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Genzyme Corporation
Fully Owned Subsidiary
Industry Biotechnology
Founded Boston, Massachusetts (1981)
Headquarters Cambridge, Massachusetts, United States
Key people
Chris Viehbacher, Chairman of the Board and C.E.O.[1]
Products Cerezyme
More Complete Product List
Revenue US $4.61 billion (2007 calendar)[2]
IncreaseUS $581 million (2007 calendar)[2]
IncreaseUS $421 million (2007 calendar)[2]
Number of employees
12,000 (2010)
Parent Sanofi

Genzyme Corporation is an American biotechnology company based in Cambridge, Massachusetts. Since its acquisition in 2011, Genzyme has been a fully owned subsidiary of Sanofi. In 2010 Genzyme was the world’s third-largest biotechnology company, employing more than 11,000 people around the world. As a subsidiary of Sanofi, Genzyme has a presence in approximately 65 countries, including 17 manufacturing facilities and 9 genetic-testing laboratories, its products are sold in 90 countries. In 2007, Genzyme generated $3.8 billion in revenues with more than 25 products in the market. In 2006 and 2007 Genzyme was named one of Fortune Magazine’s “100 Best Companies to Work for”. The company donated $83 million worth of products worldwide; in 2006, it made $11 million in cash donations. In 2005, Genzyme was awarded the National Medal of Technology, the highest level of honor awarded by the president of the United States to America’s leading innovators.[3]


The company was started by Sheridan Snyder and George M. Whitesides in 1981.[4] Genzyme's scientific founder was Henry Blair who had a contract with the National Institutes of Health (NIH) to produce modified enzymes for the NIH and test it in clinical trials.[5] Blair was a technician at the New England Enzyme Center at Tufts Medical School.[5]

Genzyme's first office was an old clothing warehouse adjacent to Tufts Medical School.[5]

In 1984, Robin Berman, MD, who volunteered at the NIH, had a three-year-old son Brian, who had Gaucher's disease. He was scheduled for a spleen removal but his mother pleaded with Roscoe Brady, MD an expert in Gaucher's disease to include Brian in the clinical trial of Ceredase along with the other seven patients who were all adults.[6]

Genzyme is primarily devoted to finding drugs that would cure enzyme deficiency conditions that were essential to human survival and which usually afflict a very small percentage of the world’s population. Drugs used to treat such conditions are considered to be “orphan drugs.” In 1986, the company went public, raising $27 million.

Genzyme acquired several of Impath's laboratories and cancer-testing technologies in May 2004, after Impath sought Chapter 11 bankruptcy protection.[7]


Genzyme focuses on six areas of medicine relating to lysosomal storage diseases, renal disease, orthopedics, transplant and immune diseases, oncology, genetics and diagnostics. The first orphan-drug for Genzyme that FDA approved was Ceredase, a drug for treating Gaucher disease. Ceredase was eventually replaced by Cerezyme, which, at a cost of $200,000 per patient annually for life, currently accounts for approximately 30% of Genzyme's revenue. Other important drugs made by Genzyme are Renagel, used in treatment of dialysis patients, and Fabrazyme, used to treat patients with Fabry's disease. Other products in development are Tolevamer for Clostridium difficile colitis and Campath for Chronic lymphocytic leukemia.

Genzyme had a sub-license from Bioenvision to market clofarabine in North America. On May 29, 2007 Genzyme made a tender offer to purchase Bioenvision for $5.60 per share. On October 27, 2007, a majority of shareholders voted to approve Genzyme's acquisition.[8] In 2007, CEO, President, and Board Chairman Henri Termeer, earned a salary of $2.5 million, and non-cash compensation worth $129 million.[9]

In 2010, Genzyme launched a kidney medication for the Irish market from its Waterford base which it had set up nine years previously.[10]

Contamination incidents[edit]

The troubled Genzyme plant in Allston, Massachusetts

In June 2009, Genzyme's Allston, Massachusetts plant was shut down to correct a viral contamination (Vesivirus 2117). A similar event had occurred in 2008 at the Geel, Belgium facilities. By April 2010 it had restarted operation at diminished capacity.[11]

In November 2009, fragments of stainless steel, rubber, and fiber-like material were discovered in some of Genzyme's drugs. The FDA found these materials in Cerezyme, Genzyme's treatment for Gaucher disease, a rare genetic disorder that can lead to life-threatening organ damage. The FDA is permitting the drug to stay in the market, due to a lack of adverse events, and a critical need for the product.[12]

Supplies of Fabrazyme, Genzyme's treatment for Fabry disease, have been rationed to one-third the recommended dose prompting patients to file a petition asking for a license to produce Fabrazyme by other manufacturers to make up the deficit under the Bayh–Dole Act.[13]



Genzyme has spent more than $8.2 million on lobbying from 2007 to 2009. In 2009 alone, it had 10 different organizations with a total of 49 lobbyists working on its behalf.[14]

Takeover bid[edit]

On August 30, 2010, Sanofi announced a bid to acquire Genzyme for $18.5 billion. The deal was later rejected by the board of Genzyme. On February 16, 2011, Sanofi declared the full acquisition of Genzyme for $20.1 billion.[15]


  1. ^ Christopher A. Viehbacher. Sanofi Corporate Governance
  2. ^ a b c Yahoo!Finance. "Income Statement for Genzyme". Yahoo!. Retrieved March 16, 2007. 
  3. ^ "The National Medal of Technology Recipients 2005 Laureates". The National Medal of Technology and Innovation. United States Patent and Trademark Office. February 19, 2009. Retrieved February 26, 2009. 
  4. ^ Michael Rosenwald (August 2010). "Can Nanotechnology Save Lives?". Smithsonian Magazine. Retrieved August 16, 2012. 
  5. ^ a b c Bruce Morgan (April 12, 2012), A Flair for the Business of Medicine: Genzyme founder Henry Blair started his career working as a technician at Tufts medical school, Tufts Now, retrieved July 17, 2015 
  6. ^ Michael Margolis (nd), Awareness First Step Toward Treating Gaucher: article by TV Producer and Gaucher Patient, Mr. Michael Margolis, retrieved July 17, 2015 
  7. ^ Craig M. Douglas (May 8, 2004). "Genzyme scoops Impath for $215M: New assets will be merged into Westborough genetic testing unit". Milford Daily News. 
  8. ^ Associated Press (October 22, 2007). "Genzyme Claims Victory in Prolonged Bid for Bioenvision". International Herald Tribune (France). Retrieved November 10, 2007. 
  9. ^ Forbes (December 2007). "Henri Termeer Profile". Henri Teemer profile. Retrieved July 10, 2008. 
  10. ^ "New kidney disease medication launched". RTÉ. February 12, 2010. Retrieved February 12, 2010. 
  11. ^ Angelo DePalma (April 15, 2010). "Viral Safety Methods for Manufacturing". Genetic Engineering & Biotechnology News (GEN) 30 (8). 
  12. ^ Steel, rubber, found in some genzyme drugs. Reuters. November 13, 2009
  13. ^ "With A Life-Saving Medicine In Short Supply, Patients Want Patent Broken". August 4, 2010. 
  14. ^ Genzyme Corp. "Client Profile: Summary", Center for Responsive Politics, 2008 
  15. ^ Regan, James (February 3, 2011). "Sanofi could announce Genzyme deal next week – report". Reuters. 

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