He was a younger son of John Monoux of Stanford, Worcestershire.
On 15 June 1527 Monoux purchased land for almshouses and a school in Walthamstow. He left property worth £50 a year to pay the salaries of a schoolmaster and parish clerk, who were to pray for the souls of Monoux and his wives and to teach up to thirty children. This chantry endowment lasted until 1548 when it was suppressed in the Reformation. 
He died in February 1544 and was buried at Walthamstow. He had married twice: firstly Joan, with whom he had a son and 2 daughters; and secondly Anne, the daughter and coheiress of John Wood of Southwark, Surrey, and the widow of Robert Wattes of London. It is commonly assumed that the pronunciation of his name excludes the "x". However, a letter sent to him spells his name "Monneks," indicating that the "x" was pronounced.
- Alfred P. Beaven (1908). "Aldermen of the City of London: Bassishaw ward". The Aldermen of the City of London: Temp. Henry III - 1912. Institute of Historical Research.
- W.R.Powell (editor) (1973). "Walthamstow: Churches". A History of the County of Essex: Volume 6. Institute of Historical Research.
- "Our History". Sir George Monoux College.
- "MONOUX, George (by 1465-1544), of Bristol, Glos.; London and Walthamstow, Essex.". History of Parliament Online. Retrieved 6 September 2013.
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