Williams scored 311 points in 1920–21, which was a school record that stood for over 30 years. Regarded by Missouri basketball supporters as one of the greatest centers in program history, he led the Tigers to a two-year cumulative record of 34–2. He is still the only University of Missouri player to be named the national player of the year in men's basketball. His older brother Fred was also an All-American at Missouri.
After college, Williams played AAU basketball and won two national championships, first with Lowe & Campbell's in 1922 and then with Kansas City AC Diamonds in 1923.