Gitoformate

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Gitoformate
Gitoformate skeletal.svg
Clinical data
Trade names Dynocard
ATC code C01AA09 (WHO)
Identifiers
Synonyms Gitoxin 3',3'',3''',4''',16-pentaformate
CAS Number 10176-39-3 YesY
PubChem (CID) 65598
ChemSpider 16736524 N
UNII B69U29O7J9 YesY
KEGG D07147 N
ChEMBL CHEMBL2103959 N
Chemical and physical data
Formula C46H64O19
Molar mass 920.989 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Gitoformate (INN, or pentaformylgitoxin, trade name Dynocard) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat).[1] Produced by Madaus, it is not available in the US, and does not seem to be available in Europe either.

Chemistry[edit]

Gitoxigenin, the aglycon

Gitoformate is a derivative of the glycoside gitoxin, with five of the six free hydroxyl groups formylated, one on the aglycon and four on the sugar.[2][3] Gitoxin, a cardiac glycoside from the woolly foxglove (Digitalis lanata), has an aglycon of the cardenolide type named gitoxigenin, which is also the aglycon of lanatoside B, another Digitalis lanata glycoside.[4]

References[edit]

  1. ^ Rietbrock, N.; Woodcock, B. G.; Hrazdil, U. (1984). "Gitoformate and digitoxin as alternatives to kidney-dependent glycosides in the therapy of cardiac insufficiency". Arzneimittel-Forschung. 34 (8): 915–917. PMID 6541927. 
  2. ^ Dei Cas, L.; Affatato, A.; Buia, E.; Casciarri, G.; Faggiano, P.; Giunti, G.; Metra, M.; Pelagatti, T.; Quinzanini, M. (1984). "Plasma levels of gitoxin (by RIA and rubidium-86 uptake) and systolic time after treatment with a single dose of gitoformate". Cardiologia (Rome, Italy). 29 (5–6): 291–300. PMID 6542412. 
  3. ^ CID 91540 from PubChem
  4. ^ William O. Foye,Thomas L. Lemke, David A. Williams. Foye's principles of medicinal chemistry. p. 699. ISBN 978-0-7817-6879-5.