Geranylgeranyl pyrophosphate

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Geranylgeranyl pyrophosphate
Geranylgeranyl pyrophosphate.png
IUPAC name
6699-20-3 YesY
ChEBI CHEBI:48861 YesY
ChemSpider 394418 YesY
Jmol-3D images Image
MeSH geranylgeranyl+pyrophosphate
PubChem 447277
Molar mass 450.45 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway used by organisms in the biosynthesis of terpenes and terpenoids.[1] In plants it is also the precursor to carotenoids, gibberellins, tocopherols, and chlorophylls.

It is also a precursor to geranylgeranylated proteins, which is its primary use in human cells. [2]

In Drosophila, geranylgeranyl pyrophosphate is synthesised by HMG-CoA encoded by the Columbus gene. Geranylgeranyl pyrophosphate is utilised as a chemoattractant for migrating germ cells that have traversed the midgut epithelia. The attractant signal is produced at the gonadal precursors, directing the germ cells to these sites, where they will differentiate into ova (eggs) and spermatozoa (sperm).

Related compounds[edit]


  1. ^ Cholesterol Synthesis, Rensselaer Polytechnic Institute]
  2. ^ Wiemer, AJ; Wiemer, DF; Hohl, RJ (December 2011). "Geranylgeranyl diphosphate synthase: an emerging therapeutic target.". Clinical pharmacology and therapeutics 90 (6): 804–12. doi:10.1038/clpt.2011.215. PMID 22048229.