Gilean McVean

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Gil McVean
Professor Gilean McVean FMedSci FRS.jpg
Gil McVean at the Royal Society admissions day in London in 2016
Born Gilean Alistair Tristram McVean
February 1973 (age 44)[1]
Alma mater
Scientific career
Thesis Adaptation and conflict : the differences between the sexes in mammalian genome evolution (1998)
Doctoral advisor Laurence Hurst[3][4][5]
Other academic advisors
Doctoral students

Gilean Alistair Tristram McVean (born 1973)[1] FRS[11] FMedSci is a professor of statistical genetics at the University of Oxford,[12] director of the Big Data Institute,[13] fellow of Linacre College, Oxford and co-founder and director of Genomics plc.[1][14] He also co-chaired the 1000 Genomes Project analysis group.[15][16]


Gilean McVean speaking at the 2010 GEM meeting at the Wellcome Trust Sanger Institute (WTSI), Hinxton.

From [17][18] McVean completed his PhD in the Department of Genetics, at the University of Cambridge supervised by Laurence Hurst[19][20] in 1998.[4][21]

Career and research[edit]

Following his PhD, McVean completed postdoctoral research at the University of Edinburgh from 1997 to 2000 supervised by Brian Charlesworth and Deborah Charlesworth.[22][23] From 2000-2004 he was a Royal Society University Research Fellow, in the Department of Statistics at Oxford, where he has also been a University lecturer in Mathematical Genetics since 2004 (reappointed in 2009 until retirement age).[24] In October 2006 he was appointed professor of statistical genetics at the University of Oxford.[25]

His research[26] focuses on population genetics, statistics[27] and evolutionary biology including the International HapMap Project,[28][29] recombination rates in the human genome[30] and the 1000 Genomes Project.[31][32] He developed a statistical method to look at recombination rate which helped to identify PRDM9 as a hotspot positioning gene.[33]

In 2014 with Peter Donnelly he co-founded Genomics plc, a genomics analysis company, as a corporate spin-off of the University of Oxford.[1]

He was appointed as acting director of the Big Data Institute at the University of Oxford.[when?][13]

Honours and awards[edit]

In 2006 he was awarded a Philip Leverhulme Prize.[34][35]

In 2010 McVean was awarded the Francis Crick Medal and delivered that years lecture entitled "Our genomes, our history".[36]

In 2012 McVean was awarded the Weldon Memorial Prize.[37]

In 2013 McVean presented at TEDxWarwick with a talk entitled A Thousand Genomes a Thousand Stories.[38]

In May 2014 McVean was elected as a member of the European Molecular Biology Organisation.[39]

McVean was elected Fellow of the Royal Society (FRS) in 2016[11] and a Fellow of the Academy of Medical Sciences (FMedSci).[40][41]


  1. ^ a b c d Anon (2016). "Gilean MCVEAN Date of birth: February 1973". London: Companies House. Archived from the original on 2016-08-12. 
  2. ^ Crick Lectures
  3. ^ Hurst, L.; McVean, G. (1996). "A difficult phase for introns-early. Molecular evolution". Current Biology. 6 (5): 533–536. PMID 8805261. doi:10.1016/S0960-9822(02)00535-3. 
  4. ^ a b McVean, Gilean Alistair Tristram (1998). Adaptation and conflict : the differences between the sexes in mammalian genome evolution (PhD thesis). University of Cambridge. OCLC 894602716. 
  5. ^ "Students and post-docs past and present in the Hurst laboratory". University of Bath. Archived from the original on 2015-05-15. 
  6. ^ Matieson, Iain (2013). Genes in space: Selection, association and variation in spatially structured populations. (PDF) (DPhil thesis). University of Oxford.  open access publication – free to read
  7. ^ Auton, Adam (2007). The Estimation of Recombination Rates from Population Genetic Data. (PDF) (DPhil thesis). University of Oxford.  open access publication – free to read
  8. ^ Cardin, Niall (2007). Approximating the Coalescent with Recombination. (PDF) (DPhil thesis). University of Oxford.  open access publication – free to read
  9. ^ Moutsianas, Loukas (2011). Imputation aided analysis of the association between autoimmune diseases and the MHC (DPhil thesis). University of Oxford. OCLC 820778016.  open access publication – free to read
  10. ^ McVean, Gil (2016). "McVean Group". Oxford: University of Oxford. Archived from the original on 2016-03-04. 
  11. ^ a b Anon (2016). "Gilean McVean". London: Royal Society. Archived from the original on 2016-04-29.  One or more of the preceding sentences incorporates text from the website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived September 25, 2015)

  12. ^ McVean Group at the University of Oxford
  13. ^ a b "Gil McVean — Oxford Big Data Institute". Retrieved 2016-07-12. 
  14. ^ "Prof. Gil McVean - GENOMICS plc". Retrieved 2016-07-12. 
  15. ^ "Oct 10: 1000 Genomes project - Wellcome Trust Centre for Human Genetics". Retrieved 2016-07-12. 
  16. ^ Gilean McVean publications from Europe PubMed Central
  17. ^ "Gil McVean | LinkedIn". Retrieved 2016-07-12. 
  18. ^ Gil McVean's Entry at ORCID
  19. ^ McVean, G.T.; Hurst, L.D. (1997). "Evidence for a selectively favourable reduction in the mutation rate of the X chromosome". Nature. 386 (6623): 388–392. PMID 9121553. doi:10.1038/386388a0. 
  20. ^ Hurst, L.D.; McVean, G.T. (1996). "... And scandalous symbionts". Nature. 381 (6584): 650–651. PMID 8649507. doi:10.1038/381650a0. 
  21. ^ Gilean McVean Oxford University
  22. ^ Charlesworth, D.; Charlesworth, B.; McVean, G. (2001). "Genome sequences and evolutionary biology, a two-way interaction". Trends in Ecology & Evolution. 16 (5): 235–242. PMID 11301152. doi:10.1016/S0169-5347(01)02126-7. 
  23. ^ "Oxford University Statistics | Professor Gilean McVean". Retrieved 2016-07-12. 
  24. ^ "Oxford University Gazette, 14 May 2009: Examinations and Boards". Retrieved 2016-07-12. 
  25. ^ "Oxford University Gazette". Archived from the original on 2 October 2013. Retrieved 12 July 2016. 
  26. ^ Gilean McVean in Google Scholar
  27. ^ Reshef, D. N.; Reshef, Y. A.; Finucane, H. K.; Grossman, S. R.; McVean, G.; Turnbaugh, P. J.; Lander, E. S.; Mitzenmacher, M.; Sabeti, P. C. (2011). "Detecting Novel Associations in Large Data Sets". Science. 334 (6062): 1518–1524. PMC 3325791Freely accessible. PMID 22174245. doi:10.1126/science.1205438. 
  28. ^ Frazer, K. A.; Frazer, D. G.; Ballinger, D. R.; Cox, D. A.; Hinds, L. L.; Stuve, R. A.; Gibbs, J. W.; Belmont, A.; Boudreau, P.; Hardenbol, S. M.; Leal, S.; Pasternak, D. A.; Wheeler, T. D.; Willis, F.; Yu, H.; Yang, C.; Zeng, Y.; Gao, H.; Hu, W.; Hu, C.; Li, W.; Lin, S.; Liu, H.; Pan, X.; Tang, J.; Wang, W.; Wang, J.; Yu, B.; Zhang, Q.; Zhang, H. (2007). "A second generation human haplotype map of over 3.1 million SNPs". Nature. 449 (7164): 851–861. PMC 2689609Freely accessible. PMID 17943122. doi:10.1038/nature06258. 
  29. ^ Sabeti, Pardis C.; Varilly, Patrick; Fry, Ben; Lohmueller, Jason; Hostetter, Elizabeth; Cotsapas, Chris; Xie, Xiaohui; Byrne, Elizabeth H.; McCarroll, Steven A.; Gaudet, Rachelle; Schaffner, Stephen F.; Lander, Eric S.; The International HapMap Consortium; Frazer, Kelly A.; Ballinger, Dennis G.; Cox, David R.; Hinds, David A.; Stuve, Laura L.; Gibbs, Richard A.; Belmont, John W.; Boudreau, Andrew; Hardenbol, Paul; Leal, Suzanne M.; Pasternak, Shiran; Wheeler, David A.; Willis, Thomas D.; Yu, Fuli; Yang, Huanming; Zeng, Changqing Zeng; Gao, Yang (2007). "Genome-wide detection and characterization of positive selection in human populations". Nature. 449 (7164): 913–918. PMC 2687721Freely accessible. PMID 17943131. doi:10.1038/nature06250. 
  30. ^ McVean, G. A. T.; Myers, S.; Hunt, S.; Deloukas, P.; Bentley, D.; Donnelly, P. (2004). "The Fine-Scale Structure of Recombination Rate Variation in the Human Genome". Science. 304 (5670): 581–584. PMID 15105499. doi:10.1126/science.1092500. 
  31. ^ Danecek, P.; Auton, A.; Abecasis, G.; Albers, C. A.; Banks, E.; Depristo, M. A.; Handsaker, R.; Lunter, G.; Marth, G.; Sherry, S. T.; McVean, G.; Durbin, R.; 1000 Genomes Project Analysis Group (2011). "The Variant Call Format and VCFtools". Bioinformatics. 27 (15): 2156–2158. PMC 3137218Freely accessible. PMID 21653522. doi:10.1093/bioinformatics/btr330. 
  32. ^ Hernandez, R. D.; Kelley, J. L.; Elyashiv, E.; Melton, S. C.; Auton, A.; McVean, G.; 1000 Genomes Project; Sella, G.; Przeworski, M. (2011). "Classic Selective Sweeps Were Rare in Recent Human Evolution". Science. 331 (6019): 920–924. PMC 3669691Freely accessible. PMID 21330547. doi:10.1126/science.1198878. 
  33. ^ "Gilean McVean". Retrieved 2016-07-12. 
  34. ^ "AWARDS MADE IN 2006" (PDF). The Leverhulme Trust. 2006. Retrieved 2016-07-12. 
  35. ^ "Philip Leverhulme Prizes 2006" (PDF). The Leverhulme Trust. 2006. Retrieved 2016-07-12. 
  36. ^ The Royal Society (2013-12-10), Our genomes, our history, retrieved 2016-07-12 
  37. ^ "Professor Gil McVean awarded the Weldon Memorial Prize 2012 - Wellcome Trust Centre for Human Genetics". Retrieved 2016-07-12. 
  38. ^ TEDx Talks (2013-03-29), A Thousand Genomes a Thousand Stories: Gilean McVean at TEDxWarwick 2013, retrieved 2016-07-12 
  39. ^ "EMBO enlarges its membership for 50th anniversary". Retrieved 2016-07-12. 
  40. ^ "New Fellows | Academy of Medical Sciences". Retrieved 2016-07-12. 
  41. ^ "Professor Gil McVean elected a Fellow of the Royal Society - GENOMICS plc". Retrieved 2016-07-12.