George A. Bray

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George A. Bray
Born (1931-07-25) July 25, 1931 (age 87)
EducationBrown University, Harvard Medical School
Known forObesity research
Spouse(s)Yes
Children4
Awards1988 Osborne and Mendel Award from the American Institute of Nutrition, 1994 Joseph Goldberger Award from the American Medical Association
Scientific career
FieldsEndocrinology

George A. Bray (born July 25, 1931) is an American obesity researcher. As of 2016, he is a University Professor emeritus and formerly the chief of the division of clinical obesity and metabolism at Louisiana State University's Pennington Biomedical Research Center (PBRC) in Baton Rouge.[1] He is also a Boyd Professor emeritus at PBRC, and a professor of medicine emeritus at the Louisiana State University Medical Center.[2]

Early life and education[edit]

Bray was born on July 25, 1931 in Evanston, Illinois.[3] He received his A.B. from Brown University in 1953 (Summa cum Laude and valedictorian), and his M.D. from Harvard Medical School in 1957 (Magna cum Laude).[3] He subsequently interned on the Osler Service of the Johns Hopkins Hospital in Baltimore, MD, served as a Research Associate at NIH (Mentor: Robert W. Berliner, MD), was a fellow at the National Institute for Medical Research (Mill Hill: Mentor: Rosalind Pitt-Rivers, PhD) and was a fellow at the New England Medical Center, Boston, MA (Mentor Edwin (Ted) Astwood, MD, PhD).[3]

Academic career[edit]

Bray began his academic career at the Tufts-New England Medical Center, in Boston MA in 1964 and in 1970, Bray became the director of the Clinical Research Center at the Harbor–UCLA Medical Center, Torrance, CA.[3] In between his time at UCLA and his move to the University of Southern California in 1982 as Chief of Diabetes,Bray served as the first Nutrition Coordinator in the Office of the Assistant Secretary for Health in the US Dept of Health and Human Services in Washington DC. In 1989, he became the first executive director of the Pennington Biomedical Research Center, a position he continued to hold until 1999 when he returned to his research career .[3] In 1976, he founded the International Journal of Obesity with Alan Howard, and in 1982, he founded the North American Association for the Study of Obesity (since renamed The Obesity Society).[3] In 1993, he established the journal Obesity Research (now known as Obesity), and served as its editor-in-chief from then until 1997.[3] He was also the founder of the journal Endocrine Practice, serving as its editor-in-chief from 1995 to 1996.[3]

Research work[edit]

Since he received his M.D., Bray has spent nearly all his time researching obesity.[4] One of his most cited papers published while at NIH was for a method of measuring radioactivity in aqueous solutions called "Bray's Solution" (B). Phase 1 of his work was conducted while in Boston and Los Angeles and focused on clinical and basic scientific studies relating to mechanisms for development of obesity (C, D, E). After moving to the PBRC in 1989 he began Phase 2 of his research focused on clinical studies He proposed an endocrine and metabolic hypothesis for obesity (C). He also explored obesity in patients with hypothalamic injury (D) and in patients with the Prader-Willi Syndrome (E). After moving to the Pennington Center in 1989 Bray began Phase 2 of his research which focused mainly on clinical studies (F, G, H, I). He has proposed that increasing fructose consumption may be a major contributor to rising rates of obesity.[5][6] (F). He was co-investigator of the POUNDS Lost trial, the results of which were published in 2009 (G)and in 2012. The study found that strict adherence to reduced consumption of all calories is more effective for weight loss than is strict adherence to a reduced proportion of carbohydrates, fat, or protein.[7][8] This study also showed a way to use genetic information to develop personalized dietary advice. Bray was one of the 4 investigators who developed the DASH Diet (H) which is now recommended by the Dietary Guidelines and U.S. News & World Report. He was actively involved in the Diabetes Prevention Program and the Look AHEAD clinical trial. Most recently he has explored the consequences of different levels of dietary protein during periods with excess calorie intake (I).

Memberships[edit]

Bray is a member of numerous professional organizations including The Obesity Society, The Endocrine Society, the American Diabetes Association, the American Association of Clinical Endocrinologists, and the American Physiological Society.[2] He received the Goldberger Award from the American Medical Association, was elected to the Society of Scholars at Johns Hopkins University, received the Osborne and Mendel Award from the American Society for Nutrition, the McCollum Award from the American Society of Clinical Nutrition, the Mead-Johynson Award and the Tops Award, Stunkard Award and Presidential Medal from the Obesity Society.

Selected publications (References to Original Articles are cited with alphabetical listings)[edit]

A.    Bray, GA Why Obesity. Annu Rev Nutr 2015;35:1-31.

B.     Bray, G.A. A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter. Anal Biochem 1:279-285, 1960 (Not in PubMed)

C.     Bray G.A. and D.A. York.  Hypothalamic and genetic obesity in experimental animals:  An autonomic and endocrine hypothesis.  Physiol Rev 59(3):719-809, 1979.

D.    Bray, G.A. and T.F. Gallagher, Jr. Manifestations of hypothalamic obesity in man: A comprehensive investigation of eight patients and a review of the literature. Medicine 54:301-330, 1975 PMID 1152672.

E.     Bray, G.A., W.T. Dahms, R.S. Swerdloff, R.H. Fiser, R.L. Atkinson and R.E. Carrel. The Prader-Willi Syndrome: A study of 40 patients and a review of the literature. Medicine 62(2):59-80, 1983 PMID 6338343.

F.      Bray GA, Popkin BM. Calorie-sweetened beverages and fructose: what have we learned 10 years later. Pediatr Obes. 2013 Aug;8(4):242-8. doi: 10.1111/j.2047-6310.2013.00171.x. Epub 2013 Apr 29. Review.PMID 23625798.

G.    Sacks FM, G.A.Bray, V. Carey, S.R. Smith, D.H. Ryan, S. Anton, K. McManus, C.M. Champagne, L.M. Bishop, N. Laranjo, M.S. Leboff,  J.C. Rood, L.D. Levitan, F.L. Greenway,  C.M. Loria, E. Obarzanek, D.A. Williamson. Comparison of weight-loss diets with different compositions of fat, protein and carbohydrates.  N Engl J Med 360:859-873, 2009 PMID 19246357.

H.    Bray, G.A., W.M. Vollmer, F.M. Sacks, E. Obarzanek, L. Svetkey,  L.J. Appel for the DASH Collaborative Research Group.  A further subgroup analysis of the effects of the DASH diet and three dietary sodium levels on blood pressure: Results of the DASH-Sodium Trial.  Am J Cardiol 94:222-227, 2004.

I.       Bray GA, Smith SR, de Jonge L, Xie H, Rood J, Martin CK, Most M, Brock C, Mancuso S, Redman L. Effect of dietary protein content on weight gain, energy expenditure, and body composition during overeating: a randomized controlled trial. JAMA. 2012;307(1):47-55. J. George A. Bray, MD, an oral history conducted in 2014 by Michael Chappelle, The Endocrine Society, The Clark Sawin Library, Washington, DC 2014.

References[edit]

  1. ^ Consumer Reports (20 January 2014). "Tapping the power of protein". Washington Post. Retrieved 13 July 2015.
  2. ^ a b "Dr. George Bray". American Board of Obesity Medicine. Retrieved 13 July 2015.
  3. ^ a b c d e f g h "George A. Bray CV" (PDF). Retrieved 13 July 2015.
  4. ^ "What Makes Us Fat?: Calories In vs. Calories Out". Men's Journal. Retrieved 13 July 2015.
  5. ^ Schuster, Larry (29 August 2002). "Obesity expert cites fructose, soft drinks". UPI. Retrieved 13 July 2015.
  6. ^ Warner, Melanie (2 July 2006). "A Sweetener With a Bad Rap". New York Times. Retrieved 13 July 2015.
  7. ^ de Souza, RJ; Bray, GA; Carey, VJ; Hall, KD; LeBoff, MS; Loria, CM; Laranjo, NM; Sacks, FM; Smith, SR (March 2012). "Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial". The American Journal of Clinical Nutrition. 95 (3): 614–25. doi:10.3945/ajcn.111.026328. PMC 3278241. PMID 22258266.
  8. ^ Fontenot, Beth (17 February 2012). "A Calorie Is a Calorie Is a Calorie: All Diets Work if You Stick to Them". The Atlantic. Retrieved 13 July 2015.