"Girls, Girls, Girls" is the second single from rapper Jay-Z's album The Blueprint. It is a playful description of the artist's promiscuous lifestyle. The song contains a sample of "There's Nothing In This World That Can Stop Me From Loving You" by Tom Brock. The chorus features a lyrical interpolation of "High Power Rap" by Crash Crew. The song has additional vocals sung by Q-Tip, Slick Rick and Biz Markie, but they are not credited as featured guests on the back artwork; they are, however, credited in the album's liner notes.
A remix of the song produced by Kanye West can be found as a hidden track on The Blueprint after the songs "Blueprint (Momma Loves Me)" and the other hidden song "Lyrical Exercise". The remix is composed of new verses by Jay-Z, a new instrumental sampling "Trying Girls Out" by The Persuaders and uncredited vocals from Michael Jackson and Chante Moore. Just Blaze originally produced the song for Ghostface Killah.