The song's music video, directed by Dr. Dre, Calvin Caday and Anita Sisaath, also producers of 2Pac's "Dear Mama", features a simple concept: teenager Snoop throws a wild house party after his parents leave the house. Ricky Harris plays Snoop's father, and Dr. Dre, Warren G, Nate Dogg and Daz Dillinger make cameo appearances. Six-year-old rapper Lil Bow Wow plays Snoop's little brother who is jumping on the couch in the intro.
The small-budget idea was later re-purposed in videos such as J-Kwon's "Tipsy" and Oowee's "Why Cry", which features Snoop and is a shot-by-shot remake of the "Gin and Juice" video. The music video was parodied in the video for "DPK", where Snoop, carried on the front of a bicycle, gets hit by a car driven by B.G. Knocc Out and Dresta, two of Eazy-E's protégés with whom Snoop Dogg and Dr. Dre had feuds at the time.
Chamillionaire used the text phrase "With so much drama in the LBC. It's kinda hard being Snoop D O double-G" and changed it to "With so much drama in the industry. Hip-hop police are listening" for his chorus in the song Hip Hop Police.
Makiza sampled the song in song "La Rosa de los Vientos"
The Notorious B.I.G. used a modified version of the instrumental in his lesser known song "Road to Riches"
Oowee sampled elements for his song titled "Why Cry" which also featured Snoop Dogg Himself