Little's tenure was interrupted by his service in the armed forces during World War I. He served as a captain in the infantry from August 15, 1917, to August 7, 1918.
He returned and led the Redskins a 7–1 record in 1919 and a 5–2–1 record in 1920. He once again won the Ohio Athletic Conference championship in 1921 with a perfect 8–0 record. The 1921 team scored 238 points during the season and gave up only 13. In his four years as Miami's head coach, Little compiled a record of 27–3–2 including 21 games where the opponent did not score. He left Miami to become Fielding H. Yost's top assistant at the University of Michigan.
Little was the top assistant under Yost for two seasons at Michigan before being named head coach in 1924. That year, he compiled a record of 6–2. Little and the Wolverines shut out their opponents in five of the six victories. After that season, Little left to accept the head football coach and athletic director positions at the University of Wisconsin–Madison.
In his two years as the Badgers head coach, Little compiled a record of 11–3–2. His most successful year at Wisconsin was in 1925 when he led the Badgers to a 6–1–1 record and a second place finish in the Big Ten Conference. His one loss in the conference was to his former team, Michigan, by a score of 21–0. The Wolverines were led by Yost, who had returned to the head coaching position.
^Census entry for George Little and family. Ancestry.com. 1900 United States Federal Census [database on-line]. Census Place: Wolf, Lycoming, Pennsylvania; Roll: T623_1438; Page: 4A; Enumeration District: 69.
^Ancestry.com. Ohio Soldiers in WWI, 1917-1918 [database on-line]. Provo, UT, USA: Ancestry.com Operations Inc, 2005. Original data: The Official Roster of Ohio Soldiers, Sailors, and Marines in the World War, 1917-18. Columbus, OH, USA: The F.J. Heer Printing Co., 1926.
^Draft Registration Card for George Edkin Little, born May 27, 1889. Ancestry.com. U.S. World War II Draft Registration Cards, 1942 [database on-line]. National Archives and Records Administration (NARA); Washington, D.C.; State Headquarters: New Jersey.