The biggest achievements in club history are five German Championships (1965, 1967, 1968, 1975, 1978). Besides that, the 46ers have won the German Cup three times (1969, 1973, 1979). The most recent achievements were an appearance in the BBL semifinals in 2005, when the team lost the series 1-3, to the eventual champion GHP Bamberg, and the third place in the BBL Cup in 2006.
In the 2012–13 season, the 46ers relegated from the Bundesliga for the first time. In the 2014–15 season, they were crowned the ProA champions and promoted back to the highest tier.
They are known in the USA, for having been the team for which professional wrestlerKevin Nash (also known as Diesel) finished his professional basketball career, due to a knee injury.