It is rumored that the song and the following music industry blacklisting of 50 Cent by Kenneth "Supreme" McGriff and his associates, led to the murder of Run DMC's Jam Master Jay. It is thought by some that Jay ignored the blacklisting by taking the young 50 Cent under his wing and introducing him to the music industry. According to an affidavit by IRS agent Francis Mace, law enforcement officials believed that the shooting of 50 Cent in 2000 was in retaliation for the lyrics of the song which detailed the history of Supreme Team, McGriff's gang.
Ghetto Qur'an served as a basis for 50 Cent's rivals (mainly Ja Rule, Irv Gotti and the Murder Inc. music group, whom he was feuding with at the time) labeling him a snitch. 50 Cent mentioned in an AllHipHop.com interview that everybody mentioned in the song appreciated it and McGriff even told him that he loved the song. He also talked about how Nas' record "Get Down" from the album God's Son similarly mentions names, but few people consider anything wrong with it.