or in simpler terms, genetics contributes significantly to these two traits), however, they may still have a very low genetic correlation if, for instance, these two traits were being controlled by different, non-overlapping, non-linked genetic loci.
A genetic correlation between two traits will tend to produce phenotypic correlations - e.g. the genetic correlation between intelligence and SES or education and family SES implies that intelligence/SES will also correlate phenotypically. The phenotypic correlation will be limited by the degree of genetic correlation and also by the heritability of each trait. The expected phenotypic correlation is the bivariate heritability' and can be calculated as the square roots of the heritabilities multiplied by the genetic correlation. (Using a Plomin example, for two traits with heritabilities of 0.60 & 0.23, , and phenotypic correlation of r=0.45 the bivariate heritability would be , so of the observed phenotypic correlation, 0.28/0.45 = 62% of it is due to genetics.)
Genetic correlations can arise due to:
- linkage disequilibrium (two neighboring genes tend to be inherited together, each affecting a different trait)
- biological pleiotropy (a single gene having multiple otherwise unrelated biological effects, or shared regulation of multiple genes)
- mediated pleiotropy (a gene causes trait X and trait X causes trait Y).
- biases: population stratification such as ancestry or assortative mating (sometimes called "gametic phase disequilibrium"), spurious stratification such as ascertainment bias/self-selection or Berkson's paradox, or misclassification of diagnoses
Causes of changes in traits
Genetic correlations are scientifically useful because genetic correlations can be analyzed over time within an individual longitudinally (e.g. intelligence is stable over a lifetime, due to the same genetic influences - childhood genetically correlates with old age), or across studies or populations or ethnic groups/races, or across diagnoses, allowing discovery of whether different genes influence a trait over a lifetime (typically, they do not), whether different genes influence a trait in different populations due to differing local environments, whether there is disease heterogeneity across times or places or sex (particularly in psychiatric diagnoses there is uncertainty whether 1 country's 'autism' or 'schizophrenia' is the same as another's or whether diagnostic categories have shifted over time/place leading to different levels of ascertainment bias), and to what degree traits like autoimmune or psychiatric disorders or cognitive functioning meaningfully cluster due sharing a biological basis and genetic architecture (for example, reading & mathematics disability genetically correlate, consistent with the Generalist Genes Hypothesis, and these genetic correlations explain the observed phenotypic correlations or 'co-morbidity'; IQ and specific measures of cognitive performance such as verbal, spatial, and memory tasks, reaction time, long-term memory, executive function etc. all show high genetic correlations as do neuroanatomical measurements, and the correlations may increase with age, with implications for the etiology & nature of intelligence). This can be an important constraint on conceptualizations of the two traits: traits which seem different phenotypically but which share a common genetic basis require an explanation for how these genes can influence both traits.
Genetic correlations can be used in GWASes by using polygenic scores or genome-wide hits for one (often more easily measured) trait to increase the prior probability of variants for a second trait; for example, since intelligence and years of education are highly genetically correlated, a GWAS for education will inherently also be a GWAS for intelligence and be able to predict variance in intelligence as well and the strongest SNP candidates can be used to increase the statistical power of a smaller GWAS, a combined analysis on the latent trait done where each measured genetically-correlated trait helps reduce measurement error and boosts the GWAS's power considerably (e.g. Krapohl et al. 2017, using elastic net and multiple polygenic scores, improving intelligence prediction from 3.6% of variance to 4.8%; Hill et al. 2017b uses MTAG to combine 3 g-loaded traits of education, household income, and a cognitive test score to find 107 hits & doubles predictive power of intelligence) or one could do a GWAS for multiple traits jointly.
Genetic correlations can also quantify the contribution of correlations <1 across datasets which might create a false "missing heritability", by estimating the extent to which differing measurement methods, racial influences, or environments create only partially overlapping sets of relevant genetic variants.
Hairless dogs have imperfect teeth; long-haired and coarse-haired animals are apt to have, as is asserted, long or many horns; pigeons with feathered feet have skin between their outer toes; pigeons with short beaks have small feet, and those with long beaks large feet. Hence if man goes on selecting, and thus augmenting any peculiarity, he will almost certainly modify unintentionally other parts of the structure, owing to the mysterious laws of correlation.
Genetic correlations are also useful in applied contexts such as plant/animal breeding by allowing substitution of more easily measured but highly genetically correlated characteristics (particularly in the case of sex-linked or binary traits under the liability-threshold model, where differences in the phenotype can rarely be observed but another highly correlated measure, perhaps an endophenotype, is available in all individuals), compensating for different environments than the breeding was carried out in, making more accurate predictions of breeding value using the multivariate breeder's equation as compared to predictions based on the univariate breeder's equation using only per-trait heritability & assuming independence of traits, and avoiding unexpected consequences by taking into consideration that artificial selection for/against trait X will also increase/decrease all traits which positively/negatively correlate with X. The limits to selection set by the inter-correlation of traits, and the possibility for genetic correlations to change over long-term breeding programs, lead to Haldane's dilemma limiting the intensity of selection and thus progress.
Breeding experiments on genetically correlated traits can measure the extent to which correlated traits are inherently developmentally linked & response is constrained, and which can be dissociated. Some traits, such as the size of eyespots on the butterfly Bicyclus anynana can be dissociated in breeding, but other pairs, such as eyespot colors, have resisted efforts.
Computing the genetic correlation
Genetic correlations require a genetically informative sample. They can be estimated by using breeding experiments on two traits of known heritability and selecting on one trait to measure the change in the other trait (allowing inferring the genetic correlation), family/adoption/twin studies (analyzed using SEMs or DeFries-Fulker extremes analysis), molecular estimation of relatedness such as GCTA, methods employing polygenic scores like LD score regression, BOLT-REML, CPBayes, or HESS, comparison of genome-wide SNP hits in GWASes (as a loose lower bound), and phenotypic correlations of populations with at least some related individuals. (As with estimating SNP heritability, the better computational scaling & the ability to estimate only using public polygenic scores is a particular advantage for LD score regression over competing methods, and combined with the increasing availability of polygenic scores from datasets like the UK Biobank has led to an explosion of genetic correlation research in the 2010s.) The methods are related to Haseman-Elston regression & PCGC regression. Such methods are typically genome-wide, but it is also possible to estimate genetic correlations for specific variants or genome regions.
One way to consider it is using trait X in twin 1 to predict trait Y in twin 2 for monozygotic and dizygotic twins (i.e. using twin 1's IQ to predict twin 2's brain volume); if this cross-correlation is larger for the more genetically-similar monozygotic twins than for the dizygotic twins, the similarity indicates that the traits are not genetically independent and there is some common genetics influencing both IQ and brain volume. (Statistical power can be boosted by using siblings as well.)
Genetic correlations are affected by methodological concerns; underestimation of heritability, such as due to assortative mating, will lead to overestimates of longitudinal genetic correlation, and moderate levels of misdiagnoses can create pseudo correlations. As they are affected by heritabilities of both traits, genetic correlations have low statistical power, especially in the presence of measurement errors biasing heritability downwards, because "estimates of genetic correlations are usually subject to rather large sampling errors and therefore seldom very precise": the standard error of an estimate is . (Larger genetic correlations & heritabilities will be estimated more precisely.) However, inclusion of genetic correlations in an analysis of a pleiotropic trait can boost power for the same reason that multivariate regressions are more powerful than separate univariate regressions.
Twin methods have the advantage of being usable without detailed biological data, with human genetic correlations calculated as far back as the 1970s and animal/plant genetic correlations calculated in the 1930s, and require sample sizes in the hundreds for being well-powered, but they have the disadvantage of making assumptions which have been criticized, and in the case of rare traits like anorexia nervosa it may be difficult to find enough twins with a diagnosis to make meaningful cross-twin comparisons, and can only be estimated with access to the twin data; molecular genetic methods like GCTA or LD score regression have the advantage of not requiring specific degrees of relatedness and so can easily study rare traits using case-control designs, which also reduces the number of assumptions they rely on, but those methods could not be run until recently, require large sample sizes in the thousands or hundreds of thousands (to obtain precise SNP heritability estimates, see the standard error formula), may require individual-level genetic data (in the case of GCTA but not LD score regression)
Given a genetic covariance matrix, the genetic correlation is computed by standardizing this, i.e., by converting the covariance matrix to a correlation matrix. For example, if two traits, say height and weight have the following additive genetic variance-covariance matrix:
Then the genetic correlation is .55, as seen is the standardized matrix below:
In practice, structural equation modeling applications such as Mx or OpenMx (and before that, historically, LISREL) are used to calculate both the genetic covariance matrix and its standardized form. In R, cov2cor() will standardize the matrix.
Typically, published reports will provide genetic variance components that have been standardized as a proportion of total variance (for instance in an ACE twin study model standardised as a proportion of V-total = A+C+E). In this case, the metric for computing the genetic covariance (the variance within the genetic covariance matrix) is lost (because of the standardizing process), so you cannot readily estimate the genetic correlation of two traits from such published models. Multivariate models (such as the Cholesky decomposition[better source needed]) will, however, allow the viewer to see shared genetic effects (as opposed to the genetic correlation) by following path rules. It is important therefore to provide the unstandardised path coefficients in publications.
This list (which may have dates, numbers, etc.) may be better in a sortable table format. (October 2016)
Genetic correlations, both positive and negative, have been measured for a wide variety of human traits using primarily molecular genetic methods but also, historically, twins. Below are genetic correlations which have been reported in the literature as statistically significant (direction is not indicated but generally diseases positively correlate with other diseases and negatively correlate with traits like intelligence).
- Gene-environment correlation
- Heritability of intelligence; g factor (psychometrics)
- Cognitive epidemiology
- Lothian birth-cohort studies
- Mendelian randomization
- Falconer 1960
- Neale & Maes 1996, Methodology for genetics studies of twins and families (6th ed.). Dordrecht, The Netherlands: Kluwer.
- pg 123 of Plomin 2012
- pg194-195 of Jensen 1980, Bias in Mental Testing
- Martin & Eaves 1977, "The Genetical Analysis of Covariance Structure"
- Eaves et al 1978, "Model-fitting approaches to the analysis of human behaviour"
- Loehlin & Vandenberg 1968, "Genetic and environmental components in the covariation of cognitive abilities: An additive model", in Progress in Human Behaviour Genetics, ed. S. G. Vandenberg, pp. 261-278. Johns Hopkins, Baltimore.
- Purcell 2002, "Variance components models for gene-environment interaction in twin analysis"
- Kohler et al 2011, "Social Science Methods for Twins Data: Integrating Causality, Endowments and Heritability"
- Wagner & Zhang 2011, "The pleiotropic structure of the genotype-phenotype map: The evolvability of complex organisms"
- Cheverud 1988, "A comparison of genetic and phenotypic correlations"
- Krapohl et al 2015, "Phenome-wide analysis of genome-wide polygenic scores"
- Hagenaars et al 2016, "Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia"
- Hill et al 2016, "Molecular genetic contributions to social deprivation and household income in UK Biobank (n=112,151)"
- "LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis", Zheng et al 2016
- Sivakumaran et al 2011, "Abundant pleiotropy in human complex diseases and traits"
- Solovieff et al 2013, "Pleiotropy in complex traits: challenges and strategies"
- Cotsapas et al 2011, "Pervasive sharing of genetic effects in autoimmune disease"
- Chambers et al 2011, "Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma"
- Hemani et al 2017, "Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome"
- Canela-Xandri et al 2017, "An atlas of genetic associations in UK Biobank"
- Mottus et al 2017, "Markers of Psychological Differences and Social and Health Inequalities: Possible Genetic and Phenotypic Overlaps"
- Pickrell 2015, "Fulfilling the promise of Mendelian randomization"
- Smith 2015, "Mendelian randomization: a premature burial?"; "Understanding Mendelian Randomization"
- Burgess et al 2016, "Beyond Mendelian randomization: how to interpret evidence of shared genetic predictors"
- Hagenaars et al 2016b, "Cognitive ability and physical health: a Mendelian randomization study"
- Bowden et al 2015, "Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression"
- Verbanck et al 2017, "Widespread pleiotropy confounds causal relationships between complex traits and diseases inferred from Mendelian randomization"
- eg Falconer cites the example of chicken size and egg laying: chickens grown large for genetic reasons lay later, fewer, and larger eggs, while chickens grown large for environmental reasons lay quicker and more but normal sized eggs (pg315 of Falconer 1960); Falconer in Table 19.1 on pg316 also provides examples of opposite-signed phenotypic & genetic correlations: fleece-weight/length-of-wool & fleece weight/body-weight in sheep, and body-weight/egg-timing & body-weight/egg-production in chicken. One consequence of the negative chicken correlations was that, despite moderate heritabilities and a positive phenotypic correlation, selection had begun to fail to yield any improvements (pg329) according to "Genetic slippage in response to selection for multiple objectives", Dickerson 1955.
- Kruuk, Loeske E. B.; Slate, Jon; Pemberton, Josephine M.; Brotherstone, Sue; Guinness, Fiona; Clutton-Brock, Tim (2002). "Antler Size in Red Deer: Heritability and Selection but No Evolution" (PDF). Evolution. 56 (8): 1683–95. doi:10.1111/j.0014-3820.2002.tb01480.x. PMID 12353761.
- Krapohl & Plomin 2016, "Genetic link between family socioeconomic status and children's educational achievement estimated from genome-wide SNPs"
- pg 397 of Plomin et al 2012
- Tong et al 2017, "Shared regulatory sites are abundant in the human genome and shed light on genome evolution and disease pleiotropy"
- Munafo et al 2016, "Collider Scope: How selection bias can induce spurious associations"
- Hewitt et al 1988, "Resolving the causes of developmental continuity or 'tracking.' I. Longitudinal twin studies during growth"
- Deary et al 2012, "Genetic contributions to stability and change in intelligence from childhood to old age"
- "The substantial comorbidity between specific cognitive disabilities is largely due to genetic factors, meaning that the same genes affect different learning disabilities although there are also disability-specific genes." pg184-185 of Plomin et al 2012
- Rietveld et al 2013, "GWAS of 126,559 individuals identifies genetic variants associated with educational attainment"
- Rietveld et al 2014, "Common genetic variants associated with cognitive performance identified using the proxy-phenotype method"
- Krapohl et al 2017, "Multi-polygenic score approach to trait prediction"
- Hill et al 2017b, "A combined analysis of genetically correlated traits identifies 107 loci associated with intelligence"
- Turley et al 2017, "MTAG: Multi-Trait Analysis of GWAS"
- Andreassen et al 2013, "Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate"
- Porter & O'Reilly, "Multivariate simulation framework reveals performance of multi-trait GWAS methods"
- et al 2017, "Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies"
- Hazel 1943, "The Genetic Basis for Constructing Selection Indexes"
- Rae 1951, "The Importance of Genetic Correlations in Selection"
- Hazel & Lush 1943, "The efficiency of three methods of selection"
- Lerner 1950, Population genetics and animal improvement: as illustrated by the inheritance of egg production
- Falconer 1960, pg324-329
- Conner 2012, "Quantitative genetic approaches to evolutionary constraint: how useful?"
- Beldade et al 2002, "Developmental constraints versus flexibility in morphological evolution"
- Allen et al 2008, "Differences in the selection response of serially repeated color pattern characters: standing variation, development, and evolution"
- Lee et al 2012, "Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood"
- "LD Score regression distinguishes confounding from polygenicity in genome-wide association studies", Bulik-Sullivan et al 2015 (see also Shi et al 2016); LDSC
- Loh et al 2015, "Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis"
- Majumdar et al 2017, "An efficient Bayesian meta-analysis approach for studying cross-phenotype genetic associations"
- Shi et al 2016, "Contrasting the genetic architecture of 30 complex traits from summary association data"
- Lynch 2000, "Estimating genetic correlations in natural populations"
- Golan et al 2014, "Measuring missing heritability: Inferring the contribution of common variants"
- Shi et al 2016, "Local genetic correlation gives insights into the shared genetic architecture of complex traits"
- Posthuma & Boomsma 2000, "A note on the statistical power in extended twin designs"
- DeFries et al 1987, "Genetic Stability of Cognitive Development From Childhood to Adulthood"
- Wray et al 2012, "Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes"
- pg317-318 of Falconer 1960
- Schmitt et al 2007b, "Review of twin and family studies on neuroanatomic phenotypes and typical neurodevelopment"
- Almasy et al 1997, "Bivariate quantitative trait linkage analysis: pleiotropy versus co-incident linkages"
- Heath et al 1989, "Testing structural equation models for twin data using LISREL"
- Lee et al 2016, "Facial averageness and genetic quality: testing heritability, genetic correlation with attractiveness, and the paternal age effect"
- Hagenaars et al 2016b, "Genetic Prediction of Male Pattern Baldness"
- Pirastu et al 2017, "GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk"
- Deary et al 2016, "Genetic contributions to self-reported tiredness"
- Willems et al 2017, "Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness" (Supplementary Table 13: Genetic Correlations of Grip Strength with Selected Phenotype)
- Tikkanen et al 2017, "Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank"
- Harris et al 2015, "Molecular genetic contributions to self-rated health"
- Okbay et al 2016, "Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses"
- Karvinen et al 2015, "Physical activity in adulthood: genes and mortality"
- Robinson et al 2017, "Genotype-covariate interaction effects and the heritability of adult body mass index"
- Hjelmborg et al 2008, "Genetic Influences on Growth Traits of BMI: A Longitudinal Study of Adult Twins"
- Jones et al 2016, "Genome‐Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci"
- Lane et al 2016, "Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank"
- Heath et al 1990, "Evidence for Genetic Influences on Sleep Disturbance and Sleep Pattern in Twins"
- Hammerschlag et al 2017, "Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits"
- Warrington et al 2017, "Maternal and fetal genetic contribution to gestational weight gain"
- Wade et 2010, "Body mass index and breast size in women: same or different genes?"
- Hwang et al 2016, "Sweet Taste Perception is Associated with Body Mass Index at the Phenotypic and Genotypic Level"
- Demontis et al 2017, "Discovery Of The First Genome-Wide Significant Risk Loci For ADHD" (table 5)
- Sanchez-Roige et al 2017, "Genetics of the Research Domain Criteria (RDoC): genome-wide association study of delay discounting"
- Wong et al 2017, "Genetic Overlap Of Depression With Cardiometabolic Diseases And Implications For Drug Repurposing For Comorbidities"
- MDDWG PGC 2017, "Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression"
- Afari et al 2010, "Depression and Obesity: Do Shared Genes Explain the Relationship?"
- Clarke et al 2015, "Major depressive disorder and current psychological distress moderate the effect of polygenic risk for obesity on body mass index"
- Day et al 2015, "Genetic determinants of puberty timing in men and women: shared genetic aetiology between sexes and with health-related outcomes"
- Day et al 2016, "Physical and neurobehavioral determinants of reproductive onset and success"
- Mustelin et al 2009, "Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins"
- Schnurr et al 2016, "Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology
- Vattikuti et al 2012, "Heritability and Genetic Correlations Explained by Common SNPs for Metabolic Syndrome Traits"
- Nederend et al 2016, "Heritability of heart rate recovery and vagal rebound after exercise"
- Eppinga et al 2016, "Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality"
- Joshi et al 2017, "Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity" (supplementary data 5)
- de Geus et al 2003, "Genetic correlation of exercise with heart rate and respiratory sinus arrhythmia"
- Kupper et al 2005, "A genetic analysis of ambulatory cardiorespiratory coupling"
- Snieder et al 1997, "Heritability of respiratory sinus arrhythmia: Dependency on task and respiration rate"
- Trzaskowski et al 2013, "DNA Evidence for Strong Genome-Wide Pleiotropy of Cognitive and Learning Abilities"
- Robinson et al 2017, "Genetic evidence of assortative mating in humans"
- Horikoshi et al 2016, "Genome-wide associations for birth weight and correlations with adult disease"
- De Silva et al 2017, "Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity"
- Jermendy et al 2017, "Assessing genetic and environmental influences on epicardial and abdominal adipose tissue quantities: A classical twin study"
- Barban et al 2016, "Genome-wide analysis identifies 12 loci influencing human reproductive behavior" (supplement)
- Savage et al 2017, "GWAS meta-analysis (_n_=279,930) identifies new genes and functional links to intelligence"
- Cite error: The named reference
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- Hall et al 2017, "Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank"
- Zietsch et al 2013, "Perfect genetic correlation between number of offspring and grandoffspring in an industrialized human population"
- Black 1982, "Quantitative genetics of anthropometric variation in the Solomon Islands"
- Cole et al 2017, "Human Facial Shape and Size Heritability and Genetic Correlations" (supplementary Table S4)
- "Novel genetic loci underlying human intracranial volume identified through genome-wide association", Adams et al 2016
- Trampush et al 2017, "GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium"
- Hodgson et al 2016, "Shared Genetic Factors Influence Head Motion During MRI and Body Mass Index"
- Mostafavi et al 2017, "Identifying genetic variants that affect viability in large cohorts"
- Jones et al 2017, "GWAS of self-reported mosquito bite size, itch intensity and attractiveness to mosquitoes implicates immune-related predisposition loci"
- Grotzinger et al 2017, "Genetic and Environmental Influences on Pubertal Hormones in Human Hair across Development"
- Kemp et al 2017, "Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis"
- Pennington et al 2000, "A twin MRI study of size variations in human brain"
- Posthuma et al 2000, "Multivariate genetic analysis of brain structure in an extended twin design"
- Baaré et al 2001, "Quantitative genetic modeling of variation in human brain morphology"
- Posthuma et al 2002, "The association between brain volume and intelligence is of genetic origin"
- Thompson et al 2002, "Mapping genetic influences on human brain structure"
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- Pfefferbaum et al 2004, "Morphological changes in aging brain structures are differentially affected by time-linked environmental influences despite strong genetic stability"
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- Peper et al 2007, "Genetic influences on human brain structure: a review of brain imaging studies in twins"
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- Panizzon et al 2009, "Distinct Genetic Influences on Cortical Surface Area and Cortical Thickness"
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