A native of Tondo, the poorest district of Manila, and one of the most densely populated areas in the world, Giovannie Anne Cabangis-Espiritu became a performer at a young age and, by her early twenties, starred in a number of Philippine-made internationally produced films and TV programs. She was cast as the female lead in the movie American Yearbook and earned plaudits for her performance, notably in view of the fact that the producers originated the part with a Caucasian actress in mind.
Upon arriving in the United States, Giovannie Pico matriculated at Harvard Law School, intending to study advanced negotiation skills, but the pressures of her show business career constrained to keep her in Hollywood. In addition to her role as ER's Ludlow, she has also appeared on 2007 episodes of Bones (as Rose Allipo) and Gilmore Girls (as Karen). While playing a starring role in the 2006 independently-produced 40-minute TV movie Kambal: The Twins of Prophecy, she received a credit as the film's executive producer. As an activist in the area of domestic violence awareness and prevention, she has donated her time by directing benefit productions of Eve Ensler's play The Vagina Monologues at the Herbst Theater in San Francisco.
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