He has published a series of books on philosophy of medicine and biology. Together with Thomas Sebeok and Thure von Uexküll, he has developed a semiotic approach in biology (biosemiotics) in his works of the 1970s and 1980s.
For his honour, there exists "Giorgio Prodi" Centre of Cancer Research in the University of Bologna.
His brother is Romano Prodi.
- Cimatti, Felice 2000. The circular semiosis of Giorgio Prodi. Sign Systems Studies 28: 351-379.
- Prodi, Giorgio 1988. Teoria e metodo in biologia e medicina. Bologna: Editrice CLUEB.
- Sebeok, Thomas 1998. The Estonian connection. Sign Systems Studies 26: 20-41.
- Prodi, Giorgio 1988. Material bases of signification. Semiotica 69: 191-241.