Giacomo Pylarini (Jacob) (1659–1718) was a Venetian physician and consul for the republic of Venice in Smyrna. In 1716 he became the first person to have an account of the practice of inoculation published by the Royal Society. 
He studied law and then physic at Padua before receiving his degree of MD. He traveled to different parts of Asia and Africa and practised both at Smyrna and Constantinople. In Moscow he was appointed physician to the Russian Tsar Peter the Great.
He returned to Smyrna for the second time and resided there as the Venetian Consul as well as practising physician.
- The Clockwork Universe 1583 ce–1819 ce ISBN 978-3-540-68831-0 (Print) 978-3-540-68832-7 (Online), Springer Berlin Heidelberg
- Nova et tuta variolas excitandi per transplantationem methodus, nuper inventa & in usum tracta.
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