Fabricius was born in Chemnitz in Saxony and educated at the University of Leipzig. Travelling in Italy with one of his pupils, he made an exhaustive study of the antiquities of Rome. He published the results in his Roma (1550), in which the correspondence between every discoverable relic of the old city and the references to them in ancient literature was traced in detail. In 1546 he was appointed rector of Saint Afra in Meissen.
In 1549 Fabricius edited the first short selection of Roman inscriptions specifically focusing on legal texts. This was a key moment in the history of classical epigraphy: for the first time in print a humanist explicitly demonstrated the value of such archaeological remains for the discipline of law, and implicitly accorded texts inscribed in stone as authoritative status as those recorded in manuscripts.
In his sacred poems he affected to avoid every word with the slightest savour of paganism; and he blamed the poets for their allusions to pagan divinities.
He encouraged music at his school, although he was not himself a musician. Some of his writings were set to music by composers such as Martin Agricola, Johann Walter, Mattheus Le Maistre, Antonio Scandello, Johann Reusch and Wolfgang Figulus.
Fabricius died at Meissen.
- editions of Terence (1548), Virgil (1551) and Horace (1555, apud H. Petrum)
- Roma (1550) 
- Poëmatum sacrorum libri xxv. (1560)
- Poëtarum veterum ecclesiasticorum opera Christiana (1562)
- De Re Poëtica libri septem (1565)
- Rerum Misnicarum libri septem (1569)
From: In Praise of Georgius Agricola
"Death comes to all
But great achievements raise a monument
Which shall endure until the sun grows old."
- Originum I illustrissimae stirpis Saxonicae libri septem (1597)
- Rerum Germaniae magnae et Saxoniae universae memorabilium mirabiliumque volumina duo (1609).
A life of Georg Fabricius was published in 1839 by D. C. W. Baumgarten-Crusius, who in 1845 also issued an edition of Fabricius's Epistolae ad W Meurerum et alios aequales, with a short sketch De Vita Ge. Fabricius de gente Fabriciorum; see also F. Wachter in Ersch and Gruber's Allgemeine Encyclopädie.
- "Georg Fabricius". Encyclopædia Britannica 1911. Retrieved 23 April 2013.
- Hüschen, Heinrich (2001). "Fabricius [Goldschmidt], Georg". Grove Music Online (8th ed.). Oxford University Press.
- "Quotations by Author: George Fabricius". The Quotations Page. Retrieved 23 April 2013.