The song's music video, directed by Dr. Dre, Calvin Caday and Anita Sisaath, also producers of 2Pac's "Dear Mama", features teenager Snoop throwing a wild house party after his parents leave the house. Ricky Harris plays Snoop's father, and Dr. Dre, Warren G, Nate Dogg and Daz Dillinger make cameo appearances. Six-year-old rapper Lil Bow Wow plays Snoop's little brother who is jumping on the couch in the intro. "I was in the 'Gin and Juice' video," comedian Eddie Griffin recalled. "I pop out of this little Volkswagen full of weed smoke with my hair standing on end."
The small-budget idea was later re-purposed in videos such as J-Kwon's "Tipsy" and Oowee's "Why Cry", which features Snoop and is a shot-by-shot remake of the "Gin and Juice" video. The music video was parodied in the video for "DPK", where Snoop, carried on the front of a bicycle, gets hit by a car driven by B.G. Knocc Out and Dresta, two of Eazy-E's protégés with whom Snoop Dogg and Dr. Dre had feuds at the time.
Chamillionaire used the text phrase "With so much drama in the LBC. It's kinda hard being Snoop D O double-G" and changed it to "With so much drama in the industry. Hip-hop police are listening" for his chorus in the song Hip Hop Police.
Makiza sampled the song in song "La Rosa de los Vientos"
The Notorious B.I.G. used a modified version of the instrumental in his lesser known song "Road to Riches"
Demi Lovato sampled it in her song "Cool for the Summer" from her 2015 album Confident, using "with my mind on my money and my money on my mind" twisting it into "with my mind on your body and your body on my mind".