Geraniol 8-hydroxylase

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Geraniol 8-hydroxylase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Geraniol 8-hydroxylase (EC, CYP76B6, G10H, CrG10H, SmG10H) is an enzyme with systematic name geraniol,NADPH:oxygen oxidoreductase (8-hydroxylating).[1][2][3] This enzyme catalyses the following chemical reaction

geraniol + NADPH + H+ + O2 (6E)-8-hydroxygeraniol + NADP+ + H2O

Geraniol 8-hydroxylase is a cytochrome P450 and therefore requires a partner cytochrome P450 reductase for functional expression.


  1. ^ Collu, G.; Unver, N.; Peltenburg-Looman, A.M.; van der Heijden, R.; Verpoorte, R.; Memelink, J. (2001). "Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis". FEBS Lett. 508 (2): 215–220. doi:10.1016/s0014-5793(01)03045-9. PMID 11718718. 
  2. ^ Wang, J.; Liu, Y.; Cai, Y.; Zhang, F.; Xia, G.; Xiang, F. (2010). "Cloning and functional analysis of geraniol 10-hydroxylase, a cytochrome P450 from Swertia mussotii Franch". Biosci. Biotechnol. Biochem. 74 (8): 1583–1590. doi:10.1271/bbb.100175. PMID 20699579. 
  3. ^ Sung, P.H.; Huang, F.C.; Do, Y.Y.; Huang, P.L. (2011). "Functional expression of geraniol 10-hydroxylase reveals its dual function in the biosynthesis of terpenoid and phenylpropanoid". J. Agric. Food Chem. 59 (9): 4637–4643. doi:10.1021/jf200259n. PMID 21504162. 

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